我々の開発した治療的核酸は、大腸炎モデルマウス (Mol Ther Nucleic Acids 12 658-671 2018.) や担癌マウス (Mol Cancer Ther 17(5) 977-987 2018) に対して治療効果を示すことを明らかにした。また、アジュバンドであるCpG核酸の効果を増強する方法の開発に成功した (Front Immunol 9 783 2018)。

• miR-4711-5p regulates cancer stemness and cell cycle progression via KLF5, MDM2 and TFDP1 in colon cancer cells. Morimoto Y, Mizushima T, Wu X, Okuzaki D, Yokoyama Y, Inoue A, Hata T, Hirose H, Qian Y, Wang J, Miyoshi N, Takahashi H, Haraguchi N, Matsuda C, Doki Y, Mori M, Yamamoto H. Br J Cancer 122(7):1037-1049 2020.
• The Supercarbonate Apatite-MicroRNA Complex Inhibits Dextran Sodium Sulfate-Induced Colitis. Fukata T, Mizushima T, Nishimura J, Okuzaki D, Wu X, Hirose H, Yokoyama Y, Kubota Y, Nagata K, Tsujimura N, Inoue A, Miyoshi N, Haraguchi N, Takahashi H, Hata T, Matsuda C, Kayama H, Takeda K, Doki Y, Mori M, Yamamoto H. Mol Ther Nucleic Acids 12 658-671 2018. 
• A miR-29b Byproduct Sequence Exhibits Potent Tumor-Suppressive Activities via Inhibition of NF-κB Signaling in KRAS-Mutant Colon Cancer Cells. Inoue A, Mizushima T, Wu X, Okuzaki D, Kambara N, Ishikawa S, Wang J, Qian Y, Hirose H, Yokoyama Y, Ikeshima R, Hiraki M, Miyoshi N, Takahashi H, Haraguchi N, Hata T, Matsuda C, Doki Y, Mori M, Yamamoto H. Mol Cancer Ther 17(5) 977-987 2018. 
• Concurrent Targeting of KRAS and AKT by MiR-4689 Is a Novel Treatment Against Mutant KRAS Colorectal Cancer. Hiraki M, Nishimura J, Takahashi H, Wu X, Takahashi Y, Miyo M, Nishida N, Uemura M, Hata T, Takemasa I, Mizushima T, Soh JW, Doki Y, Mori M, Yamamoto H. Mol Ther Nucleic Acids 4 e231 2015.
• Functional assessment of miR‑1291 in colon cancer cells Wang J, Yokoyama Y, Hirose H, Shimomura Y, Bonkobara S, Itakura H, Kouda S, Morimoto Y, Minami K, Takahashi H, Shibata S, Kobayashi S, Uemura M, Tanaka S, Wu X, Tanaka S, Mori M, Yamamoto H. Int J Oncol 60(2) 13 2022 Feb.
• Improved In Vivo Delivery of Small RNA Based on the Calcium Phosphate Method Wu  X, Yokoyama Y, Takahashi H, Kouda S, Yamamoto H, Wang J, Morimoto Y, Minami K, Hata T, Shamma A, Inoue A, Ohtsuka M, Shibata S, Kobayashi S, Akai S, Yamamoto H. J Pers Med 11(11) 1160 2021,