Original Articles / 原著論文・著書・総説等

［英文原著・総説］・「邦文原著・総説］・［報道関係］・［知的財産権］
［受賞］・［国際学会発表］・［国内学会発表］


English publications/英文原著・総説等

  1. Hirai, N., Watanabe, M., Inoue, N., Kishonita, R., Ohtani, H., Hidaka, Y,. Iwatani, Y.: Association of IL6 gene methylation in peripheral blood cells with the development and prognosis of autoimmune thyroid diseases. Autoimmunity (in press)
  2. Yamamoto, M., Watanabe, M., Inoue, N., Watanabe, A., Ozaki, H., Ohsaki, M., Yidaka, Y., Iwatani, Y.: Association of CD58 polymorphisms and its protein expression with the development and prognosis of autoimmune thyroid diseases. Immunological Investigations (in press)
  3. Hashimoto, H. Watanabe, M., Inoue, N., Hirai, N., Haga, E., Kinoshita, R., Hidaka, Y., Iwatani, Y.: Association of IFNG gene methylation in peripheral blood cells with the development and prognosis of autoimmune thyroid disease. Cytokine (in press) . doi: 10.1016/j.cyto.2019.154770
  4. Fukano, H., Takano, T., Fujimoto, Y., Nakatani, R., Watanabe, M., Hidaka, Y., Shimomura, I.: In tube immunocytochemistry for fluorescence-activated cell sorting that prevents RNA degradation in sorted cells. Biotechnic & Histochemistry (published online: 19 Aug 2019) . doi: 10.1080/10520295.2019.1632485
  5. Honda, C., Watanabe, M., Tomizawa, R., Osaka Twin Research Group, Sakai, N.: Update on Osaka University Twin Registry: An Overview of Multidisciplinary Research Resources and Biobank at Osaka University Center for Twin Research. Twin Res Hum Genet, (in press)
  6. Silventoinen K, Jelenkovic A, Yokoyama Y, Sund R, Sugawara M, Tanaka M,Matsumoto S, Bogl LH, Freitas DL, Maia JA, Hjelmborg JVB, Aaltonen S, Piirtola M, Latvala A, Calais-Ferreira L, Oliveira VC, Ferreira PH, Ji F, Ning F, Pang Z, Ordoñana JR, Sánchez-Romera JF, Colodro-Conde L, Burt SA, Klump KL, Martin NG, Medland SE, Montgomery GW, Kandler C, McAdams TA, Eley TC, Gregory AM, Saudino KJ, Dubois L, Boivin M, Brendgen M, Dionne G, Vitaro F, Tarnoki AD, Tarnoki DL, Haworth CMA, Plomin R, Öncel SY, Aliev F, Medda E, Nisticò L, Toccaceli V, Craig JM, Saffery R, Siribaddana SH, Hotopf M, Sumathipala A, Rijsdijk F, Jeong HU, Spector T, Mangino M, Lachance G, Gatz M, Butler DA, Gao W, Yu C, Li L,Bayasgalan G, Narandalai D, Harden KP, Tucker-Drob EM, Christensen K,Skytthe A, Kyvik KO, Derom CA, Vlietinck RF, Loos RJF, Cozen W, Hwang AE, Mack TM, He M, Ding X, Silberg JL, Maes HH, Cutler TL, Hopper JL,Magnusson PKE, Pedersen NL, Dahl Aslan AK, Baker LA, Tuvblad C,Bjerregaard-Andersen M, Beck-Nielsen H, Sodemann M, Ullemar V, Almqvist C, Tan Q, Zhang D, Swan GE, Krasnow R, Jang KL, Knafo-Noam A, Mankuta D,Abramson L, Lichtenstein P, Krueger RF, McGue M, Pahlen S, Tynelius P,Rasmussen F, Duncan GE, Buchwald D, Corley RP, Huibregtse BM, Nelson TL, Whitfield KE, Franz CE, Kremen WS, Lyons MJ, Ooki S, Brandt I, Nilsen TS, Harris JR, Sung J, Park HA, Lee J, Lee SJ, Willemsen G, Bartels M, van Beijsterveldt CEM, Llewellyn CH, Fisher A, Rebato E, Busjahn A, Tomizawa R, Inui F, Watanabe M, Honda C, Sakai N, Hur YM, Sørensen TIA, Boomsma DI, Kaprio J.: The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins. Twin Res Hum Genet, (in press) . doi: 10.1017/thg.2019.35.
  7. Kunisato, T. , Watanabe, M., Inoue, N., Okada, A., Nanba, T., Kobayashi, W., Inoue, Y., Katsumata, Y., Omori, N., Nobuhara, T., Takemura, K., Hidaka, Y., Iwatani, Y: Polymorphisms in Th17-related genes and the pathogenesis of autoimmune thyroid disease. Autoimmunity , 2018. doi: 10.1080/08916934.2018.1534963
  8. Piirtola, N., Jelenkovic, A., Latvala, A., Sund. R., Honda, C., Inui, F., Watanabe, M., Tomizawa, R., Iwatani, Y., Ordoñana, J.R., Sánchez-Romera, J.F., Colodro-Conde, L., Tarnoki, A.D., Tarnoki, D.L., Martin, N.G., Montgomery, G.W., Medland, S.E., Rasmussen, F., Tynelius, P., Tan, Q., Zhang, D., Pang, Z., Rebato, E., Stazi, M.A., Fagnani, C., Brescianini, S., Busjahn, A., Harris. J.R., Brandt, I., Nilsen, T.S., Cutler, T.L., Hopper, J.L., Corley, R.P., Huibregtse, B.M., Sung, J., Kim, J., Lee, J., Lee, S., Gatz, M., Butler, D.A., Franz, C.E., Kremen, W.S., Lyons, M.J., Magnusson, P.K.E., Pedersen, N.L., Aslan, A.K.D., Y Öncel, S., Aliev, F., Derom, C.A., Vlietinck, R.F., Loos, R.J.F., Silberg, J.L., Maes, H.H., Boomsma, D.I., Sørensen, T.I.A., Korhonen, T., Kaprio, J., Silventoinen, K.: Association of current and former smoking with body mass index: a study of smoking discordant twin pairs from 21 twin cohorts. PLOS ONE, 13(7), e020014, 2018. doi: 10.1371/journal.pone.0200140.
  9. Omori, N., Watanabe, M., Inoue, N., Taniguchi, J., Hidaka, Y., Iwatani, Y.: Association of the polymorphisms in Th2 chemotaxis-related genes with the development and prognosis of autoimmune thyroid diseases. Endocrine J 65(8), 815-826, 2018. doi: 10.1507/endocrj.EJ18-0050.
  10. Inoue, N., Watanabe, M., Katsumata, Y., Ishido, N., Hidaka, Y., Iwatani, Y.: Functional polymorphisms of the type 1 and type 2 iodothyronine deiodinase genes in autoimmune thyroid diseases. Immunol Invest, 47(5), 534-542, 2018, doi: 10.1080/08820139.2018.1458861.
  11. Masutani, R., Ikemoto, T., Maki, A., Tanada, H., Iwatani, Y., Watanabe, M., Takubo, T., Okada, Y.: Mean platelet component and mean platelet volume are the useful screening markers of myelodysplastic syndrome. Health Science Reports, 1(5), e50, 2018, doi: 10.1002/hsr2.50
  12. Morita, E., Watanabe, M., Inoue, N., Hashimoto, H., Haga, E., Hidaka, Y., Iwatani, Y.: Methylation levels of the TNFA gene are different between Graves’ and Hashimoto’s diseases and influenced by the TNFA polymorphism. Autoimmunity, 51(3), 118-125, 2018, doi: 10.1080/08916934.2018.1448078.
  13. Tokiyoshi, E., Watanabe, M., Inoue, N., Hidaka, Y., Iwatani, Y: Polymorphisms and expression of genes encoding ARGONAUTES 1 and 2 in autoimmune thyroid diseases . Autoimmunity 51(1), 35-42, 2018, doi: 10.1080/08916934.2017.1416468.
  14. Watanabe, M., Takenaka, Y., Honda, C., Osaka Twin Research Group, Iwatani, Y.: Genotype-based epigenetic differences in monozygotic twins discordant for positive anti-thyroglobulin autoantibodies. Thyroid　28(1): 110-123, 2018, doi:10.1089/thy.2017.0273.
  15. Araki, T., Onishi, M., Yanagisawa, T., Hirata, M., Watanabe, Y., Ogata, S., Hayakawa, K., Honda, C., Watanabe, M., Iwatani, Y., Yorifuji, S.: Frequency-specific genetic influence on inferior parietal lobule activation commonly observed during action observation and execution. Scientific Reports 15;7(1):17660, 2017
  16. Watanabe, M.: Thyroid hormone and autoimmune diseases. In: Akamizu, T., Yamada, M., Yoshimura, H. eds. Thyroid hormone and their related diseases. an extended edition of Journal of the Japan Thyroid Association, 8(2), 161-169, 2017
  17. Suetake, I., Watanabe, M., Takeshita, K., Takahashi, S., Carlton, P.: The molecular basis of DNA methylation. In: DNA and Histone Methylation as Cancer Targets (Cancer Drug Discovery and Development), 19-51, 2017, Humana Press (ISBN-10: 3319597841)
  18. Tomari, S., Watanabe, M., Inoue, N., Mizuma, T., Yamanaka, C., Hidaka, Y., Iwatani, Y.: The polymorphisms in the thyroid peroxidase gene were associated with the development of autoimmune thyroid disease and the serum levels of TPOAb. Endocrine J, 64(10), 1025-1032, 2017 doi: 10.1507/endocrj.EJ17-0191.
  19. Mishima, Y., Brueckner, L., Takahashi, S., Kawakami, T., Arita, K., Oka, S., Otani, J., Hojo, H., Shirakawa, M., Shinohara, A., Watanabe, M., Suetake, I.: RFTS-dependent negative regulation of Dnmt1 by nucleosome structure and histone tails. The FEBS Journal, 284(20), 3455-3469, 2017. doi: 10.1111/febs.14205.
  20. Silventoinen, K. Jelenkovic, A., Latvala, A., Sund, R., Yokoyama, Y., Ullemar, V., Almqvist, C., Derom, C.A., Vlietinck, R.F., Loos, R.JF., Kandler, C., Honda, C., Inui, F., Iwatani, Y., Watanabe, M., Rebato, E., Stazi, M.A., Fagnani, C., Brescianini, S., Hur, Y., Jeong, H., Cutler, T.L., Hopper, J.L., Busjahn, A., Saudino, K.J., Ji, G., Ning, F., Pang, Z., Rose, R.J., Koskenvuo, M., Heikkilä, K., Cozen, W., Hwang, A.E., Mack, T.M., Siribaddana, S.H., Hotopf, M., Sumathipala, A., Rijsdijk, F., Sung, J., Kim, J., Lee, J., Lee, S., Nelson, T.L., Whitfield, K.E., Tan, Q., Zhang, D., Llewellyn, C.H., Fisher, A., Burt, S.A., Klump, K.L., Knafo-Noam, A., Mankuta, D., Abramson, L., Medland, S.E., Martin, N.G., Montgomery, G.W., Magnusson, P.KE., Pedersen, N.L., Aslan, A.K.D., Corley, R.P., Huibregtse, M.M., Öncel, S.Y., Aliev, F., Krueger, R.F., McGue, M., Pahlen, S., Willemsen, G., Bartels, M., van Beijsterveldt, C.EM., Silberg, J.L., Eaves, L.J., Maes, H.H., Harris, J.R., Brandt, I., Nilsen, T.S., Rasmussen, F., Tynelius, P., Baker, L.A., Tuvblad, C., Ordoñana, J.R., Sánchez-Romera, J.F., Colodro-Conde, L., Gatz, M., Butler, D.A., Lichtenstein, P., Goldberg, J.H., Harden, K.P., Tucker-Drob, E.M., Duncan, G.E., Buchwald, D., Tarnoki, A.D., Tarnoki, D.L., Franz, C.E., Kremen, W.S., Lyons, M.J., Maia, J.A., Freitas, D.L>, Turkheimer, E., Sørensen, T.IA., Boomsma, D.I., Kaprio, J.: Education in twins and their parents across birth cohorts over 100 years: an individual-level pooled analysis of 42 twin cohorts. Twin Res Hum Genet, 20(5):395-405, 2017. doi: 10.1017/thg.2017.49.
  21. Takuse, Y., Watanabe, M., Inoue, N., Ozaki, R., Otsu, H., Saeki, M., Katsumata, Y., Hidaka, Y., Iwatani, Y.: Association of IL-10-Regulating MicroRNAs in Peripheral Blood Mononuclear Cells with the Pathogenesis of Autoimmune Thyroid Disease. Immunological Investigation, 46(6), 590-602, 2017. doi: 10.1080/08820139.2017.1322975.
  22. Silventoinen K, Jelenkovic A, Sund R, Yokoyama Y, Hur YM, Cozen W, Hwang AE, Mack TM, Honda C, Inui F, Iwatani Y, Watanabe M, Tomizawa R, Pietiläinen KH, Rissanen A, Siribaddana SH, Hotopf M, Sumathipala A, Rijsdijk F, Tan Q, Zhang D, Pang Z, Piirtola M, Aaltonen S, Öncel SY, Aliev F, Rebato E, Hjelmborg JB, Christensen K, Skytthe A, Kyvik KO, Silberg JL, Eaves LJ, Cutler TL, Ordoñana JR, Sánchez-Romera JF, Colodro-Conde L, Song YM, Yang S, Lee K, Franz CE, Kremen WS, Lyons MJ, Busjahn A, Nelson TL, Whitfield KE, Kandler C, Jang KL, Gatz M, Butler DA, Stazi MA, Fagnani C, D'Ippolito C, Duncan GE, Buchwald D, Martin NG, Medland SE, Montgomery GW, Jeong HU, Swan GE, Krasnow R, Magnusson PK, Pedersen NL, Dahl Aslan AK, McAdams TA, Eley TC, Gregory AM, Tynelius P, Baker LA, Tuvblad C, Bayasgalan G, Narandalai D, Spector TD, Mangino M, Lachance G, Burt SA, Klump KL, Harris JR, Brandt I, Nilsen TS, Krueger RF, McGue M, Pahlen S, Corley RP, Huibregtse BM, Bartels M, van Beijsterveldt CE, Willemsen G, Goldberg JH, Rasmussen F, Tarnoki AD, Tarnoki DL, Derom CA, Vlietinck RF, Loos RJ, Hopper JL, Sung J, Maes HH, Turkheimer E, Boomsma DI, Sørensen TI, Kaprio J.: Differences in genetic and environmental variation in adult body mass index by sex, age, time period, and region: an individual-based pooled analysis of 40 twin cohorts. Am J Clin Nutr. 2017 Jul 5. pii: ajcn153643. doi: 10.3945/ajcn.117.153643.
  23. Mizuma, T., Watanabe, M., Inoue, N., Arakawa, Y., Tomari, S., Hidaka, Y., Iwatani, Y.: Association of the polymorphisms in the gene encoding thyroglobulin with the development and prognosis of autoimmune thyroid disease. Autoimmunity 4:1-7, 2017. doi: 10.1080/08916934.2017.1344971.
  24. Inoue, N., Watanabe, M, Nakaguchi, A., ,Ueda, A., Kawaguchi, H., Hidaka, Y., Iwatani, Y.:Functional polymorphisms affecting Th1 differentiation are associated with the severity of autoimmune thyroid diseases. Endocrine J, 64(7), 695-703. doi: 10.1507/endocrj.EJ16-0551.
  25. Wang, T., Jeong, H., Watanabe, M., Iwatani, Y., Ohno, Y.: Fault classification with discriminant analysis during sit-to-stand movement assisted by a nursing care robot. Mechanical Systems and Signal Processing (in press)
  26. Arakawa, Y. Watanabe, M., Takemura, K., Inoue, N., Hidaka, Y., Iwatani, Y.: The IL15 +96522 A>T functional polymorphism is related to the differentiation of Th17 cells and the severity of Hashimoto’s disease. International Journal of Immunogenetics 44(2), 41-50, 2017. doi: 10.1111/iji.12305.
  27. Otsu, H., Watanabe, M., Inoue, N., Masutani, R., Iwatani, Y.: Intraindividual variation of microRNA expression levels in plasma and peripheral blood mononuclear cells and the associations of these levels with the pathogenesis of autoimmune thyroid diseases. Clin Chem Lab Med 55(5), 626-635, 2017. doi: 10.1515/cclm-2016-0449.
  28. Inoue, N., Katsumata, Y., Watanabe, M., Ishido, N., Manabe, Y., Watanabe, A., Masutani, R., Hidaka, Y., Iwatani, Y.: Polymorphisms in and expression of Toll-like receptors in autoimmune thyroid diseases. Autoimmunity , 50(3), 182-191, 2017. doi: 10.1080/08916934.2016.1261835.
  29. Fujii, A., Inoue, N., Watanabe, M., Kawakami, C., Hidaka, Y., Hayashizaki, Y. and Iwatani, Y.: TSHR gene polymorphisms in the enhancer regions are most strongly associated with the development of Graves’ disease, especially intractable disease, and with that of Hashimoto’s disease. Thyroid 27(1), 111-119, 2017. doi: 10.1089/thy.2016.0345.
  30. Maeda, T., Date, A., Watanabe, M., Hidaka, Y., Iwatani, Y., Takano, T.: Optimization of recovery and analysis of RNA in sorted cells in mRNA quantification after fluorescence-activated cell sorting. Ann Clin Lab Sci, 46(6), 435-441, 2016
  31. Jelenkovic, A., Hur, Y., Sund, R., Yokoyama, Y., Siribaddana, S., Hotopf, M., Sumathipala, A., Rijsdijk, F., Tan, Q., Zhang, D., Pang, A., Aaltonen, S., Heikkilä, K., Öncel, S., Aliev, F., Rebato, E., Tarnoki, A., Tarnoki, D., Christensen, K., Skytthe, A., Kyvik, K., Silberg, J., Eaves, L., Maes, H., Cutler, T., Hopper, J., Ordoñana, J., Sánchez-Romera, J., Colodro-Conde, L., Cozen, W., Hwang, A., Mack, T., Sung, J., Song, Y., Yang, S., Lee, K., Franz, C., Kremen, W., Lyons, M., Busjahn, A., Nelson, T., Whitfield, K., Kandler, C., Jang, K., Gatz, M., Butler, D., Stazi, M., Fagnani, C., D'Ippolito, C., Duncan, G., Buchwald, D., Derom, C., Vlietinck, R., Loos, R., Martin, N., Medland, S., Montgomery, G., Jeong, H., Swan, G., Krasnow, R., Magnusson, P., Pedersen, N., Aslan, A., McAdams, T., Eley, T., Gregory, A., Tynelius, P., Baker, L., Tuvblad, C., Bayasgalan, G., Narandalai, D., Lichtenstein, P., Spector, T., Mangino, M., Lachance, G., Bartels, M., Beijsterveldt, T., Willemsen, G., Burt, S., Klump, K., Harris, J., Brandt, I., Nilsen, T., Krueger, R., McGue, M., Pahlen, S., Corley, R., Hjelmborg, J., Goldberg, J., Iwatani, Y., Watanabe, M., Honda, C., Inui, F., Rasmussen, F., Huibregtse, B., Boomsma, D., Sørensen, T., Kaprio, J., Silventoinen, K. : Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994, eLife, 5, 2016. pii: e20320. doi: 10.7554/eLife.20320.
  32. Watanabe, M., Honda, C., The Osaka Twin Research Group, Iwatani, Y.: Within-pair differences of DNA methylation levels between monozygotic twins are different between male and female pairs. BMC Medical Genomics, 9, 55-63, 2016. DOI: 10.1186/s12920-016-0217-2
  33. Saeki, M., Watanabe, M., Inoue, N., Tokiyoshi, E. Takuse, Y., Arakawa, Y. Hidaka, Y., Iwatani, Y.: DICER and DROSHA gene expression and polymorphisms in autoimmune thyroid diseases . Autoimmunity 9(8), 514-522, 2016
  34. Inoue, N., Watanabe, M., Ishido, N., Kodu, A., Maruoka, H., Katsumata, Y., Hidaka, Y., Iwatani, Y.: Involvement of genes encoding apoptosis regulatory factors (FAS, FASL, TRAIL, BCL2, TNFR1 and TNFR2) in the pathogenesis of autoimmune thyroid diseases. Hum Immunol , 77(10), 944-5, 2016
  35. Kagawa, T., Watanabe, M., Inoue, N., Otsu, H., Saeki, M., Katsumata, Y., Takuse, Y., Iwatani, Y.: Increases of microRNA let-7e in peripheral blood mononuclear cells in Hashimoto’s disease. Endocrin J , 63(4), 375-80, 2016
  36. Sarumaru, M., Watanabe, M., Inoue, N., Hisamoto, Y., Morita, E., Arakawa, Y., Hidaka, Y., Iwatani, Y.:Association between functional SIRT1 polymorphisms and the clinical　characteristics of patients with autoimmune thyroid disease. Autoimmunity, 31:1-9, 2016
  37. Akahane, M., Watanabe, M., Inoue, N., Miyahara, Y., Arakawa, Y., Inoue, Y., Katsumata, Y., Hidaka, Y., Iwatani, Y.: Association of the polymorphisms of chemokine genes (IL8, RANTES, MIG, IP10, MCP1 and IL16) with the pathogenesis of autoimmune thyroid diseases . Autoimmunity 31, 1-8, 2016
  38. Yoshie, N., Watanabe, M., Inoue, N., Kawaguchi, H., Hidaka, Y., Iwatani, Y.: Association of polymorphisms in the ICOS and ICOSL genes with the pathogenesis of autoimmune thyroid diseases. Endocrin J, 63(1), :61-8, 2016
  39. Jelenkovic A, Yokoyama Y, Sund R, Honda C, Bogl LH, Aaltonen S, Ji F, Ning F, Pang Z, Ordoñana JR, Sánchez-Romera JF, Colodro-Conde L, Burt SA, Klump KL, Medland SE, Montgomery GW, Kandler C, McAdams TA, Eley TC, Gregory AM, Saudino KJ, Dubois L, Boivin M, Tarnoki AD, Tarnoki DL, Haworth CM, Plomin R, Öncel SY, Aliev F, Stazi MA, Fagnani C, D'Ippolito C, Craig JM, Saffery R, Siribaddana SH, Hotopf M, Sumathipala A, Rijsdijk F, Spector T, Mangino M, Lachance G, Gatz M, Butler DA, Bayasgalan G, Narandalai D, Freitas DL, Maia JA, Harden KP, Tucker-Drob EM, Kim B, Chong Y, Hong C, Shin HJ, Christensen K, Skytthe A, Kyvik KO, Derom CA, Vlietinck RF, Loos RJ, Cozen W, Hwang AE, Mack TM, He M, Ding X, Chang B, Silberg JL, Eaves LJ, Maes HH, Cutler TL, Hopper JL, Aujard K, Magnusson PK, Pedersen NL, Aslan AK, Song YM, Yang S, Lee K, Baker LA, Tuvblad C, Bjerregaard-Andersen M, Beck-Nielsen H, Sodemann M, Heikkilä K, Tan Q, Zhang D, Swan GE, Krasnow R, Jang KL, Knafo-Noam A, Mankuta D, Abramson L, Lichtenstein P, Krueger RF, McGue M, Pahlen S, Tynelius P, Duncan GE, Buchwald D, Corley RP, Huibregtse BM, Nelson TL, Whitfield KE, Franz CE, Kremen WS, Lyons MJ, Ooki S, Brandt I, Nilsen TS, Inui F, Watanabe M, Bartels M, van Beijsterveldt TC, Wardle J, Llewellyn CH, Fisher A, Rebato E, Martin NG, Iwatani Y, Hayakawa K, Sung J, Harris JR, Willemsen G, Busjahn A, Goldberg JH, Rasmussen F, Hur YM, Boomsma DI, Sørensen TI, Kaprio J, Silventoinen K.: Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age: A Study of the CODATwins Project. Twin Res Hum Genet. 557-70, 2015. [doi: 10.1017/thg.2015.57.]
  40. Silventoinen K, Jelenkovic A, Sund R, Honda C, Aaltonen S, Yokoyama Y, Tarnoki AD, Tarnoki DL, Ning F, Ji F, Pang Z, Ordoñana JR, Sánchez-Romera JF, Colodro-Conde L, Burt SA, Klump KL, Medland SE, Montgomery GW, Kandler C, McAdams TA, Eley TC, Gregory AM, Saudino KJ, Dubois L, Boivin M, Haworth CM, Plomin R, Öncel SY, Aliev F, Stazi MA, Fagnani C, D'Ippolito C, Craig JM, Saffery R, Siribaddana SH, Hotopf M, Sumathipala A, Spector T, Mangino M, Lachance G, Gatz M, Butler DA, Bayasgalan G, Narandalai D, Freitas DL, Maia JA, Harden KP, Tucker-Drob EM, Christensen K, Skytthe A, Kyvik KO, Hong C, Chong Y, Derom CA, Vlietinck RF, Loos RJ, Cozen W, Hwang AE, Mack TM, He M, Ding X, Chang B, Silberg JL, Eaves LJ, Maes HH, Cutler TL, Hopper JL, Aujard K, Magnusson PK, Pedersen NL, Aslan AK, Song YM, Yang S, Lee K, Baker LA, Tuvblad C, Bjerregaard-Andersen M, Beck-Nielsen H, Sodemann M, Heikkilä K, Tan Q, Zhang D, Swan GE, Krasnow R, Jang KL, Knafo-Noam A, Mankuta D, Abramson L, Lichtenstein P, Krueger RF, McGue M, Pahlen S, Tynelius P, Duncan GE, Buchwald D, Corley RP, Huibregtse BM, Nelson TL, Whitfield KE, Franz CE, Kremen WS, Lyons MJ, Ooki S, Brandt I, Nilsen TS, Inui F, Watanabe M, Bartels M, van Beijsterveldt TC, Wardle J, Llewellyn CH, Fisher A, Rebato E, Martin NG, Iwatani Y, Hayakawa K, Rasmussen F, Sung J, Harris JR, Willemsen G, Busjahn A, Goldberg JH, Boomsma DI, Hur YM, Sørensen TI, Kaprio J.: The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits. Twin Res Hum Genet. 27, 1-13, 2015. [doi: 10.1017/thg.2015.29.]
  41. Inoue, N., Watanabe, M., Katsumata, Y., Ishido, N., Hidaka, Y., Iwatani, Y.: Association between functional polymorphisms in the Toll-like receptor 4 (TLR4) gene and HD severity. Tissue Antigens 85(3), 209-11, 2015 [doi: 10.1111/tan.12518]
  42. Ishido,N., Inoue, N., Watanabe, M., Hidaka, Y., Iwatani, Y.: The Relationship between Skewed X Chromosome Inactivation and the Prognosis of Graves’ and Hashimoto’s Diseases，Thyroid , 25(2), 256-61, 2015. [doi: 10.1089/thy.2014.0318]
  43. Shimasue, A., Yamakawa, N., Watanabe, M., Hidaka, Y., Iwatani, Y., Takano, T.: Expression Analysis of Stemness Genes in a Rat Thyroid Cell Line FRTL5. Exp Clin Endocrinol Diabetes, 123(1), 48-54, 2015. [doi: 10.1055/s-0034-1389924]
  44. Inoue, N., Watanabe, M., Ishido, N., Katsumata, Y., Kagawa, T., Hidaka, Y., Iwatani, Y.:The functional polymorphisms of VDR, GC and CYP2R1 are involved in the pathogenesis of autoimmune thyroid diseases. Clin Exp Immunol 178(2), 262-269, 2014
  45. Inoue, Y., Watanabe, M., Inoue, N., Kagawa, T., Shibutani, S., Otsu, H., Saeki, M., Takuse, Y., Hidaka, Y., Iwatani, Y.: Associations of single nucleotide polymorphisms in pri-miR-125a and the expression of mature miR-125a with the development and prognosis of autoimmune thyroid diseases. Clin Exp Immunol 178(2) 229-235
  46. Date A., Maeda T., Watanabe M., Hidaka Y., Iwatani Y., Takano T.: An improved protocol for mRNA quantification after fluorescence-activated cell sorting with an increased signal to noise ratio in flow cytometry. Mol Biotechnol. 56(7), 591-8, 2014 [doi: 10.1007/s12033-014-9733-5]
  47. Inoue, N. Watanabe, M., Nobuhara, T., Hidaka, Y., Iwatani, Y.:The GG genotype of the 1125G/T polymorphism in the EPO gene protects against the development of Graves' disease. Immunol Letters, 156(1-2), 156-8, 2013 [doi: 10.1016/j.imlet.2013.10.006]
  48. Inoue, N., Watanabe, M., Katsumata, Y., Hidaka, Y., Iwatani, Y: Different genotypes of a functional polymorphism of the TSHR gene are associated with the development and severity of Graves and Hashimotos diseases. Tissue Antigen, 82(4), 288-90, 2013 [doi: 10.1111/tan.12190]
  49. Inoue, N., Watanabe, M., Wada, M., Morita, M., Hidaka, Y., Iwatani, Y. IL-10 -592A/C polymorphism is associated with severity of Hashimoto's disease. Cytokine , 64(1), 370-4, 2013 [doi: 10.1016/j.cyto.2013.05.014]
  50. Matsumoto, C., Ito, M., Yamada, H., Yoshida, H., Watanabe, M., Hidaka, Y., Iwatani, Y., Miyauchi, A., Takano, T: Preparation of thyroid follicular cells for mRNA quantifi cation after fl uorescence-activated cell sorting. Scandinavian Journal of Clinical & Laboratory Investigation, 73, 245–252, 2013 [doi: 10.3109/00365513.2013.769624]
  51. Inoue, N., Watanabe, M., Hayashi F., Hidaka, Y., Iwatani, Y.: The association between a functional polymorphism in the CD24 gene and the development of autoimmune thyroid diseases. Tissue Antigen, 81(3), 161-3, 2013 [doi: 10.1111/tan.12070]
  52. Matsumoto, C., Ito, M., Yamada, H., Yamakawa, N., Yoshida, H., Date, A., Watanabe, M., Hidaka, Y., Iwatani, Y., Miyauchi, A., Takano, T.: Genes that characterize T3-predominant Graves' thyroid tissues. Eur J Endocrinol, 168(2), 137-44, 2013 [doi: 10.1530/EJE-12-0507]
  53. Nagase, S., Kohguchi, K., Tohyama, K., Watanabe, M., Iwatani, Y.: Interference by Pralidoxime (PAM) salts in clinical laboratory tests. Clin Chim Acta, 416:72-79, 2013 [doi: 10.1016/j.cca.2012.11.017]
  54. Arakawa,Y., Watanabe, M., Inoue, N., Sarumaru, M., Hidaka, Y., Iwatani, Y.: Association ofpolymorphisms in DNMT1, DNMT3A, DNMT3B, MTHFR, and MTRR genes with global DNA methylation levels and prognosis of autoimmune thyroid disease. Clin Exp Immunol, 70(2), 194-201, 2012 [doi: 10.1111/j.1365-2249.2012.04646.x]
  55. Inoue, N. Watanabe, M., Yamada, H., Takemura, K., Hayashi, F., Yamakawa, N., Akahane, M., Shimizuishi, Y., Hidaka, Y., Iwatani, Y.: Associations between autoimmune thyroid disease prognosis and functional polymorphisms of susceptibility genes, CTLA4, PTPN22, CD40, FCRL3, and ZFAT, previously revealed in Genome-wide association studies. J Clin Immunol, 32(6), 1243-52, 2012 [doi: 10.1007/s10875-012-9721-0]
  56. Yamada, H., Takano, T., Kihara, M., Hirokawa, M., Yoshida, H., Watanabe, M., Iwatani, Y., Hidaka, Y., Miyauchi, A.: Masurement of TFF3 mRNA in aspirates from thyroid nodules using mesh filtration: The first clinical trial in 130 cases. Endocrine J 2012 Apr 26 online. [doi:10.1507/endocrj.EJ12-0077]
  57. Yamada, H., Yamakawa, N., Watanabe, M., Hidaka, Y., Iwatani, Y., Takano, T.: Prolonged hybridization with a cRNA probe improves the signal to noise ratio for in-tube in situ hybridization for quantification of mRNA after fluorescence-activated cell sorting. Biotech Histochem (in press)
  58. Morita, M., Watanabe, M., Inoue, N., Inaoka, C., Akamizu, T., Tatsumi, K., Hidaka, Y., Iwatani, Y.: Functional polymorphisms in TBX21 and HLX are associated with development and prognosis of Graves' disease. Autoimmunity, 45(2), 129-36, 2012
  59. Hanada, H., Mugii, S., Takeoka, K., Maeda, I., Watanabe, M., Hidaka, Y., Iwatani, Y.: Preparation of a cut-off solution that gives a clear index for distinguishing Le(a-b-) sera in CA19-9 assays using SphereLight 180 and Architect i2000 kits. Clinica Chemica Acta, 413(1-2), 278-281, 2012
  60. Tomizawa, R., Watanabe, M., Inoue N., Takemura, K., Hidaka, Y., Akamizu, T., Hayakawa, K., Iwatani, Y.: Association of functional GITR gene polymorphisms related to expression of GITR molecules with prognosis of autoimmune thyroid disease. Clin Exp Immunol, 165(2), 141-147, 2011
  61. Inoue, N., Watanabe, M., Morita, M., Tatsumi, K., Hidaka, Y., Akamizu, T., Iwatani, Y.: Association of functional polymorphisms in promoter regions of IL5, IL6, and IL13 genes with development and prognosis of autoimmune thyroid diseases. Clin Exp Immunol 163(3), 318-23, 2011
  62. Maruo, R., Yamada, H., Watanabe, M., Hidaka, Y., Iwatani, Y. Takano, T.: mRNA quantification after fluorescence activated cell sorting using locked nucleic acid probes. Mol Biotechnol, 49(1), 42-47, 2011
  63. Yamada, H., Takano, T., Matsuzuka, F., Watanabe, M., Miyauchi, A., Iwatani, Y.: Transcriptional activity of the 5'-flanking region of the thyroid transcription factor-1 gene in human thyroid cell lines. Genet Mol Biol 34(1), 6-10, 2011
  64. Inoue, N., Watanabe, M., Morita, M., Tomizawa, R., Akamizu, T., Tatsumi, K., Hidaka, Y., Iwatani, Y.: Association of functional polymorphisms related to the transcriptional level of FOXP3 with prognosis of autoimmune thyroid diseases. Clin Exp Immunol, 162(3), 402-406, 2010
  65. Yamada, H., Maruo, R., Watanabe, M., Hidaka, Y., Iwatani, Y., Takano, T.: Messenger RNA quantification after fluorescence activated cell sorting using in situ hybridization. Cytometry Part A, 77(11), 1032-1037, 2010
  66. Yamada, H., Maruo, R., Watanabe, M., Hidaka, Y., Iwatani, Y., Takano, T.: Messenger RNA quantification after fluorescence activated cell sorting using intracellular antigens. Biochem Biophys Res Commun. 397(3), 425-428, 2010
  67. Kuromoto, K., Watanabe, M., Adachi, K., Ohashi, K., Iwatani, Y.: Increases in urinary creatinine and blood pressure during early pregnancy in preeclampsia. Ann Clin Biochem, 47(Pt 4), 336-342, 2010
  68. Kuroda, S., Watanabe, M., Santo, T., Shimizuishi, Y., Takano, T., Hidaka, Y., Kimura, T., Iwatani, Y.: Postpartum increase of serum thioredoxin concentrations and the relation to CD8 lymphocytes. Ann Clin Biochem, 47(Pt 1), 62-66, 2010
  69. Hayashi, F., Watanabe, M., Nanba, T., Inoue, N., Akamizu, T., Iwatani, Y.: Association of -31C/T functional polymorphism in the interleukin-1beta gene with the intractability of Graves’ disease and the proportion of Th17 cells. Clin Exp Immunol, 158(3), 281-286, 2009
  70. Hanada, H., Mugii, S, Takeoka, K., Maeda, I, Watanabe, M., Hidaka, Y., Iwatani, Y.: Early detection of metastasis and relapse of colorectal cancer by recognizing NCA-2 in commercially available CEA assay. Clin Chem, 55(9), 1747-1751, 2009
  71. Nanba, T., Watanabe, M., Inoue, N., Iwatani, Y.: Increases of the Th1/Th2 cell ratio in severe Hashimoto's disease and in the proportion of Th17 cells in intractable Graves' disease. Thyroid 19(5), 495-501, 2009
  72. Inoue, N., Watanabe, M., Nanba, T., Wada, M., Akamizu, T., Iwatani, Y.: Involvement of functional polymorphisms in the TNFA gene in the pathogenesis of autoimmune thyroid diseases and production of anti-TSH receptor antibody. Clin Exp Immunol 156(2), 199-204, 2009
  73. Yamada H., Takano, T., Ito, Y., Matsuzuka, F., Miya, A., Kobayashi, K., Yoshida, H., Watanabe, M., Iwatani, Y., Miyauchi, A.:Expression of nestin mRNA is a differentiation marker in thyroid tumors. Cancer Lett 280(1), 61-64, 2009
  74. Kita，M., Deguchi, M.，Kagita，M., Yoshioka, N.，Kobayashi, E., Watanabe, M., Asari, S.，Yamanaka, K.，Iwatani, Y.: Clinical utility and characteristics of nine anti-HCV antibody screening reagents used in Japan. Clinical Laboratory 55, 9-22, 2009
  75. Nanba, T., Watanabe, M., Akamizu, T., Iwatani, Y.: The -590CC genotype in interleukin-4 gene as a strong predictive factor for the development of hypothyroidism in Hashimoto's disease. Clin Chem 54(3), 621-623, 2008
  76. Watanabe, M., Nakamura, Y., Matsuzuka, F., Takamura, Y., Miyauchi, A., Iwatani, Y.: Decrease of intrathyroidal CD161+Valpha24+Vbeta11+ NKT cells in Graves’ disease. Endocrine J 55(1), 191-203, 2008
  77. Hatanaka, N., Yamamoto, Y., Ichihara, K., Sato, A., Chihara, K., Nakamura, Y., Watanabe, M., Iwatani, Y.: A new predictive indicator for development of pressure ulcer in bedridden patients based on common laboratory tests results. J Clin Pathol 61(4), 514-518. 2008
  78. Yamada, H., Watanabe, M., Nanba, T., Akamizu, T., Iwatani, Y.: The 869T/C polymorphism in the transforming growth factor-beta1 gene is associated with the severity and intractability of autoimmune thyroid disease. Clin Exp Immunol 151, 379-82, 2008
  79. Santoh, T., Watanabe, M., Kuroda, S., Ueda, D., Iwatani, Y.: Ratio of serum IgG3 to total IgG concentration ond goiter size are independent factors in intractability of Graves' disease. Endocrine J 54(6), 887-894, 2007
  80. Yoshioka, N., Deguchi, M., Kagita, M., Kita, M., Watanabe, M., Asari, S., Iwatani, Y.: Evaluation of a chemiluminescent microparticle immunoassay for determination of Treponema pallidum antibodies. Clin Lab 53, 597-603, 2007
  81. Nakano, A., Watanabe, M., Iida, T., Kuroda, S., Matsuzuka, F., Miyauchi, A., Iwatani, Y.: Apoptosis-induced decrease of intrathyroidal CD4+CD25+ regulatory T cells in autoimmune thyroid diseases. Thyroid, 17(1), 25-31, 2007
  82. Ito, C., Watanabe, M., Okuda, N., Watanabe, C., Iwatani, Y.: Association between the severity of Hashimoto’s disease and the functional +874A/T polymorphism in the interferon-gamma gene. Endocrine J 53, 473-478, 2006
  83. Nagahama, D., Yoshiko, K., Watanabe, M., Morita, Y., Iwatani, Y., Matsuo, S: A useful new classification of dysmorphic urinary erythrocytes.  Clin Exp Nephrol, 9, 304-9, 2005
  84. Nakamura, Y., Watanabe, M., Matsuzuka, F., Miyauchi, A., Iwatani, Y.: Intrathyroidal CD4+ T lymphocytes express high levels of Fas and CD4+CD8+ macrophages / dendritic cells express Fas ligand in autoimmune thyroid disease. Thyroid, 14(10), 819-824, 2004
  85. Yamamoto, N., Watanabe, M., Matsuzuka, F., Miyauchi, A., Iwatani, Y.: Lower concentration of serum soluble CD8 in severe Hashimoto's disease. Clin Exp Immunol, 137, 601-605, 2004
  86. Watanabe, M., Yamamoto, N., Matsuzuka, F., Miyauchi, A., Iwatani, Y.: Decrease of CD154 intensity on peripheral CD4+ T cells in autoimmune thyroid disease. Clin Exp Immunol, 136, 555-558, 2004
  87. Maruoka, H., Watanabe, M., Matsuzuka, F., Takimoto, T., Miyauchi, A., Iwatani, Y.: Increased intensities of Fas expression on peripheral T cell subsets in severe autoimmune thyroid disease. Thyroid , 14(6), 417-423, 2004
  88. Takeoka, K., Watanabe, M., Matsuzuka, F., Miyauchi, A., Iwatani, Y.: Increase of serum Interleukin-10 in intractable Graves' disease. Thyroid , 14(3), 201-205, 2004
  89. Shinoda, R., Watanabe, M., Nakamura, Y., Maruoka, H., Kimura, Y., Iwatani, Y.: Physiological changes of Fas expression in peripheral lymphocyte subsets during the menstrual cycle. J Reprod Immunol, 60, 159-168, 2003
  90. Yamamoto, S., Iwasaki, Y., Mino, N., Watanabe, M.: Basic study on human psychological and physiological characteristics in responses to existing plants in urban parks. Journal of the Japanese Institute of Landscape Architecture, International Edition, 2, 25-30, 2003
  91. Komatsu, M., Kato, H., Aihara, M., Shimakawa, K., Iwasaki, M., Nagasaka, Y., Fukuda, S., Matsuo, S., Arakawa, Y., Watanabe, M., Iwatani, Y.: High Frequency of Antibiotic-Associated Diarrhea due to Toxin A-Negative, Toxin B-Positive Clostridium difficile in a Hospital in Japan and Risk Factors for Infection. Eur J Clin Microbiol Infect, 22(9), 525-9, 2003
  92. Nakamoto, Y., Niki, M., Watanabe, M., Iwatani, Y.: Increase of immunoglobulin G3-secreting cells in intractable Graves' disease. Thyroid , 13(4), 325-331, 2003
  93. Asari, S., Deguchi, M., Tahara, K., Taniike, M., Toyokawa, M., Nishi, I., Watanabe, M., Iwatani, Y., Makimoto, K.: Seroprevalence survey of measles, rubella, varicella, and mumps antibodies in health care workers and evaluation of vaccination program in a tertiary care hospital in Japan. Am J Infect Control, 31(3), 157-162, 2003
  94. Watanabe, M., Yamamoto, N., Maruoka, H., Matsuzuka, F., Miyauchi, A., Iwatani, Y.: Relation of CD30 molecules on T cell subsets to the severity of autoimmune thyroid disease. Thyroid , 13(3), 261-265, 2003
  95. Watanabe, M., Yamamoto, N., Maruoka, H., Tamai, H., Matsuzuka, F., Miyauchi, A., Iwatani, Y.: Independent involvement of CD8+CD25+ cells and thyroid autoantibodies in disease severity of Hashimoto's disease. Thyroid, 12(9), 801-808, 2002
  96. Watanabe, K., Watanabe, M., Maruoka, H., Amino, N., Iwatani, Y.: Increase of CD5+ B cells during adolescence in female mice.Mech Aging Develop, 122(15), 1787-1795, 2001
  97. Iwatani, Y. and Watanabe, M.: Normal mechanisms for self-tolerance. In Autoimmune Endocrinopathies (edited by Volpe R.), Humana Press, INC., Totawa, 1-30, 1999
  98. Iwatani, Y. and Watanabe, M.: The maternal immune system in health and disease. Curr Opin Obstet Gynecol, 10, 453-458, 1998
  99. Watanabe, M., Amino, N., Hochito, K., Watanabe, K., Kuma, K., Iwatani, Y.: Opposite Changes in Serum Soluble CD8 in Patients at the Active Stages of Graves' and Hashimoto's Disease Thyroid, 7(5), 743-747, 1997

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