ABSTRACT

　　　　We report two cases of euthyroid Graves' disease in women who had ophthalmopathy without previous history of hyperthyroidism. Enlargement of extraocular muscles was observed by magnetic resonance imaging (MRI). The patients had no thyroid enlargement and their serum concentrations of free T4, free T3, and TSH were normal. The sera were negative for anti-thyroid microsomal and thyroglobulin antibodies, and anti-TSH receptor antibodies measured by radio-receptor assay. T3 suppression test results were normal. Only thyroid-stimulating antibody (TSAb) measured by sensitive bioassay were positive. These findings indicate that sensitive TSAb is the most useful laboratory test in the diagnosis of euthyroid Graves' disease.

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