INTRODUCTION

　　　　 Graves' thyrotoxicosis is caused by thyroid-stimulating antibody (TSAb), and is often associated with ophthalmopathy consisting of a combination of symptoms and signs such as proptosis, lid retraction, extraocular muscle dysfunction, diplopia, eyelid edema, and optic neuropathy. However, the cause of the ophthalmopathy is still unknown. Some patients with Graves' ophthalmopathy never develop hyperthyroidism and some even have associated hypothyroidism [1, 2] , These types of the disease are termed euthyroid Graves' disease [3, 4] and hypothyroid Graves' disease, respectively. These patients often have small goiter and/or positive anti-thyroid antibodies indicating autoimmune thyroid abnormality [3, 4] . In this report, we describe two patients with non-goitrous euthyroid Graves' disease in whom laboratory data, such as TSH binding inhibitor immunoglobulins (TBII), anti-microsome antibodies (McAb), anti-thyroglobulin antibodies (TgAb), and T3-suppression test, were all normal except positive thyroid-stimulating antibody (TSAb).

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