発表論文一覧

（欧文のみ）


(2024年）

  1. Mori, S., Arakawa, Y., Hasegawa, M., Kato, S., Hashimoto, H., Yoshioka, S., Ueda, H., Osaka Twin Research Group, Watanabe, M. :Genetic and epigenetic factors affecting carotid intima-media thickness in monozygotic twins. Gene 936(5), 149093, 2025. doi: 10.1016/j.gene.2024.149093
  2. Takenaka, Y., Osaka Twin Research Group, Watanabe, M.: Development of Index to Measure the Strength of Environmental Factors on DNA Methylation in Identical Twins. Epigenomes 8(4), 44, 2024. doi: 10.3390/epigenomes8040044
  3. Yamamoto, K.,Lee, Y., Masuda, T.,Ozono, K., Iwatani, Y., Watanabe, M., Okada, Y., Sakai, N.: Functional landscape of genome-wide postzygotic somatic mutations between monozygotic twins. DNA Res,31(5), dsae028, 2024. doi: 10.1093/dnares/dsae028
  4. Ohtani, H., Inoue, N. Iwatani, Y., Takeno, Y., Arakawa, Y., Hidaka, Y., Watanabe, M.: Effect of DNA methylation at the CTLA4 gene on the clinical status of autoimmune thyroid diseases. Clin Immunol , 267, 110338, 2024. doi: 10.1016/j.clim.2024.110338
  5. Nishihara, S., Koseki, M., Tanaka, K., Omatsu, T., Saga, A., Sawabe, H., Inui, H., Okada, T., Ohama, T., Okuzaki, D., Kamada, Y., Ono, M., Nishida, M., Watanabe, M., Sakata, Y.：Tofogliflozin attenuates renal lipid deposition and inflammation via PPARalpha upregulation mediated by miR-21a impairment in diet-induced steatohepatitic mice. Endocrine J 2024 doi: 10.1507/endocrj.EJ24-0189
  6. Kinoshita, R., Inoue, N., watani, Y., Noguchi, Y., Hidaka, Y., Watanabe, M.: Methylation levels of the IL10 gene in peripheral blood are related to the intractability of Graves' disease. Clin Immunol 263:110196, 2024. doi: 10.1016/j.clim.2024.110196.
  7. Nishihara, S., Koseki, M., Tanaka, K., Omatsu, T., Sawabe, H., Inui, H., Saga, A., Okada, T., Higo, T., Ohama, T., Nishida, M., Sakata, Y., Watanabe, M., Osaka Twin Research Group: Twin Study: the factors affecting serum LDL-C and HDL-C and RNA-seq analysis in mononuclear cells in monozygotic twins. J Atheroscler Thromb, 2024 doi: 10.5551/jat.64882.
  8. Yoshioka, S., Arakawa, Y., Hasegawa, M., Kato, S., Hashimoto, H., Mori, S., Ueda, H., Osaka Twin Research Group, Watanabe, M. : Twin study: Genotype-dependent epigenetic factors affecting FT4 levels in the normal range. Epigenomics, 16(3), 147-158, 2024. doi: 10.2217/epi-2023-0372.
  9. Arakawa, Y., Tano, Y., Fujii, M., Imai, Y., Norimatsu, Y., Yasukawa, M., Watanabe, M., Yamada, T. : H3K9 demethylase plant homeodomain finger protein 2 regulates interleukin 4 production in CD4+ T cells,Cytokine, 175, 156506, 2024. doi: 10.1016/j.cyto.2024.156506.
  10. Taniguchi, J., Masuda, T., Iwatani, Y., Yamamoto, K., Osaka Twin Research Group, Sakai, N., Okada, Y., Watanabe, M.: Rigorous Evaluation of Genetic and Epigenetic effects on Clinical Laboratory Measurements using Japanese Monozygotic Twins. Clin Genet 105, 159–172, 2024. doi: 10.1111/cge.14443

(2023年）

  1. Katoh, H., Asai, H., Takemoto, K., Tomizawa, R., Honda, C., Watanabe, M., Osaka Twin Research Group, Honda, T.: Cap Analysis of Gene Expression clarifies transcriptomic divergence within and between twins. Twin Res Hum Genet, 26(4-5), 269-276, 2023. doi: 10.1017/thg.2023.42
  2. Ozaki, H., Inoue, N., Iwatani, Y., Watanabe, A., Yamamoto, M., Kitahara, N., Tanikawa, S., ,Noguchi, Y., Hidaka, Y., Watanabe, M.: Association of B7H3 and B7H4 gene polymorphisms and protein expression with the development and prognosis of autoimmune thyroid diseases. Clinical Endoclinology 99, 103–112, 2023. doi: 10.1111/cen.14923
  3. Asuka, T., Kamada, Y., Morishita, K., Fukuoka, T., Takamatsu, S., Kondo, J., Watanabe, M., Sakai, N., Hayakawa, K., Miyoshi, E., Osaka Twin Research Group: Twin research shows glycan changes are more susceptible to environmental factors than their carrier glycoproteins. Glycoconjugate J 40(2), 191-198. doi: 10.1007/s10719-023-10099-7
  4. Hasegawa, M., Taniguchi, J. Ueda, H., Watanabe, M.: Twin study: Genetic and epigenetic factors affecting circulating adiponectin levels. J Clin Endocrinol Metab 108(1), 144-154, 2023. doi: 10.1210/clinem/dgac532
  5. Haga, E., Inoue, N.,Iwatani, Y., Arakawa, Y.,Morita, E., Hashimoto, H.,Noguchi, Y.,Hidaka, Y., Watanabe. M.: Intraindividual Variation in Histone Acetylation and Its Impact on Autoimmune Thyroid Diseases. Endocrine J, 70(12), 1169-1174, 2023, doi:10.1507/endocrj.EJ23-0204

(2022年）

  1. Tabata, T., Masumura, Y., Higo, S., Kunimatsu, S., Kameda, S., Inoue, H., Okuno, S., Ogawa, S., Takashima. S., Watanabe, M., Miyagawa, S., Hikoso, S., Sakata, Y.: Multiplexed Measurement of Cell Type-specific Calcium Kinetics using High-content Image Analysis Combined with Targeted Gene Disruption. Biochem Biophys Res Com 637(31), 40-49, 2022. doi: 10.1016/j.bbrc.2022.10.088
  2. Silventoinen, K.,Piirtola ,M., Jelenkovic, A., Sund, R., Tarnoki, A.D., Tarnoki, D.L., Medda, E., Nisticò, L., Toccaceli, V., Honda, C., Inui, F., Tomizawa, R., Watanabe, M., Sakai, S., Gatz, M., Butler, D.A., Lee. J., Lee, S.J., Sung, J., Franz, C.E., Kremen, W.S., Lyons, M.J., Derom, C.A., Vlietinck, R.F., Loos, R.J.F., Tynelius, P., Rasmussen, F., Martin, N.G., Medland, S.E., Montgomery, G.W., Brandt, I., Nilsen, T.S., Harris, J.R., Tyler, J., Hopper, J.L., Magnusson, P.K.E., Pedersen, N.L., Aslan, A.K.D., Ordoñana, J.R., Sánchez-Romera, J.F., Colodro-Conde, L., Rebato, E., Zhang, D., Pang, Z., Tan, O., Silberg, J.L., Maes, H.H., Boomsma, D.I., Sørensen, T.I.A., Korhonen, T., Kaprio, J.: Smoking remains associated with education after controlling for social background and genetic factors in a study of 18 twin cohorts. Scientific Reports 12(1), 13148, 2022. doi: 10.1038/s41598-022-17536-x
  3. Kimura, T., Sakai, M., Gojo, N., Watanabe, M., Uzawa, N., Sakai, T.: The HIF-1alpha pathway plays a critical role in salivary gland development in ex vivo organ cultures. FEBS OpenBio, 12(2):460-469, 2022. doi:10.1002/2211-5463.13351
  4. Kimura, T., Sakai, M., Gojo, N., Watanabe, M., Uzawa, N., Sakai, T.: IF-1α regulates mTOR signaling pathway during salivary gland development. Biochem Biophys Res Com, 631, 130-137, 2022. doi: 10.1016/j.bbrc.2022.09.078

(2021年）

  1. Homma, H., Watanabe, M., Inoue, N., Isono, M., Hidaka, Y., Iwatani, Y.: Polymorphisms in vitamin A-related genes and their functions in autoimmune thyroid disease. Thyroid 31(11), 1749-1756, 2021. doi: 10.1089/thy.2021.0312
  2. Kawabata, M., Inoue, N., Watanabe, M., Kobayashi, A., Hidaka, Y., Miyauchi, A., Iwatani, Y.: PD-1 Gene Polymorphisms and thyroid expression of PD-1 ligands differ between Graves' and Hashimoto's diseases. Autoimmunity 54(7), 450-459, 2021. doi: 10.1080/08916934.2021.1946796.
  3. Suetake, I., Nakazawa, S., Sato, K., Mutoh, R., Mishima, Y., Kawakam, T., Takei, T., Watanabe, M., Sakai, N., Fujiwara, T., Takui, T., Miyata, M., Shinohara, A., Hojo, H., Arata. T.: Structural dynamics of the chromo-shadow domain and chromodomain of HP1 bound to histone H3K9 methylated peptide, as measured by site-directed spin-labeling EPR spectroscopy. Biochem Biophys Res Commun 567, 42-48, 2021. doi: 10.1016/j.bbrc.2021.06.010
  4. Matsumoto, N., Park, J., Tomizawa, R., Kawashima, H.,, Hosomi, K.,, Mizuguchi, K., Honda, C., Ozaki, R., Iwatani, Y., Watanab, M., Kunisawa, J.: Relationship between nutrient intake and human gut microbiota in monozygotic twins. Medicine, 57 (3), 275-287, 2021. doi: 10.3390/medicina57030275
(2020年）
  1. Silventoinen, K., Jelenkovic, A., Sund, J., Latvala, A., Honda, C., Inui, F., Tomizawa, R., Watanabe, M., Sakai, N., Rebato, E., Busjahn, A., Tyler, J., Hopper, J.L., Ordoñana, J.R., Sánchez-Romera, J.F., Colodro-Conde, L., Calais-Ferreira, L., Oliveira, V.C., Ferreira, P.H., Medda, E., Nisticò, L., Toccaceli, V., Derom, C.A., Vlietinck, R.F., Loos, R.JF., Siribaddana, S.H., Hotopf, M., Sumathipala, A., Rijsdijk, F., Duncan, G.E., Buchwald, D., Tynelius, P., Rasmussen, F., Tan, Q., Zhang, D., Pang, Z., Magnusson, P.KE., Pedersen, N.L., Aslan, A.K.D., Hwang, A.E., Mack, T.M., Krueger, R.F., McGue, M., Pahlen, S., Brandt, I., Nilsen, T.S., Harris, J.R., Martin, N.G., Medland, S.E., Montgomery, G.W., Willemsen, G., Bartels,., van Beijsterveldt, C.EM., Franz, C.E., Kremen, W.S., Lyons, M.J., Silberg, J.L., Maes, H.H., Kandler, C., Nelson, T.L., Whitfield, K.E., Corley, R.P., Huibregtse, B.M., Gatz, M., Butler, D.A., Tarnoki, A.D., Tarnoki, D.L., Park, H.A., Lee, J., Lee, S.J., Sung, J., Yokoyama, Y., Sørensen, T.IA., Boomsma, D.I., Kaprio, J.: Genetic and environmental variation in educational attainment: an individual-based analysis of 28 twin cohorts. Scirntific Reports 10(1) 12681, 2020. doi: 10.1038/s41598-020-69526-6
  2. Matsumoto, D.,Inui, F., Honda, C., Tomizawa, R., Watanabe, M., Silventoinen, K., Sakai, N.: Heritability and Environmental Correlation of Phase Angle with Anthropometric Measurements: A Twin Study. International Journal of Environmental Research and Public Health 17(21) 7810-7810, 2020. doi: 10.3390/ijerph17217810
  3. Hayashida, M., Maekawa, F., Chagi, Y., Iioka, F., Kobashi, Y., Watanabe, M., Ohno, H.: Combination of multicolor flow cytometry for circulating lymphoma cells and tests for the RHOAG17Vand IDH2R172 hot-spot mutations in plasma cell-free DNA as liquid biopsy for the diagnosis of angioimmunoblastic T-cell lymphoma. Leukemia & Lymphoma 61(10) 2389-2398, 2020. doi: 10.1080/10428194.2020.1768382.
  4. Okamoto, M., Watanabe, M., Inoue, N., Ogawa, K., Hidaka, Y., Iwatani, Y.: Gene polymorphisms of VEGF and VEGFR2 are associated with the severity of Hashimoto's disease and the intractability of Graves' disease, respectively. Endocrine Journal 67(5) 545-559, 2020. doi: 10.1507/endocrj.EJ19-0480
  5. Watanabe, A., Inoue, N., Watanabe, M., Yamamoto, M., Ozaki, H., Hidaka, Y., Iwatani, Y.: Increases of CD80 and CD86 expression on peripheral blood cells and their gene polymorphisms in autoimmune thyroid disease. Immunological Investigations 49(1-2), 191-203, 2020. doi: 10.1080/08820139.2019
  6. Yamamoto, M., Watanabe, M., Inoue, N., Watanabe, A., Ozaki, H., Ohsaki, M., Yidaka, Y., Iwatani, Y.: Association of CD58 polymorphisms and its protein expression with the development and prognosis of autoimmune thyroid diseases. Immunological Investigations, 49(1-2):106-119., 2020. doi: 10.1080/08820139.2019.1659811. 　


(2019年）

  1. Mishima, Y., Brueckner, L., Takahashi, S., Kawakami, T., Otani, J., Shinohara, A., Takeshita, K., Garvilles, R., Watanabe, M., Sakai, N., Takeshima, H., Nachtegael, C., Nishiyama, A., Nakanishi, M., Arita, K., Nakashima, K., Hojo, H., Suetake, I.: Enhanced processivity of Dnmt1 by mono-ubiquitinated histone H3. Genes to Cells doi: 10.1111/gtc.12732.
  2. Hashimoto, H. Watanabe, M., Inoue, N., Hirai, N., Haga, E., Kinoshita, R., Hidaka, Y., Iwatani, Y.: Association of IFNG gene methylation in peripheral blood cells with the development and prognosis of autoimmune thyroid disease. Cytokine 123:154770, 2019 doi: 10.1016/j.cyto.2019.154770
  3. Fukano, H., Takano, T., Fujimoto, Y., Nakatani, R., Watanabe, M., Hidaka, Y., Shimomura, I.: In tube immunocytochemistry for fluorescence-activated cell sorting that prevents RNA degradation in sorted cells. Biotechnic & Histochemistry (published online: 19 Aug 2019). doi: 10.1080/10520295.2019.1632485
  4. Honda, C., Watanabe, M., Tomizawa, R., Osaka Twin Research Group, Sakai, N.: Update on Osaka University Twin Registry: An Overview of Multidisciplinary Research Resources and Biobank at Osaka University Center for Twin Research. Twin Res Hum Genet, 22(6):597-601, 2019. doi: 10.1017/thg.2019.70.
  5. Silventoinen K, Jelenkovic A, Yokoyama Y, Sund R, Sugawara M, Tanaka M,Matsumoto S, Bogl LH, Freitas DL, Maia JA, Hjelmborg JVB, Aaltonen S, Piirtola M, Latvala A, Calais-Ferreira L, Oliveira VC, Ferreira PH, Ji F, Ning F, Pang Z, Ordoñana JR, Sánchez-Romera JF, Colodro-Conde L, Burt SA, Klump KL, Martin NG, Medland SE, Montgomery GW, Kandler C, McAdams TA, Eley TC, Gregory AM, Saudino KJ, Dubois L, Boivin M, Brendgen M, Dionne G, Vitaro F, Tarnoki AD, Tarnoki DL, Haworth CMA, Plomin R, Öncel SY, Aliev F, Medda E, Nisticò L, Toccaceli V, Craig JM, Saffery R, Siribaddana SH, Hotopf M, Sumathipala A, Rijsdijk F, Jeong HU, Spector T, Mangino M, Lachance G, Gatz M, Butler DA, Gao W, Yu C, Li L,Bayasgalan G, Narandalai D, Harden KP, Tucker-Drob EM, Christensen K,Skytthe A, Kyvik KO, Derom CA, Vlietinck RF, Loos RJF, Cozen W, Hwang AE, Mack TM, He M, Ding X, Silberg JL, Maes HH, Cutler TL, Hopper JL,Magnusson PKE, Pedersen NL, Dahl Aslan AK, Baker LA, Tuvblad C,Bjerregaard-Andersen M, Beck-Nielsen H, Sodemann M, Ullemar V, Almqvist C, Tan Q, Zhang D, Swan GE, Krasnow R, Jang KL, Knafo-Noam A, Mankuta D,Abramson L, Lichtenstein P, Krueger RF, McGue M, Pahlen S, Tynelius P,Rasmussen F, Duncan GE, Buchwald D, Corley RP, Huibregtse BM, Nelson TL, Whitfield KE, Franz CE, Kremen WS, Lyons MJ, Ooki S, Brandt I, Nilsen TS, Harris JR, Sung J, Park HA, Lee J, Lee SJ, Willemsen G, Bartels M, van Beijsterveldt CEM, Llewellyn CH, Fisher A, Rebato E, Busjahn A, Tomizawa R, Inui F, Watanabe M, Honda C, Sakai N, Hur YM, Sørensen TIA, Boomsma DI, Kaprio J.: The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins. Twin Res Hum Genet, 31:1-9, 2019. doi: 10.1017/thg.2019.35.
  6. Hirai, N., Watanabe, M., Inoue, N., Kishonita, R., Ohtani, H., Hidaka, Y,. Iwatani, Y.: Association of IL6 gene methylation in peripheral blood cells with the development and prognosis of autoimmune thyroid diseases. Autoimmunity, 52(7-8), 251-255, 2019 doi: 10.1080/08916934.2019.1669568.


（2018年）

  1. Kunisato, T. , Watanabe, M., Inoue, N., Okada, A., Nanba, T., Kobayashi, W., Inoue, Y., Katsumata, Y., Omori, N., Nobuhara, T., Takemura, K., Hidaka, Y., Iwatani, Y: Polymorphisms in Th17-related genes and the pathogenesis of autoimmune thyroid disease. Autoimmunity , 2018. doi: 10.1080/08916934.2018.1534963
  2. Piirtola, N., Jelenkovic, A., Latvala, A., Sund. R., Honda, C., Inui, F., Watanabe, M., Tomizawa, R., Iwatani, Y., Ordoñana, J.R., Sánchez-Romera, J.F., Colodro-Conde, L., Tarnoki, A.D., Tarnoki, D.L., Martin, N.G., Montgomery, G.W., Medland, S.E., Rasmussen, F., Tynelius, P., Tan, Q., Zhang, D., Pang, Z., Rebato, E., Stazi, M.A., Fagnani, C., Brescianini, S., Busjahn, A., Harris. J.R., Brandt, I., Nilsen, T.S., Cutler, T.L., Hopper, J.L., Corley, R.P., Huibregtse, B.M., Sung, J., Kim, J., Lee, J., Lee, S., Gatz, M., Butler, D.A., Franz, C.E., Kremen, W.S., Lyons, M.J., Magnusson, P.K.E., Pedersen, N.L., Aslan, A.K.D., Y Öncel, S., Aliev, F., Derom, C.A., Vlietinck, R.F., Loos, R.J.F., Silberg, J.L., Maes, H.H., Boomsma, D.I., Sørensen, T.I.A., Korhonen, T., Kaprio, J., Silventoinen, K.: Association of current and former smoking with body mass index: a study of smoking discordant twin pairs from 21 twin cohorts. PLOS ONE, 13(7), e020014, 2018. doi: 10.1371/journal.pone.0200140.
  3. Omori, N., Watanabe, M., Inoue, N., Taniguchi, J., Hidaka, Y., Iwatani, Y.: Association of the polymorphisms in Th2 chemotaxis-related genes with the development and prognosis of autoimmune thyroid diseases. Endocrine J 65(8), 815-826, 2018. doi: 10.1507/endocrj.EJ18-0050.
  4. Inoue, N., Watanabe, M., Katsumata, Y., Ishido, N., Hidaka, Y., Iwatani, Y.: Functional polymorphisms of the type 1 and type 2 iodothyronine deiodinase genes in autoimmune thyroid diseases. Immunol Invest, 47(5), 534-542, 2018, doi: 10.1080/08820139.2018.1458861.
  5. Masutani, R., Ikemoto, T., Maki, A., Tanada, H., Iwatani, Y., Watanabe, M., Takubo, T., Okada, Y.: Mean platelet component and mean platelet volume are the useful screening markers of myelodysplastic syndrome. Health Science Reports, 1(5), e50, 2018, doi: 10.1002/hsr2.50
  6. Morita, E., Watanabe, M., Inoue, N., Hashimoto, H., Haga, E., Hidaka, Y., Iwatani, Y.: Methylation levels of the TNFA gene are different between Graves’ and Hashimoto’s diseases and influenced by the TNFA polymorphism. Autoimmunity, 51(3), 118-125, 2018, doi: 10.1080/08916934.2018.1448078.
  7. Tokiyoshi, E., Watanabe, M., Inoue, N., Hidaka, Y., Iwatani, Y: Polymorphisms and expression of genes encoding ARGONAUTES 1 and 2 in autoimmune thyroid diseases. Autoimmunity 51(1), 35-42, 2018, doi: 10.1080/08916934.2017.1416468.
  8. Watanabe, M., Takenaka, Y., Honda, C., Osaka Twin Research Group, Iwatani, Y.: Genotype-based epigenetic differences in monozygotic twins discordant for positive anti-thyroglobulin autoantibodies. Thyroid　28(1): 110-123, 2018, doi:10.1089/thy.2017.0273.


（2017年）

  1. Araki, T., Onishi, M., Yanagisawa, T., Hirata, M., Watanabe, Y., Ogata, S., Hayakawa, K., Honda, C., Watanabe, M., Iwatani, Y., Yorifuji, S.: Frequency-specific genetic influence on inferior parietal lobule activation commonly observed during action observation and execution. Scientific Reports 15;7(1):17660, 2017
  2. Watanabe, M.: Thyroid hormone and autoimmune diseases. In: Akamizu, T., Yamada, M., Yoshimura, H. eds. Thyroid hormone and their related diseases. an extended edition of Journal of the Japan Thyroid Association, 8(2), 161-169, 2017
  3. Suetake, I., Watanabe, M., Takeshita, K., Takahashi, S., Carlton, P.: The molecular basis of DNA methylation. In: DNA and Histone Methylation as Cancer Targets (Cancer Drug Discovery and Development), 19-51, 2017, Humana Press (ISBN-10: 3319597841)
  4. Tomari, S., Watanabe, M., Inoue, N., Mizuma, T., Yamanaka, C., Hidaka, Y., Iwatani, Y.: The polymorphisms in the thyroid peroxidase gene were associated with the development of autoimmune thyroid disease and the serum levels of TPOAb. Endocrine J, 64(10), 1025-1032, 2017 doi: 10.1507/endocrj.EJ17-0191.
  5. Mishima, Y., Brueckner, L., Takahashi, S., Kawakami, T., Arita, K., Oka, S., Otani, J., Hojo, H., Shirakawa, M., Shinohara, A., Watanabe, M., Suetake, I.: RFTS-dependent negative regulation of Dnmt1 by nucleosome structure and histone tails. The FEBS Journal , 284(20), 3455-3469, 2017. doi: 10.1111/febs.14205.
  6. Silventoinen, K. Jelenkovic, A., Latvala, A., Sund, R., Yokoyama, Y., Ullemar, V., Almqvist, C., Derom, C.A., Vlietinck, R.F., Loos, R.JF., Kandler, C., Honda, C., Inui, F., Iwatani, Y., Watanabe, M., Rebato, E., Stazi, M.A., Fagnani, C., Brescianini, S., Hur, Y., Jeong, H., Cutler, T.L., Hopper, J.L., Busjahn, A., Saudino, K.J., Ji, G., Ning, F., Pang, Z., Rose, R.J., Koskenvuo, M., Heikkilä, K., Cozen, W., Hwang, A.E., Mack, T.M., Siribaddana, S.H., Hotopf, M., Sumathipala, A., Rijsdijk, F., Sung, J., Kim, J., Lee, J., Lee, S., Nelson, T.L., Whitfield, K.E., Tan, Q., Zhang, D., Llewellyn, C.H., Fisher, A., Burt, S.A., Klump, K.L., Knafo-Noam, A., Mankuta, D., Abramson, L., Medland, S.E., Martin, N.G., Montgomery, G.W., Magnusson, P.KE., Pedersen, N.L., Aslan, A.K.D., Corley, R.P., Huibregtse, M.M., Öncel, S.Y., Aliev, F., Krueger, R.F., McGue, M., Pahlen, S., Willemsen, G., Bartels, M., van Beijsterveldt, C.EM., Silberg, J.L., Eaves, L.J., Maes, H.H., Harris, J.R., Brandt, I., Nilsen, T.S., Rasmussen, F., Tynelius, P., Baker, L.A., Tuvblad, C., Ordoñana, J.R., Sánchez-Romera, J.F., Colodro-Conde, L., Gatz, M., Butler, D.A., Lichtenstein, P., Goldberg, J.H., Harden, K.P., Tucker-Drob, E.M., Duncan, G.E., Buchwald, D., Tarnoki, A.D., Tarnoki, D.L., Franz, C.E., Kremen, W.S., Lyons, M.J., Maia, J.A., Freitas, D.L>, Turkheimer, E., Sørensen, T.IA., Boomsma, D.I., Kaprio, J.: Education in twins and their parents across birth cohorts over 100 years: an individual-level pooled analysis of 42 twin cohorts. Twin Res Hum Genet, 20(5):395-405, 2017. doi: 10.1017/thg.2017.49.
  7. Takuse, Y., Watanabe, M., Inoue, N., Ozaki, R., Otsu, H., Saeki, M., Katsumata, Y., Hidaka, Y., Iwatani, Y.: Association of IL-10-Regulating MicroRNAs in Peripheral Blood Mononuclear Cells with the Pathogenesis of Autoimmune Thyroid Disease. Immunological Investigation, 46(6), 590-602, 2017. doi: 10.1080/08820139.2017.1322975.
  8. Silventoinen K, Jelenkovic A, Sund R, Yokoyama Y, Hur YM, Cozen W, Hwang AE, Mack TM, Honda C, Inui F, Iwatani Y, Watanabe M, Tomizawa R, Pietiläinen KH, Rissanen A, Siribaddana SH, Hotopf M, Sumathipala A, Rijsdijk F, Tan Q, Zhang D, Pang Z, Piirtola M, Aaltonen S, Öncel SY, Aliev F, Rebato E, Hjelmborg JB, Christensen K, Skytthe A, Kyvik KO, Silberg JL, Eaves LJ, Cutler TL, Ordoñana JR, Sánchez-Romera JF, Colodro-Conde L, Song YM, Yang S, Lee K, Franz CE, Kremen WS, Lyons MJ, Busjahn A, Nelson TL, Whitfield KE, Kandler C, Jang KL, Gatz M, Butler DA, Stazi MA, Fagnani C, D'Ippolito C, Duncan GE, Buchwald D, Martin NG, Medland SE, Montgomery GW, Jeong HU, Swan GE, Krasnow R, Magnusson PK, Pedersen NL, Dahl Aslan AK, McAdams TA, Eley TC, Gregory AM, Tynelius P, Baker LA, Tuvblad C, Bayasgalan G, Narandalai D, Spector TD, Mangino M, Lachance G, Burt SA, Klump KL, Harris JR, Brandt I, Nilsen TS, Krueger RF, McGue M, Pahlen S, Corley RP, Huibregtse BM, Bartels M, van Beijsterveldt CE, Willemsen G, Goldberg JH, Rasmussen F, Tarnoki AD, Tarnoki DL, Derom CA, Vlietinck RF, Loos RJ, Hopper JL, Sung J, Maes HH, Turkheimer E, Boomsma DI, Sørensen TI, Kaprio J.: Differences in genetic and environmental variation in adult body mass index by sex, age, time period, and region: an individual-based pooled analysis of 40 twin cohorts. Am J Clin Nutr. 2017 Jul 5. pii: ajcn153643. doi: 10.3945/ajcn.117.153643.
  9. Mizuma, T., Watanabe, M., Inoue, N., Arakawa, Y., Tomari, S., Hidaka, Y., Iwatani, Y.: Association of the polymorphisms in the gene encoding thyroglobulin with the development and prognosis of autoimmune thyroid disease. Autoimmunity 4:1-7, 2017. doi: 10.1080/08916934.2017.1344971
  10. Inoue, N., Watanabe, M, Nakaguchi, A., ,Ueda, A., Kawaguchi, H., Hidaka, Y., Iwatani, Y.:Functional polymorphisms affecting Th1 differentiation are associated with the severity of autoimmune thyroid diseases. Endocrine J, 64(7), 695-703. doi: 10.1507/endocrj.EJ16-0551.
  11. Wang, T., Jeong, H., Watanabe, M., Iwatani, Y., Ohno, Y.: Fault classification with discriminant analysis during sit-to-stand movement assisted by a nursing care robot. Mechanical Systems and Signal Processing (in press)
  12. Arakawa, Y. Watanabe, M., Takemura, K., Inoue, N., Hidaka, Y., Iwatani, Y.: The IL15 +96522 A>T functional polymorphism is related to the differentiation of Th17 cells and the severity of Hashimoto’s disease. International Journal of Immunogenetics 44(2), 41-50, 2017. doi: 10.1111/iji.12305.
  13. Otsu, H., Watanabe, M., Inoue, N., Masutani, R., Iwatani, Y.: Intraindividual variation of microRNA expression levels in plasma and peripheral blood mononuclear cells and the associations of these levels with the pathogenesis of autoimmune thyroid diseases. Clin Chem Lab Med 55(5), 626-635, 2017. doi: 10.1515/cclm-2016-0449.
  14. Inoue, N., Katsumata, Y., Watanabe, M., Ishido, N., Manabe, Y., Watanabe, A., Masutani, R., Hidaka, Y., Iwatani, Y.: Polymorphisms in and expression of Toll-like receptors in autoimmune thyroid diseases. Autoimmunity , 50(3), 182-191, 2017. doi: 10.1080/08916934.2016.1261835.
  15. Fujii, A., Inoue, N., Watanabe, M., Kawakami, C., Hidaka, Y., Hayashizaki, Y. and Iwatani, Y.: TSHR gene polymorphisms in the enhancer regions are most strongly associated with the development of Graves’ disease, especially intractable disease, and with that of Hashimoto’s disease. Thyroid 27(1), 111-119, 2017. doi: 10.1089/thy.2016.0345.


(2016年）

  1. Maeda, T., Date, A., Watanabe, M., Hidaka, Y., Iwatani, Y., Takano, T.: Optimization of recovery and analysis of RNA in sorted cells in mRNA quantification after fluorescence-activated cell sorting. Ann Clin Lab Sci, 46(6), 435-441, 2016
  2. Jelenkovic, A., Hur, Y., Sund, R., Yokoyama, Y., Siribaddana, S., Hotopf, M., Sumathipala, A., Rijsdijk, F., Tan, Q., Zhang, D., Pang, A., Aaltonen, S., Heikkilä, K., Öncel, S., Aliev, F., Rebato, E., Tarnoki, A., Tarnoki, D., Christensen, K., Skytthe, A., Kyvik, K., Silberg, J., Eaves, L., Maes, H., Cutler, T., Hopper, J., Ordoñana, J., Sánchez-Romera, J., Colodro-Conde, L., Cozen, W., Hwang, A., Mack, T., Sung, J., Song, Y., Yang, S., Lee, K., Franz, C., Kremen, W., Lyons, M., Busjahn, A., Nelson, T., Whitfield, K., Kandler, C., Jang, K., Gatz, M., Butler, D., Stazi, M., Fagnani, C., D'Ippolito, C., Duncan, G., Buchwald, D., Derom, C., Vlietinck, R., Loos, R., Martin, N., Medland, S., Montgomery, G., Jeong, H., Swan, G., Krasnow, R., Magnusson, P., Pedersen, N., Aslan, A., McAdams, T., Eley, T., Gregory, A., Tynelius, P., Baker, L., Tuvblad, C., Bayasgalan, G., Narandalai, D., Lichtenstein, P., Spector, T., Mangino, M., Lachance, G., Bartels, M., Beijsterveldt, T., Willemsen, G., Burt, S., Klump, K., Harris, J., Brandt, I., Nilsen, T., Krueger, R., McGue, M., Pahlen, S., Corley, R., Hjelmborg, J., Goldberg, J., Iwatani, Y., Watanabe, M., Honda, C., Inui, F., Rasmussen, F., Huibregtse, B., Boomsma, D., Sørensen, T., Kaprio, J., Silventoinen, K. : Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994, eLife, 5, 2016. pii: e20320. doi: 10.7554/eLife.20320.
  3. Watanabe, M., Honda, C., The Osaka Twin Research Group, Iwatani, Y.: Within-pair differences of DNA methylation levels between monozygotic twins are different between male and female pairs. BMC Medical Genomics, 9, 55-63, 2016. DOI: 10.1186/s12920-016-0217-2
  4. Saeki, M., Watanabe, M., Inoue, N., Tokiyoshi, E. Takuse, Y., Arakawa, Y. Hidaka, Y., Iwatani, Y.: DICER and DROSHA gene expression and polymorphisms in autoimmune thyroid diseases . Autoimmunity 49(8), 514-522, 2016
  5. Inoue, N., Watanabe, M., Ishido, N., Kodu, A., Maruoka, H., Katsumata, Y., Hidaka, Y., Iwatani, Y.: Involvement of genes encoding apoptosis regulatory factors (FAS, FASL, TRAIL, BCL2, TNFR1 and TNFR2) in the pathogenesis of autoimmune thyroid diseases . Hum Immunol , 77(10), 944-5, 2016
  6. Kagawa, T., Watanabe, M., Inoue, N., Otsu, H., Saeki, M., Katsumata, Y., Takuse, Y., Iwatani, Y.: Increases of microRNA let-7e in peripheral blood mononuclear cells in Hashimoto’s disease. Endocrin J , 63(4), 375-80, 2016
  7. Sarumaru, M., Watanabe, M., Inoue, N., Hisamoto, Y., Morita, E., Arakawa, Y., Hidaka, Y., Iwatani, Y.:Association between functional SIRT1 polymorphisms and the clinical　characteristics of patients with autoimmune thyroid disease. Autoimmunity, 31:1-9, 2016
  8. Akahane, M., Watanabe, M., Inoue, N., Miyahara, Y., Arakawa, Y., Inoue, Y., Katsumata, Y., Hidaka, Y., Iwatani, Y.: Association of the polymorphisms of chemokine genes (IL8, RANTES, MIG, IP10, MCP1 and IL16) with the pathogenesis of autoimmune thyroid diseases . Autoimmunity 31, 1-8, 2016
  9. Yoshie, N., Watanabe, M., Inoue, N., Kawaguchi, H., Hidaka, Y., Iwatani, Y.: Association of polymorphisms in the ICOS and ICOSL genes with the pathogenesis of autoimmune thyroid diseases. Endocrin J, 63(1), :61-8, 2016

(2015年）

  1. Jelenkovic A, Yokoyama Y, Sund R, Honda C, Bogl LH, Aaltonen S, Ji F, Ning F, Pang Z, Ordoñana JR, Sánchez-Romera JF, Colodro-Conde L, Burt SA, Klump KL, Medland SE, Montgomery GW, Kandler C, McAdams TA, Eley TC, Gregory AM, Saudino KJ, Dubois L, Boivin M, Tarnoki AD, Tarnoki DL, Haworth CM, Plomin R, Öncel SY, Aliev F, Stazi MA, Fagnani C, D'Ippolito C, Craig JM, Saffery R, Siribaddana SH, Hotopf M, Sumathipala A, Rijsdijk F, Spector T, Mangino M, Lachance G, Gatz M, Butler DA, Bayasgalan G, Narandalai D, Freitas DL, Maia JA, Harden KP, Tucker-Drob EM, Kim B, Chong Y, Hong C, Shin HJ, Christensen K, Skytthe A, Kyvik KO, Derom CA, Vlietinck RF, Loos RJ, Cozen W, Hwang AE, Mack TM, He M, Ding X, Chang B, Silberg JL, Eaves LJ, Maes HH, Cutler TL, Hopper JL, Aujard K, Magnusson PK, Pedersen NL, Aslan AK, Song YM, Yang S, Lee K, Baker LA, Tuvblad C, Bjerregaard-Andersen M, Beck-Nielsen H, Sodemann M, Heikkilä K, Tan Q, Zhang D, Swan GE, Krasnow R, Jang KL, Knafo-Noam A, Mankuta D, Abramson L, Lichtenstein P, Krueger RF, McGue M, Pahlen S, Tynelius P, Duncan GE, Buchwald D, Corley RP, Huibregtse BM, Nelson TL, Whitfield KE, Franz CE, Kremen WS, Lyons MJ, Ooki S, Brandt I, Nilsen TS, Inui F, Watanabe M, Bartels M, van Beijsterveldt TC, Wardle J, Llewellyn CH, Fisher A, Rebato E, Martin NG, Iwatani Y, Hayakawa K, Sung J, Harris JR, Willemsen G, Busjahn A, Goldberg JH, Rasmussen F, Hur YM, Boomsma DI, Sørensen TI, Kaprio J, Silventoinen K.: Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age: A Study of the CODATwins Project. Twin Res Hum Genet. 557-70, 2015. [doi: 10.1017/thg.2015.57.]
  2. Silventoinen K, Jelenkovic A, Sund R, Honda C, Aaltonen S, Yokoyama Y, Tarnoki AD, Tarnoki DL, Ning F, Ji F, Pang Z, Ordoñana JR, Sánchez-Romera JF, Colodro-Conde L, Burt SA, Klump KL, Medland SE, Montgomery GW, Kandler C, McAdams TA, Eley TC, Gregory AM, Saudino KJ, Dubois L, Boivin M, Haworth CM, Plomin R, Öncel SY, Aliev F, Stazi MA, Fagnani C, D'Ippolito C, Craig JM, Saffery R, Siribaddana SH, Hotopf M, Sumathipala A, Spector T, Mangino M, Lachance G, Gatz M, Butler DA, Bayasgalan G, Narandalai D, Freitas DL, Maia JA, Harden KP, Tucker-Drob EM, Christensen K, Skytthe A, Kyvik KO, Hong C, Chong Y, Derom CA, Vlietinck RF, Loos RJ, Cozen W, Hwang AE, Mack TM, He M, Ding X, Chang B, Silberg JL, Eaves LJ, Maes HH, Cutler TL, Hopper JL, Aujard K, Magnusson PK, Pedersen NL, Aslan AK, Song YM, Yang S, Lee K, Baker LA, Tuvblad C, Bjerregaard-Andersen M, Beck-Nielsen H, Sodemann M, Heikkilä K, Tan Q, Zhang D, Swan GE, Krasnow R, Jang KL, Knafo-Noam A, Mankuta D, Abramson L, Lichtenstein P, Krueger RF, McGue M, Pahlen S, Tynelius P, Duncan GE, Buchwald D, Corley RP, Huibregtse BM, Nelson TL, Whitfield KE, Franz CE, Kremen WS, Lyons MJ, Ooki S, Brandt I, Nilsen TS, Inui F, Watanabe M, Bartels M, van Beijsterveldt TC, Wardle J, Llewellyn CH, Fisher A, Rebato E, Martin NG, Iwatani Y, Hayakawa K, Rasmussen F, Sung J, Harris JR, Willemsen G, Busjahn A, Goldberg JH, Boomsma DI, Hur YM, Sørensen TI, Kaprio J.: The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits. Twin Res Hum Genet. 27, 1-13, 2015. [doi: 10.1017/thg.2015.29.]
  3. Inoue, N., Watanabe, M., Katsumata, Y., Ishido, N., Hidaka, Y., Iwatani, Y.: Association between functional polymorphisms in the Toll-like receptor 4 (TLR4) gene and HD severity. Tissue Antigens 85(3), 209-11, 2015 [doi: 10.1111/tan.12518]
  4. Ishido,N., Inoue, N., Watanabe, M., Hidaka, Y., Iwatani, Y.: The Relationship between Skewed X Chromosome Inactivation and the Prognosis of Graves' and Hashimoto's Diseases Thyroid , 25(2), 256-61, 2015. [doi: 10.1089/thy.2014.0318]
  5. Shimasue, A., Yamakawa, N., Watanabe, M., Hidaka, Y., Iwatani, Y., Takano, T.: Expression Analysis of Stemness Genes in a Rat Thyroid Cell Line FRTL5 Exp Clin Endocrinol Diabetes, 123(1), 48-54, 2015. [doi: 10.1055/s-0034-1389924]
  6. Kobayashi, E., Deguchi, M., Kagita, M., Yoshioka, N., Kita, M., Asari, S., Suehisa, E., Hidaka, Y., Iwatani, Y.: Performance evaluation of four dominant anti-hepatitis B core antigen (HBcAb) kits in Japan for preventing de novo hepatitis B virus (HBV) infection, Clin Lab. 61(1-2), 77-85, 2015
  7. Takeda, M., Funato, T., Ikemoto, M., Nanmoku, T., Urasaki, Y., Iwatani, Y.: Clinical usefulness of the PAXgene™ bone marrow RNA system for stabilizing total RNA J Clin Lab Anal, 29(1), 61-7, 2015 [doi: 10.1002/jcla.21729]

(2014年）

  1. Inoue, N., Watanabe, M., Ishido, N., Katsumata, Y., Kagawa, T., Hidaka, Y., Iwatani, Y.:The functional polymorphisms of VDR, GC and CYP2R1 are involved in the pathogenesis of autoimmune thyroid diseases. Clin Exp Immunol 178(2), 262-269, 2014
  2. Inoue, Y., Watanabe, M., Inoue, N., Kagawa, T., Shibutani, S., Otsu, H., Saeki, M., Takuse, Y., Hidaka, Y., Iwatani, Y.: Associations of single nucleotide polymorphisms in pri-miR-125a and the expression of mature miR-125a with the development and prognosis of autoimmune thyroid diseases. Clin Exp Immunol 178(2) 229-235
  3. Date A., Maeda T., Watanabe M., Hidaka Y., Iwatani Y., Takano T.: An improved protocol for mRNA quantification after fluorescence-activated cell sorting with an increased signal to noise ratio in flow cytometry. Mol Biotechnol. 56(7), 591-8, 2014 [doi: 10.1007/s12033-014-9733-5]
  4. Sunada, A., Kimura, K., Nishi, I., Toyokawa, M., Ueda, A., Sakata, T., Suzuki, T., Inoue, Y., Ohashi, Y., Asari, S., Iwatani, Y.: In vitro evaluations of topical agents to treat Acanthamoeba keratitis, Ophthalmology, 121(10), 2059-65, 2014 [doi: 10.1016/j.ophtha.2014.04.013]

(2013年）

  1. Kishino,Y., Tanaka, Y., Ikeda, T., Yamamoto, K., Ogawa, H., Iwatani, Y., Kamisako, T.:Ezetimibe increases hepatic iron levels in mice fed a high-fat diet. J Pharmacol Exp Ther 345(3), 483-91, 2013 [doi: 10.1124/jpet.113.203448]
  2. Inoue, N. Watanabe, M., Nobuhara, T., Hidaka, Y., Iwatani, Y.:The GG genotype of the 1125G/T polymorphism in the EPO gene protects against the development of Graves' disease. Immunol Letters, 156(1-2), 156-8, 2013 [doi: 10.1016/j.imlet.2013.10.006]
  3. Inoue, N., Watanabe, M., Katsumata, Y., Hidaka, Y., Iwatani, Y: Different genotypes of a functional polymorphism of the TSHR gene are associated with the development and severity of Graves and Hashimotos diseases. Tissue Antigen, 82(4), 288-90, 2013 [doi: 10.1111/tan.12190]
  4. Inoue, N., Watanabe, M., Wada, M., Morita, M., Hidaka, Y., Iwatani, Y. IL-10 -592A/C polymorphism is associated with severity of Hashimoto's disease. Cytokine , 64(1), 370-4, 2013 [doi: 10.1016/j.cyto.2013.05.014]
  5. Matsumoto, C., Ito, M., Yamada, H., Yoshida, H., Watanabe, M., Hidaka, Y., Iwatani, Y., Miyauchi, A., Takano, T: Preparation of thyroid follicular cells for mRNA quantifi cation after fl uorescence-activated cell sorting. Scandinavian Journal of Clinical & Laboratory Investigation, 73, 245–252, 2013 [doi: 10.3109/00365513.2013.769624]
  6. Inoue, N., Watanabe, M., Hayashi F., Hidaka, Y., Iwatani, Y.: The association between a functional polymorphism in the CD24 gene and the development of autoimmune thyroid diseases. Tissue Antigen, 81(3), 161-3, 2013 [doi: 10.1111/tan.12070]
  7. Hayakawa, K., Iwatani, Y.: An overview of multidisciplinary research resorces at the Osaka University Center for Twin Research. Twin Res Hum genet, 2013 [doi: 10.1017/thg.2012.141]
  8. Matsumoto, C., Ito, M., Yamada, H., Yamakawa, N., Yoshida, H., Date, A., Watanabe, M., Hidaka, Y., Iwatani, Y., Miyauchi, A., Takano, T.: Genes that characterize T3-predominant Graves' thyroid tissues. Eur J Endocrinol, 168(2), 137-44, 2013 [doi: 10.1530/EJE-12-0507]
  9. Nagase, S., Kohguchi, K., Tohyama, K., Watanabe, M., Iwatani, Y.: Interference by Pralidoxime (PAM) salts in clinical laboratory tests. Clin Chim Acta, 416:72-79, 2013 [doi: 10.1016/j.cca.2012.11.017]

(2012年)

  1. Arakawa,Y., Watanabe, M., Inoue, N., Sarumaru, M., Hidaka, Y., Iwatani, Y.: Association ofpolymorphisms in DNMT1, DNMT3A, DNMT3B, MTHFR, and MTRR genes with global DNA methylation levels and prognosis of autoimmune thyroid disease. Clin Exp Immunol, 170(2):194-201, 2012 [doi: 10.1111/j.1365-2249.2012.04646.x]
  2. Inoue, N. Watanabe, M., Yamada, H., Takemura, K., Hayashi, F., Yamakawa, N., Akahane, M., Shimizuishi, Y., Hidaka, Y., Iwatani, Y.: Associations between autoimmune thyroid disease prognosis and functional polymorphisms of susceptibility genes, CTLA4, PTPN22, CD40, FCRL3, and ZFAT, previously revealed in Genome-wide association studies. J Clin Immunol, 32(6), 1243-52, 2012 [doi: 10.1007/s10875-012-9721-0]
  3. Yamada, H., Takano, T., Kihara, M., Hirokawa, M., Yoshida, H., Watanabe, M., Iwatani, Y., Hidaka, Y., Miyauchi, A.: Masurement of TFF3 mRNA in aspirates from thyroid nodules using mesh filtration: The first clinical trial in 130 cases. Endocrine J, 59(7),621-30, 2012 Apr 26 online. [doi:10.1507/endocrj.EJ12-0077]
  4. Yamada, H., Yamakawa, N., Watanabe, M., Hidaka, Y., Iwatani, Y., Takano, T.: Prolonged hybridization with a cRNA probe improves the signal to noise ratio for in-tube in situ hybridization for quantification of mRNA after fluorescence-activated cell sorting. Biotech Histochem, 87(5), 366-71, 2012 [doi:10.3109/10520295.2012.672650]
  5. Morita, M., Watanabe, M., Inoue, N., Inaoka, C., Akamizu, T., Tatsumi, K., Hidaka, Y., Iwatani, Y.: Functional polymorphisms in TBX21 and HLX are associated with development and prognosis of Graves' disease. Autoimmunity, 45(2), 129-36, 2012 [doi:10.3109/08916934.2011.622013]
  6. Hanada, H., Mugii, S., Takeoka, K., Maeda, I., Watanabe, M., Hidaka, Y., Iwatani, Y.: Preparation of a cut-off solution that gives a clear index for distinguishing Le(a-b-) sera in CA19-9 assays using SphereLight 180 and Architect i2000 kits. Clinica Chemica Acta, 413(1-2), 278-281, 2012

(2011年）

  1. Tomizawa, R., Watanabe, M., Inoue N., Takemura, K., Hidaka, Y., Akamizu, T., Hayakawa, K., Iwatani, Y.: Association of functional GITR gene polymorphisms related to expression of GITR molecules with prognosis of autoimmune thyroid disease. Clin Exp Immunol, 165(2), 141-147, 2011
  2. Inoue, N., Watanabe, M., Morita, M., Tatsumi, K., Hidaka, Y., Akamizu, T., Iwatani, Y.: Association of functional polymorphisms in promoter regions of IL5, IL6, and IL13 genes with development and prognosis of autoimmune thyroid diseases. Clin Exp Immunol, 163(3), 318-323, 2011
  3. Maruo, R., Yamada, H., Watanabe, M., Hidaka, Y., Iwatani, Y. Takano, T.: mRNA quantification after fluorescence activated cell sorting using locked nucleic acid probes. Mol Biotechnol, 49(1), 42-47, 2011
  4. Yamada, H., Takano, T., Matsuzuka, F., Watanabe, M., Miyauchi, A., Iwatani, Y.: Transcriptional activity of the 5'-flanking region of the thyroid transcription factor-1 gene in human thyroid cell lines. Genet Mol Biol, 34(1), 6-10, 2011
  5. Nishi, I., Sunada, A., Toyokawa, M., Asari, S., Iwatani, Y.: Evaluation of amphotericin B and micafungin combination against clinical isolates of Aspergillus species. J Chemother, 23(2):102-6, 2011

（2010年）

  1. Inoue, N., Watanabe, M., Morita, M., Tomizawa, R., Akamizu, T., Tatsumi, K., Hidaka, Y., Iwatani, Y.: Association of functional polymorphisms related to the transcriptional level of FOXP3 with prognosis of autoimmune thyroid diseases. Clin Exp Immunol, 162(3), 402-406, 2010
  2. Yamada, H., Maruo, R., Watanabe, M., Hidaka, Y., Iwatani, Y., Takano, T.: Messenger RNA quantification after fluorescence activated cell sorting using in situ hybridization. Cytometry Part A, 77(11), 1032-1037, 2010
  3. Yamada, H., Maruo, R., Watanabe, M., Hidaka, Y., Iwatani, Y., Takano, T.: Messenger RNA quantification after fluorescence activated cell sorting using intracellular antigens. Biochem Biophys Res Commun. 397(3), 425-428, 2010
  4. Kuromoto, K., Watanabe, M., Adachi, K., Ohashi, K., Iwatani, Y.: Increases in urinary creatinine and blood pressure during early pregnancy in preeclampsia. Ann Clin Biochem, 47(Pt 4), 336-342, 2010
  5. Kuroda, S., Watanabe, M., Santo, T., Shimizuishi, Y., Takano, T., Hidaka, Y., Kimura, T., Iwatani, Y.: Postpartum increase of serum thioredoxin concentrations and the relation to CD8 lymphocytes. Ann Clin Biochem 47(Pt 1), 62-66, 2010

(2009年)

  1. Hayashi, F., Watanabe, M., Nanba, T., Inoue, N., Akamizu, T., Iwatani, Y.: Association of -31C/T functional polymorphism in the interleukin-1beta gene with the intractability of Graves’ disease and the proportion of Th17 cells. Clin Exp Immunol 158(3), 281-286,2009
  2. Hanada, H., Mugii, S, Takeoka, K., Maeda, I, Watanabe, M., Hidaka, Y., Iwatani, Y.: Early detection of metastasis and relapse of colorectal cancer by recognizing NCA-2 in commercially available CEA assay. Clin Chem, 55(9), 1747-1751, 2009
  3. Nanba, T., Watanabe, M., Inoue, N., Iwatani, Y.: Increases of the Th1/Th2 cell ratio in severe Hashimoto's disease and in the proportion of Th17 cells in intractable Graves' disease. Thyroid 19(5), 495-501, 2009
  4. Yamada H., Takano, T., Ito, Y., Matsuzuka, F., Miya, A., Kobayashi, K., Yoshida, H., Watanabe, M., Iwatani, Y., Miyauchi, A.:Expression of nestin mRNA is a differentiation marker in thyroid tumors. Cancer Lett 280(1):61-4, 2009
  5. Inoue, N., Watanabe, M., Nanba, T., Wada, M., Akamizu, T., Iwatani, Y.: Involvement of functional polymorphisms in the TNFA gene in the pathogenesis of autoimmune thyroid diseases and production of anti-TSH receptor antibody. Clin Exp Immunol 156(2), 199-204, 2009
  6. Nojima J, Iwatani Y, Ichihara K, Ishikawa T, Tsuneoka H, Yanagihara M, Takano T, Hidaka Y. Acquired activated protein C resistance is associated with IgG antibodies to protein S in patients with systemic lupus erythematosus. Thromb Res, 124(1), 127-131, 2009
  7. Kita，M., Deguchi, M.，Kagita，M., Yoshioka, N.，Kobayashi, E., Watanabe, M., Asari, S.，Yamanaka, K.，Iwatani, Y.: Clinical utility and characteristics of nine anti-HCV antibody screening reagents used in Japan. Clinical Laboratory 55, 9-22, 2009
  8. Nishi, I., Sunada, A., Toyokawa, M., Asari, S., Iwatani, Y.: In vitro antifungal combination effects of micafungin with fluconazole, voriconazole, amphotericin B, and flucytosine against clinical isolates of Candida species. J Infect Chemother, 15(2):123-4, 2009

(2008年)

  1. Nojima J, Masuda Y, Iwatani Y, Kuratsune H, Watanabe Y, Suehisa E, Takano T, Hidaka Y, Kanakura Y. Arteriosclerosis obliterans associated with anti-cardiolipin antibody / beta2-glycoprotein I antibodies as a strong risk factor for ischaemic heart disease in patients with systemic lupus erythematosus. Rheumatology (Oxford) 47, 684-9, 2008
  2. Nanba, T., Watanabe, M., Akamizu, T., Iwatani, Y.: The -590CC genotype in interleukin-4 gene as a strong predictive factor for the development of hypothyroidism in Hashimoto's disease. Clin Chem 54(3), 621-623, 2008
  3. Watanabe, M., Nakamura, Y., Matsuzuka, F., Takamura, Y., Miyauchi, A., Iwatani, Y.: Decrease of intrathyroidal CD161+Valpha24+Vbeta11+ NKT cells in Graves’ disease. Endocrine J 55(1), 199-203, 2008
  4. Hatanaka, N., Yamamoto, Y., Ichihara, K., Sato, A., Chihara, K., Nakamura, Y., Watanabe, M., Iwatani, Y.: A new predictive indicator for development of pressure ulcer in bedridden patients based on common laboratory tests results. J Clin Pathol 61(4), 514-8, 2008
  5. Yamada, H., Watanabe, M., Nanba, T., Akamizu, T., Iwatani, Y.: The 869T/C polymorphism in the transforming growth factor-beta1 gene is associated with the severity and intractability of autoimmune thyroid disease. Clin Exp Immunol 151(3), 379-82, 2008
  6. Nojima J, Masuda Y, Iwatani Y, Suehisa E, Futsukaichi Y, Kuratsune H, Watanabe Y, Takano T, Hidaka Y, Kanakura Y. Tissue factor expression on monocytes induced by anti-phospholipid antibodies as a strong risk factor for thromboembolic complications in SLE patients. Biochem Biophys Res Commun 365:195-200, 2008

(2007年)

  1. Santoh, T., Watanabe, M., Kuroda, S., Ueda, D., Iwatani, Y.: Ratio of serum IgG3 to total IgG concentration ond goiter size are independent factors in intractability of Graves' disease. Endocrine J 54(6), 887-894, 2007
  2. Yoshioka, N., Deguchi, M., Kagita, M., Kita, M., Watanabe, M., Asari, S., Iwatani, Y.: Evaluation of a chemiluminescent microparticle immunoassay for determination of Treponema pallidum antibodies. Clin Lab 53, 597-603, 2007
  3. Yamanishi H, Imai N, Suehisa E, Kanakura Y, Iwatani Y. Determination of leukocyte counts in cerebrospinal fluid with a disposable plastic hemocytometer. J Clin Lab Anal 21:282-5, 2007
  4. Tamura K, Nakajima S, Hirota Y, Takahashi KA, Fujioka M, Kubo T, Iwatani Y, Ozono K. Genetic association of a polymorphism of the cAMP-responsive element binding protein-binding protein with steroid-induced osteonecrosis after kidney transplantation. J Bone Miner Metab 25:320-5, 2007
  5. Kabutomori O, Kanakura Y, Iwatani Y. Characteristic Changes in Platelet-Large Cell Ratio, Lactate Dehydrogenase and C-Reactive Protein in Thrombocytosis-Related Diseases. Acta Haematol 118:84-87, 2007
  6. Yamanishi H, Kimura S, Hata N, Iyama S, Kanakura Y, Iwatani Y: Evaluation of a model of latent pathologic factors in relation to serum ferritin elevation. Clin Biochim 40:359-364, 2007
  7. Nakano A, Watanabe M, Iida T, Kuroda S, Matsuzuka F, Miyauchi A, Iwatani Y: Apoptosis induced decrease of intrathyroidal CD4+CD25+ regulatory T cells in autoimmune thyroid diseases. Thyroid, 17(1), 25-31, 2007

(2006年)

  1. Ito C, Watanabe M, Okuda N, Watanabe C, Iwatani Y: Association between the severity of Hashimoto’s disease and the functional +874A/T polymorphism in the interferon-gamma gene. Endocrine J 53, 473-478, 2006
  2. Kojima F, Nakagami Y, Takemori K, Iwatani Y, Fujimoto S: Penicillin susceptibility of non-serotypeable Streptococcus pneumoniae from ophthalmic specimens. J Antimicrob Chemother J Antimicrob Chemother 12:199-202, 2006
  3. Yamanishi H, Imai N, Ohmine T, Nishiyama M, Suehisa E, Kanakura Y, Iwatani Y: Urine flow cytometer quantification of leukocytes in samples containing a large proportion of lymphocytes. Clin Biochem 39:857-9, 2006
  4. Tamechika Y, Iwatani Y, Tohyama K, Ichihara K: Insufficient filling of vacuum tubes as a cause of microhemolysis and elevated serum lactate dehydrogenase levels. Use of a data-mining technique in evaluation of questionable laboratory test results. Clin Chem Lab Med 44:657-661, 2006
  5. Nojima J, Iwatani Y, Suehisa E, Kuratsune H, Kanakura Y: The presence of anti-phosphatidylserine/prothrombin antibodies as risk factor for both arterial and venous thrombosis in patients with systemic lupus erythematosus. Thrombosis 91:699-702, 2006

(2005年)

  1. Nagahama D, Yoshiko K, Watanabe M, Morita Y, Iwatani Y, Matsuo S: A useful new classification of dysmorphic urinary erythrocytes.  Clin Exp Nephrol 9:304-9, 2005
  2. Kabutomori O, Kanakura Y, Iwatani Y: Inflammation and liver dysfunction. Ann Hematol 84:136, 2005
  3. Nojima J, Kuratsune H, Suehisa E, Iwatani Y, Kanakura Y: Acquired activated protein C resistance associated with IgG antibodies against beta2-glycoprotein I and prothrombin as a strong risk factor for venous thromboembolism. Clin Chem 51:545-52, 2005
  4. Hiratani H, Bowden DW, Ikegami S, Shirasawa S, Shimizu A, Iwatani Y, Akamizu T: Multiple SNPs in intron 7 of thyrotropin receptor are associated with Graves' disease. J Clin Endocrinol Metab 90:2898-903, 2005

(2004年)

  1. Nakamura, Y. Watanabe, M. Matsuzuka, F. Miyauchi, A. Iwatani, Y Intrathyroidal CD4+ T lymphocytes express high levels of Fas and CD4+CD8+ macrophages / dendritic cells express Fas ligand in autoimmune thyroid disease. Thyroid 14(10): 819-824, 2004
  2. Nojima J, Kuratsune H, Suehisa E, Kitani T, Iwatani Y, Kanakura Y.　2004 Strong correlation between the prevalence of cerebral infarction and the presence of anti-cardiolipin/beta2-glycoprotein I and anti-phosphatidylserine/prothrombin antibodies - Co-existence of these antibodies enhances ADP-induced platelet activation in vitro. Thromb Haemost 91:967-76
  3. Hayashi S, Ichihara K, Kanakura Y, Iwatani Y. 2004 A new quality control method based on a moving average of “latent reference values” selected from patients’ daily test results. Rinsho Byori 52:204-211
  4. Deguchi M, Yamashita N, Kagita M, Asari S, Iwatani Y, Tsuchida T, Iinuma K, Mushahwar IK 2004 Quantitation of Hepatitis B Surface Antigen by an Automated Chemiluminescent Microparticle Immunoassay. J Virol Methods 115:217-222
  5. Yamamoto, N. Watanabe, M. Matsuzuka, F. Miyauchi, A. Iwatani, Y 2004 Lower concentration of serum soluble CD8 in severe Hashimoto's disease. Clin Exp Immunol 137: 601-605
  6. Watanabe M. Yamamoto N. Matsuzuka F. Miyauchi A. Iwatani Y. 2004 Decrease of CD154 intensity on peripheral CD4+ T cells in autoimmune thyroid disease. Clin Exp Immunol 136:555-558
  7. Maruoka H. Watanabe M. Matsuzuka F. Takimoto T. Miyauchi A. Iwatani Y. 2004 Increased intensities of Fas expression on peripheral T cell subsets in severe autoimmune thyroid disease. Thyroid 14(6): 417-423
  8. Takeoka K, Watanabe M, Matsuzuka F, Miyauchi A, Iwatani Y. 2004 Increase of serum Interleukin-10 in intractable Graves' disease. Thyroid 14:201-205

(2003年)

  1. Yamanishi H, Iyama S, Yamaguchi Y, Kanakura Y, Iwatani Y 2003 Total iron-binding capacity calculated from serum transferrin concentration or serum iron concentration and unsaturated iron-binding capacity. Clin Chem 49:175-8.
  2. Yamanishi H, Iyama S, Yamaguchi Y, Kanakura Y, Iwatani Y 2003 Modification of the colorimetric assay for serum unsaturated iron-binding capacity. Clin Chem 49:1023-5.
  3. Yamamoto S, Iwasaki Y, Mino N, Watanabe M 2003 Basic study on human psychological and physiological characteristics in responses to existing plants in urban parks. Journal of the Japanese Institute of Landscape Architecture, International Edition 2, 25-30,
  4. Watanabe M, Yamamoto N, Maruoka H, Matsuzuka F, Miyauchi A, Iwatani Y 2003 Relation of CD30 molecules on T-cell subsets to the severity of autoimmune thyroid disease. Thyroid 13:259-63.
  5. Toyokawa M, Asari S, Nishi I, Horikawa M, Tsukamoto H, Sunada A, Ueda A, Iwatani Y 2003 In vitro combined effects of cefozopran/teicoplanin and cefozopran/vancomycin on methicillin-resistant Staphylococcus aureus. J Chemother 15:31-6.
  6. Shinoda R, Watanabe M, Nakamura Y, Maruoka H, Kimura Y, Iwatani Y 2003 Physiological changes of Fas expression in peripheral lymphocyte subsets during the menstrual cycle. J Reprod Immunol 60:159-68.
  7. Nakamoto Y, Niki M, Watanabe M, Iwatani Y 2003 Increase in immunoglobulin g3-secreting cells in intractable graves' disease. Thyroid 13:325-31.
  8. Komatsu M, Aihara M, Shimakawa K, Iwasaki M, Nagasaka Y, Fukuda S, Matsuo S, Iwatani Y 2003 Evaluation of MicroScan ESBL confirmation panel for Enterobacteriaceae-producing, extended-spectrum beta-lactamases isolated in Japan. Diagn Microbiol Infect Dis 46:125-30.
  9. Komatsu M, Kato H, Aihara M, Shimakawa K, Iwasaki M, Nagasaka Y, Fukuda S, Matsuo S, Arakawa Y, Watanabe M, Iwatani Y 2003 High Frequency of Antibiotic-Associated Diarrhea due to Toxin A-Negative, Toxin B-Positive Clostridium difficile in a Hospital in Japan and Risk Factors for Infection. Eur J Clin Microbiol Infect Dis
  10. Kabutomori O, Kanakura Y, Iwatani Y 2003 Incorrect measurement of leukocyte counts in post-bone marrow transplantation (P-BMT) patients. Ann Hematol 82:529-30.
  11. Kabutomori O, Kanakura Y, Iwatani Y 2003 Marked decreases of total and immature reticulocytes in myelodysplastic syndrome among patients with pancytopenia. Acta Haematol 109:212-3.
  12. Asari S, Deguchi M, Tahara K, Taniike M, Toyokawa M, Nishi I, Watanabe M, Iwatani Y, Makimoto K 2003 Seroprevalence survey of measles, rubella, varicella, and mumps antibodies in health care workers and evaluation of a vaccination program in a tertiary care hospital in Japan. Am J Infect Control 31:157-62.

(2002年)

  1. Yamanishi H, Iyama S, Yamaguchi Y, Kanakura Y, Iwatani Y 2002 Modification of fully automated total iron-binding capacity (TIBC) assay in serum and comparison with dimension TIBC method. Clin Chem 48:1565-70.
  2. Yamanishi H, Iyama S, Yamaguchi Y, Kanakura Y, Iwatani Y 2002 Relation between iron content of serum ferritin and clinical status factors extracted by factor analysis in patients with hyperferritinemia. Clin Biochem 35:523-9.
  3. Watanabe M, Yamamoto N, Maruoka H, Tamai H, Matsuzuka F, Miyauchi A, Iwatani Y 2002 Independent involvement of CD8+ CD25+ cells and thyroid autoantibodies in disease severity of Hashimoto's disease. Thyroid 12:801-8.
  4. Nojima J, Kuratsune H, Suehisa E, Kawasaki T, Machii T, Kitani T, Iwatani Y, Kanakura Y 2002 Acquired activated protein C resistance is associated with the co-existence of anti-prothrombin antibodies and lupus anticoagulant activity in patients with systemic lupus erythematosus. Br J Haematol 118:577-83.
  5. Nojima J, Kuratsune H, Suehisa E, Kawasaki T, Machii T, Kitani T, Iwatani Y, Kanakura Y 2002 Acquired activated protein C resistance associated with anti-protein S antibody as a strong risk factor for DVT in non-SLE patients. Thromb Haemost 88:716-22.
  6. Kabutomori O, Kanakura Y, Iwatani Y 2002 Movement of toxic granulation neutrophils and C-reactive protein in inflammatory processes. Am J Med 112:595-6.
  7. Kabutomri O, Kanakura Y, Iwatani Y 2002 Induction of toxic granulation in neurophils by granulocyte colony-stimulating factor. Eur J Haematol 69: 187-8

(2001年)

  1. Watanabe K, Watanabe M, Maruoka H, Amino N, Iwatani Y 2001 Increase of CD5+ B cells during adolescence in female mice. Mech Ageing Dev 122:1787-95.
  2. Nojima J, Kuratsune H, Suehisa E, Futsukaichi Y, Yamanishi H, Machii T, Iwatani Y, Kanakura Y 2001 Association between the prevalence of antibodies to beta(2)-glycoprotein I, prothrombin, protein C, protein S, and annexin V in patients with systemic lupus erythematosus and thrombotic and thrombocytopenic complications. Clin Chem 47:1008-15.
  3. Nojima J, Kuratsune H, Suehisa E, Futsukaichi Y, Yamanishi H, Machii T, Kitani T, Iwatani Y, Kanakura Y 2001 Anti-prothrombin antibodies combined with lupus anti-coagulant activity is an essential risk factor for venous thromboembolism in patients with systemic lupus erythematosus. Br J Haematol 114:647-54.
  4. Kabutomori O, Iwatani Y 2001 Phagocytosis decreases the density of IgG-Fc receptor III on neutrophils. Ann Hematol 80:443-4.
  5. Kabutomori O, Kanakura Y, Iwatani Y 2001 Increase in platelet-large cell ratio in chronic myeloid leukemia. Leuk Res 25:873.

(2000年以前)

  1. Kabutomori O, Iwatani Y, Kanakura Y, Kabutomuri O 2000 Toxic granulation neutrophils and C-reactive protein. Arch Intern Med 160:3326-7.
  2. Iwatani Y, Watanabe M 1999 Normal mechanisms for self-tolerance. In Autoimmune Endocrinopathies (edited by Volpe R.), Humana Press, INC., Totawa, 1-30
  3. Kabutomori O, Iwatani Y, Kabutomori M 1999 Effects of hypertriglyceridemia on platelet counts in automated hematologic analysis. Ann Intern Med 130:452.
  4. Kabutomori O, Yanagihara T, Iwatani Y, Kawarazaki A, Kabutomori M 1999 Sex difference in myeloperoxidase activity of neutrophils. Am J Hematol 60:312-3.
  5. Iwatani Y, Watanabe M 1998 The maternal immune system in health and disease. Curr Opin Obstet Gynecol 10:453-8.
  6. Watanabe M, Iwatani Y, Kaneda T, Hidaka Y, Mitsuda N, Morimoto Y, Amino N 1997 Changes in T, B, and NK lymphocyte subsets during and after normal pregnancy. Am J Reprod Immunol 37:368-77.
  7. Watanabe M, Amino N, Hochito K, Watanabe K, Kuma K, Iwatani Y 1997 Opposite changes in serum soluble CD8 in patients at the active stages of Graves' and Hashimoto's diseases. Thyroid 7:743-7.
  8. Kabutomori O, Iwatani Y, Koh T, Yanagihara T 1997 CD16 antigen density on neutrophils in chronic myeloproliferative disorders. Am J Clin Pathol 107:661-4.
  9. Kabutomori O, Iwatani Y 1997 Unusual eosinophilia not detected by an automated haematological analyser in a patient with liver cirrhosis. J Clin Pathol 50:967-9.
  10. Watanabe M, Iwatani Y, Hidaka Y, Mitsuda N, Amino N 1996 Changes in soluble CD4 and CD8 proteins in healthy pregnant and postpartum women. Am J Reprod Immunol 36:220-7.
  11. Watanabe M, Iwatani Y, Kashiwai T, Iijima T, Fujikado T, Amino N 1995 Euthyroid Graves' disease showing no thyroid abnormalities except positive thyroid-stimulating antibody (TSAb): two case reports. J Intern Med 238:379-84.
  12. Watanabe K, Iwatani Y, Hidaka Y, Watanabe M, Amino N 1995 Long-term effects of thyroid hormone on lymphocyte subsets in spleens and thymuses of mice. Endocr J 42:661-8.
  13. Takashima S, Fukuda H, Tomiyama N, Fujita N, Iwatani Y, Nakamura H 1995 Hashimoto thyroiditis: correlation of MR imaging signal intensity with histopathologic findings and thyroid function test results. Radiology 197:213-9.
  14. Suehisa E, Toku M, Akita N, Fushimi R, Takano T, Tada H, Iwatani Y, Amino N 1995 Study on an antibody against F1F2 fragment of human factor V in a patient with Hashimoto's disease and bullous pemphigoid. Thromb Res 77:63-8.
  15. Kashiwai T, Tada H, Asahi K, Hidaka Y, Tamaki H, Iwatani Y, Amino N 1995 Significance of thyroid stimulating antibody and long term follow up in patients with euthyroid Graves' disease. Endocr J 42:405-12.
  16. Kabutomori O, Iwatani Y, Koh T, Amino N 1995 Platelet satellitism found by an abnormal leukocyte cytogram with an automated cell counter. Am J Hematol 49:261-3.
  17. Kabutomori O, Iwatani Y 1995 "Correct" platelet count in EDTA-dependent pseudothrombocytopenia. Eur J Haematol 55:67-8.
  18. Tada H, Hidaka Y, Tsuruta E, Kashiwai T, Tamaki H, Iwatani Y, Amino N 1994 Prevalence of postpartum onset of disease within patients with Graves' disease of child-bearing age. Endocr J 41:325-7.
  19. Kashiwai T, Tada H, Tamaki H, Hidaka Y, Ito E, Iwatani Y, Amino N 1994 Reducing effect of nadolol on serum levels of free thyroid hormones in hyperthyroidism. Endocr J 41:717-23.
  20. Kabutomori O, Iwatani Y, Koh T, Amino N 1994 Red cell distribution (RDW) in patients with erythrocytes containing Howell-Jolly bodies. Clin Lab Haematol 16:407-8.
  21. Hidaka Y, Tamaki H, Iwatani Y, Tada H, Mitsuda N, Amino N 1994 Prediction of post-partum Graves' thyrotoxicosis by measurement of thyroid stimulating antibody in early pregnancy. Clin Endocrinol (Oxf) 41:15-20.
  22. Nishiyama S, Takano T, Hidaka Y, Takada K, Iwatani Y, Amino N 1993 A case of postpartum hypopituitarism associated with empty sella: possible relation to postpartum autoimmune hypophysitis. Endocr J 40:431-8.
  23. Kabutomori O, Iwatani Y, Koh T, Fushimi R, Amino N 1993 Decrease in the density of IgG-Fc receptor III (CD16) on 'toxic' neutrophils. Acta Haematol 89:163-4.
  24. Iwatani Y, Hidaka Y, Matsuzuka F, Kuma K, Amino N 1993 Intrathyroidal lymphocyte subsets, including unusual CD4+ CD8+ cells and CD3loTCR alpha beta lo/-CD4-CD8- cells, in autoimmune thyroid disease. Clin Exp Immunol 93:430-6.
  25. Hidaka Y, Amino N, Iwatani Y, Itoh E, Matsunaga M, Tamaki H 1993 Recurrence of thyrotoxicosis after attack of allergic rhinitis in patients with Graves' disease. J Clin Endocrinol Metab 77:1667-70.
  26. Iwatani Y, Amino N, Hidaka Y, Kaneda T, Ichihara K, Tamaki H, Matsuzuka F, Fukata S, Kuma K, Miyai K 1992 Decreases in alpha beta T cell receptor negative T cells and CD8 cells, and an increase in CD4+ CD8+ cells in active Hashimoto's disease and subacute thyroiditis. Clin Exp Immunol 87:444-9.
  27. Hidaka Y, Amino N, Iwatani Y, Kaneda T, Nasu M, Mitsuda N, Tanizawa O, Miyai K 1992 Increase in peripheral natural killer cell activity in patients with autoimmune thyroid disease. Autoimmunity 11:239-46.
  28. Tamaki H, Amino N, Iwatani Y, Matsuzuka F, Kuma K, Miyai K 1991 Detection of thyroid microsomal and thyroglobulin antibodies by new sensitive radioimmunoassay in Hashimoto's disease; comparison with conventional hemagglutination assay. Endocrinol Jpn 38:97-101.
  29. Hidaka Y, Amino N, Iwatani Y, Kaneda T, Mitsuda N, Morimoto Y, Tanizawa O, Miyai K 1991 Changes in natural killer cell activity in normal pregnant and postpartum women: increases in the first trimester and postpartum period and decrease in late pregnancy. J Reprod Immunol 20:73-83.
  30. Sakatsume Y, Matsubayashi S, Kasuga Y, Iitaka M, Iwatani Y, Volpe R 1990 CD4 cells from patients with autoimmune thyroid disease secrete interferon gamma after stimulation by thyroid microsomal antigen; CD8 cells suppress this secretion. J Endocrinol Invest 13:717-26.
  31. Tamaki H, Amino N, Iwatani Y, Miyai K 1989 Improvement of infiltrative ophthalmopathy in parallel with decrease of thyroid-stimulating antibody (TSAb) activity in two patients with hypothyroid Graves' disease. J Endocrinol Invest 12:47-53.
  32. Tamaki H, Amino N, Iwatani Y, Tachi J, Kimura M, Mitsuda N, Ichihara K, Tanizawa O, Miyai K 1989 Evaluation of TSH receptor antibody by 'natural in vivo human assay' in neonates born to mothers with Graves' disease. Clin Endocrinol (Oxf) 30:493-503.
  33. Tamaki H, Amino N, Aozasa M, Mori M, Iwatani Y, Tachi J, Nose O, Tanizawa O, Miyai K 1989 Effective method for prediction of transient hypothyroidism in neonates born to mothers with chronic thyroiditis. Am J Perinatol 6:296-303.
  34. Tamaki H, Amino N, Iwatani Y, Tachi J, Mitsuda N, Tanizawa O, Miyai K 1989 Discordant changes in serum anti-TSH receptor antibody and antithyroid microsomal antibody during pregnancy in autoimmune thyroid diseases. Thyroidology 1:73-7.
  35. Tamaki H, Amino N, Takeoka K, Iwatani Y, Tachi J, Kimura M, Mitsuda N, Miki K, Nose O, Tanizawa O, et al. 1989 Prediction of later development of thyrotoxicosis or central hypothyroidism from the cord serum thyroid-stimulating hormone level in neonates born to mothers with Graves disease. J Pediatr 115:318-21.
  36. Tachi J, Amino N, Tamaki H, Takeoka K, Kimura M, Iwatani Y, Ichihara K, Miyai K 1989 Cellular immunity as a valuable factor for prognostic prediction in patients with Graves' disease under antithyroid drug therapy. Thyroidology 1:85-92.
  37. Iwatani Y, Amino N, Miyai K 1989 Peripheral self-tolerance and autoimmunity: the protective role of expression of class II major histocompatibility antigens on non-lymphoid cells. Biomed Pharmacother 43:593-605.
  38. Iwatani Y, Amino N, Miyai K 1989 Fail-safe mechanism against autoimmunity. Lancet 1:1141.
  39. Iwatani Y, Amino N, Kabutomori O, Kaneda T, Tanizawa O, Miyai K 1989 Peripheral large granular lymphocytes in normal pregnant and postpartum women: decrease in late pregnancy and dynamic change in the puerperium. J Reprod Immunol 16:165-72.
  40. Iwatani Y, Amino N, Kaneda T, Ichihara K, Tamaki H, Tachi J, Matsuzuka F, Fukata S, Kuma K, Miyai K 1989 Marked increase of CD5 + B cells in hyperthyroid Graves' disease. Clin Exp Immunol 78:196-200.
  41. Asari S, Iwatani Y, Amino N, Tanizawa O, Miyai K 1989 Peripheral K cells in normal human pregnancy: decrease during pregnancy and increase after delivery. J Reprod Immunol 15:31-7.
  42. Aozasa M, Amino N, Iwatani Y, Tamaki H, Matsuzuka F, Kuma K, Miyai K 1989 Intrathyroidal HLA-DR-positive lymphocytes in Hashimoto's disease: increases in CD8 and Leu7 cells. Clin Immunol Immunopathol 52:516-22.
  43. Tamaki H, Amino N, Aozasa M, Mori M, Iwatani Y, Tachi J, Nose O, Tanizawa O, Miyai K 1988 Universal predictive criteria for neonatal overt thyrotoxicosis requiring treatment. Am J Perinatol 5:152-8.
  44. Tachi J, Amino N, Tamaki H, Aozasa M, Iwatani Y, Miyai K 1988 Long term follow-up and HLA association in patients with postpartum hypothyroidism. J Clin Endocrinol Metab 66:480-4.
  45. Tachi J, Amino N, Iwatani Y, Tamaki H, Mori M, Aozasa M, Tanizawa O, Miyai K 1988 Increase in antideoxyribonucleic acid antibody titer in postpartum aggravation of autoimmune thyroid disease. J Clin Endocrinol Metab 67:1049-53.
  46. Iwatani Y, Amino N, Tamaki H, Aozasa M, Kabutomori O, Mori M, Tanizawa O, Miyai K 1988 Increase in peripheral large granular lymphocytes in postpartum autoimmune thyroiditis. Endocrinol Jpn 35:447-53.
  47. Iwatani Y, Iitaka M, Row VV, Volpe R 1988 Effect of HLA-DR positive thyrocytes on in vitro thyroid autoantibody production. Clin Invest Med 11:279-85.
  48. Iwatani Y, Amino N, Tachi J, Kimura M, Ura I, Mori M, Miyai K, Nasu M, Tanizawa O 1988 Changes of lymphocyte subsets in normal pregnant and postpartum women: postpartum increase in NK/K (Leu 7) cells. Am J Reprod Immunol Microbiol 18:52-5.
  49. Iwatani Y, Amino N, Kabutomori O, Tamaki H, Aozasa M, Motoi S, Miyai K 1988 Effects of different sample preparations on enumeration of large granular lymphocytes (LGLs), and demonstration of a sex difference of LGLs. Am J Clin Pathol 90:674-8.
  50. Iitaka M, Aguayo JF, Iwatani Y, Row VV, Volpe R 1988 Studies of the effect of suppressor T lymphocytes on the induction of antithyroid microsomal antibody-secreting cells in autoimmune thyroid disease. J Clin Endocrinol Metab 66:708-14.
  51. Iitaka M, Iwatani Y, Row VV, Volpe R 1988 Production of antigen specific procoagulant activity; effect of various culture supernatants. J Clin Lab Immunol 27:51-5.
  52. Iitaka M, Aguayo JF, Iwatani Y, Row VV, Volpe R 1988 In vitro induction of anti-thyroid microsomal antibody-secreting cells in peripheral blood mononuclear cells from normal subjects. J Clin Endocrinol Metab 67:749-54.
  53. Iwatani Y, Iitaka M, Gerstein HC, Row VV, Volpe R 1987 Separate induction of MHC and thyroid microsomal antigen (McAg) expression on thyroid cell monolayers: enhancement of lectin-induced McAg expression by interferon-gamma. J Clin Endocrinol Metab 64:1302-8.
  54. Iwatani Y, Amino N, Tanizawa O, Mori H, Kawashima M, Yabu Y, Miyai K 1987 Decrease of free thyroxin in serum of lactating women. Clin Chem 33:1217-9.
  55. Iwatani Y, Iitaka M, Row VV, Volpe R 1987 Induction of thyroid autoantibody production: synergistic effect of B cell mitogen combined with T cell mitogen. J Clin Endocrinol Metab 65:853-61.
  56. Iitaka M, Iwatani Y, Gerstein HC, Row VV, Volpe R 1987 Immunomodulatory effect of the treatment of Graves' disease on antigen-specific monocyte procoagulant activity production. Clin Endocrinol (Oxf) 27:321-30.
  57. Iitaka M, Iwatani Y, Row VV, Volpe R 1987 Induction of monocyte procoagulant activity with OKT3 antibody. J Immunol 139:1617-23.
  58. Gerstein HC, Rastogi B, Iwatani Y, Iitaka M, Row VV, Volpe R 1987 The decrease in non-specific suppressor T lymphocytes in female hyperthyroid Graves' disease is secondary to the hyperthyroidism. Clin Invest Med 10:337-44.
  59. Aozasa M, Amino N, Iwatani Y, Tamaki H, Tachi J, Fujiyasu S, Nasu M, Matsuzuka F, Kuma K, Miyai K 1987 Separation and analysis of mononuclear cells infiltrating the thyroid of patients with Graves' disease. Clin Immunol Immunopathol 43:343-53.
  60. Amino N, Watanabe Y, Tamaki H, Iwatani Y, Miyai K 1987 In-vitro conversion of blocking type anti-TSH receptor antibody to the stimulating type by anti-human IgG antibodies. Clin Endocrinol (Oxf) 27:615-24.
  61. Iwatani Y, Gerstein HC, Iitaka M, Row VV, Volpe R 1986 Thyrocyte HLA-DR expression and interferon-gamma production in autoimmune thyroid disease. J Clin Endocrinol Metab 63:695-708.
  62. Iitaka M, Bernstein J, Gerstein HC, Iwatani Y, Row VV, Volpe R 1986 Sensitization of T lymphocytes to thyroid antigen in autoimmune thyroid disease as demonstrated by the monocyte procoagulant activity test. J Endocrinol Invest 9:471-8.
  63. Watanabe Y, Amino N, Tamaki H, Iwatani Y, Miyai K 1985 Bovine thyrotropin inhibits DNA synthesis inversely with stimulation of cyclic AMP production in cultured porcine thyroid follicles. Endocrinol Jpn 32:81-8.
  64. Iwatani Y, Row VV, Volpe R 1985 What prevents autoimmunity? Lancet 2:839-40.
  65. Aozasa M, Amino N, Iwatani Y, Tamaki H, Watanabe Y, Sato H, Hochito K, Umeda K, Gunji T, Yoshizawa T, et al. 1985 Familial OKT4 epitope deficiency: studies on antigen density and lymphocyte function. Clin Immunol Immunopathol 37:48-55.
  66. Tamaki H, Amino N, Iwatani Y, Kawashima M, Nishimura H, Kitaura T, Matsuzuka F, Kuma K, Kumahara Y, Miyai K 1984 Relation of structural polarity to responses of cyclic 3', 5'-adenosine monophosphate accumulation and thyroid hormone release in cultured human thyroid follicles. Endocrinol Jpn 31:99-108.
  67. Iwatani Y, Amino N, Kabutomori O, Mori H, Tamaki H, Motoi S, Izumiguchi Y, Miyai K 1984 Decrease of peripheral large granular lymphocytes in Graves' disease. Clin Exp Immunol 55:239-44.
  68. Amino N, Aozasa M, Iwatani Y, Tamaki H, Miyai K, Sato H, Gunji T 1984 Familial OKT4+ lymphocyte deficiency. Lancet 2:94-5.
  69. Mori H, Amino N, Iwatani Y, Asari S, Miyai K 1983 Correlation of peripheral T gamma and K lymphocytes in normal subjects and patients with autoimmune thyroid diseases. J Clin Lab Immunol 12:119-22.
  70. Iwatani Y, Amino N, Mori H, Asari S, Izumiguchi Y, Kumahara Y, Miyai K 1983 T lymphocyte subsets in autoimmune thyroid diseases and subacute thyroiditis detected with monoclonal antibodies. J Clin Endocrinol Metab 56:251-4.
  71. Mori H, Amino N, Iwatani Y, Asari S, Izumiguchi Y, Kumahara Y, Miyai K 1982 Decrease of immunoglobulin G-Fc receptor-bearing T lymphocytes in Graves' disease. J Clin Endocrinol Metab 55:399-402.
  72. Iwatani Y, Amino N, Mori H, Asari S, Matsuzuka F, Kuma K, Miyai K 1982 A microcytotoxicity assay for thyroid-specific cytotoxic antibody, antibody-dependent cell-mediated cytotoxicity and direct lymphocyte cytotoxicity using human thyroid cells. J Immunol Methods 48:241-50.
  73. Iwatani Y, Amino N, Mori H, Asari S, Ina K, Ennyu K, Miyai K 1982 Effects of various isolation methods for human peripheral lymphocytes on T cell subsets determined in a fluorescence activated cell sorter (FACS), and demonstration of a sex difference of suppressor/cytotoxic T cells. J Immunol Methods 54:31-42.
  74. Amino N, Mori H, Iwatani Y, Asari S, Izumiguchi Y, Miyai K 1982 Peripheral K lymphocytes in autoimmune thyroid disease: decrease in Graves' disease and increase in Hashimoto's disease. J Clin Endocrinol Metab 54:587-91.
  75. Amino N, Mori H, Iwatani Y, Tanizawa O, Kawashima M, Tsuge I, Ibaragi K, Kumahara Y, Miyai K 1982 High prevalence of transient post-partum thyrotoxicosis and hypothyroidism. N Engl J Med 306:849-52.
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