[Original papers]
Setogawa S, Kanda R, Tada S, Hikima T, Saitoh Y, Ishikawa M, Nakada S, Seki F, Hikishima K, Matsumoto H, Mizuseki K, Fukayama O, Osanai M, Sekiguchi H*, Ohkawa N*.
A novel micro-ECoG recording method for recording multisensory neural activity from the parietal to temporal cortices in mice.
Molecular Brain 16: 38, 2023.

池田 尚人, 魯 文広, 鶴岡 典子, 虫明 元, 小山内 実, 大城 朝一, 芳賀 洋一.
光刺激部または内視鏡観察部周囲に電極を配置したチューブ形状神経電極.
電気学会論文誌 E 142(4): 48-55, 2022.

Tanihira H, Fujiwara T, Kikuta S, Homma N, Osanai M.
Manganese Dynamics in Mouse Brain After Systemic MnCl2 Administration for Activation-Induced Manganese-Enhanced MRI.
Frontiers in Neural Circuits 15: 787692, 2021.

Fukabori R, Iguchi Y, Kato S, Takahashi K, Eifuku S, Tsuji S, Hazama A, Uchigashima M, Watanabe M, Mizuma H, Cui Y, Onoe H, Hikishima K, Yasoshima Y, Osanai M, Inagaki R, Fukunaga K, Nishijo T, Momiyama T, Benton R, Kobayashi K.
Enhanced retrieval of taste associative memory by chemogenetic activation of locus coeruleus norepinephrine neurons.
Journal of Neuroscience 40: 8367-8385, 2020.

Kikuta S, Iguchi Y, Kakizaki T, Kobayashi K, Yanagawa Y, Takada M, Osanai M.
Store-operated calcium channels are involved in spontaneous slow calcium oscillations in striatal neurons.
Frontiers in Cellular Neuroscience 13: 547, 2019.

Inami C, Tanihira H, Kikuta S, Ogasawara O, Sobue K, Kume K, Osanai M, Ohsawa M.
Visualization of brain activity in a neuropathic pain model using quantitative activity-dependent manganese magnetic resonance imaging.
Frontiers in Neural Circuits 13: 74, 2019.

Ghandour K, Ohkawa N, Chung C, Fung A, Asai H, Saitoh Y, Takekawa T, Okubo-Suzuki R, Soya S, Nishizono H, Matsuo M, Osanai M, Sato M, Ohkura M, Nakai J, Hayashi Y, Sakurai T, Kitamura T, Fukai T, Inokuchi K.
Orchestrated ensemble activities constitute a hippocampal memory engram.
Nature Communications 10: 2637, 2019.

Moriguchi S, Kita S, Fukaya M, Osanai M, Inagaki R, Sasaki Y, Izumi H, Horie K, Takeda J, Saito T, Sakagami H, Saido TC, Iwamoto T, Fukunaga K.
Reduced expression of Na+/Ca2+ exchangers is associated with cognitive deficits seen in Alzheimer's disease model mice.
Neuropharmacology 131:291-303, 2017.

Ostrovidov S, Ebrahimi M, Bae H, Nguyen HK, Salehi S, Kim SB, Kumatani A, Matsue T, Shi X, Nakajima K, Hidema S, Osanai M, Khademhosseini A.
Gelatin-Polyaniline Composite Nanofibers Enhanced Excitation-Contraction Coupling System Maturation in Myotubes.
ACS Applied Materials & Interfaces 9(49):42444-42458, 2017.

Kikuta S, Ynagawa Y, Homma N, Osanai M.
Evaluation of the amount of the manganese entry in the neurons for activity-induced manganese-enhanced MRI.
Electronics and Communications in Japan 99(8): 48-53, 2016.

Kikuta S, Nakamura Y, Yamamura Y, Tamura A, Homma N, Yanagawa Y, Tamura H, Kasahara J, Osanai M.
Quantitative activation-induced manganese-enhanced MRI reveals severity of Parkinson's disease in mice.
Scientific Reports 5: 12800, 2015.

Kikuta S, Yanagawa Y, Homma N, Osanai M.
Evaluation of the amount of the manganese entry in the neurons for activity-induced manganese-enhanced MRI.
IEEJ Transactions on Electronics Information and Systems 135(3): 280-284, 2015.

Zhang X, Chikushima N, Watanabe A, Ohashi Y, Hasegawa N, Ichiji K, Tamura A, Osanai M, Homma N.
Is mammographic breast density a risk factor for breast cancer in Japanese women?
Bulletin of School of Health Sciences Tohoku University 24: 45-51, 2015.

Tamura A, Yamada N, Yaguchi Y, Machida Y, Mori I, Osanai M.
Both neurons and astrocytes exhibited tetrodotoxin-resistant metabotropic glutamate receptor-dependent spontaneous slow Ca2+ oscillations in striatum.
PLoS ONE 9(1): e85351, 2014. [PLoS ONE]

Homma N, Takai Y, Endo H, Ichiji K, Narita Y, Zhang X, Sakai M, Osanai M, Abe M, Sugita N, Yoshizawa M.
Markerless lung tumor motion tracking by dynamic decomposition of x-ray image intensity.
Journal of Medical Engineering 2013: 340821, 2013. [Hindawi]

Osanai M, Suzuki T, Tamura A, Yonemura T, Mori I, Yanagawa Y, Yawo H, Mushiake H.
Development of a micro-imaging probe for functional brain imaging.
Neurosci. Res. 75: 46-52, 2013. [Elsevier]

Mori I, Machida Y, Osanai M, Iinuma K
Photon starvation artifacts of X-ray CT: their true cause and a solution.
Radiol. Phys. Technol. 6: 130-141, 2013. [Springer]

Kikuta S, Tamura A, Kikuchi K, Yanagawa Y, Mori I, Osanai M
The spontaneous calcium transients lead to opening the store operated channels in the striatal cells.
Bull. Sch. Health Sci. Tohoku Univ. 21: 77-86, 2012.

Osanai M, Yaguchi Y, Yamada N, Oboshi F, Yagi T.
Spontaneous calcium changes in striatal cells.
Electronics and Communications in Japan 94(7): 43-52, 2011. [Wiley]

Sato K, Sakamoto H, Goto M, Osanai M, Machida Y, Mori I.
A Method of CT Simulation for Users by Using Projection Data Processing.
Bull. Sch. Health Sci. Tohoku Univ. 20: 91-102, 2011.

Goto M, Sato K, Minakuchi S, Miura T, Osanai M, Machida Y, Mori I.
Noise analysis of CT image: improvement in low-frequency area.
Bull. Sch. Health Sci. Tohoku Univ. 20: 55-61, 2011.

Tamura A, Yagi T, Osanai M.
Recording of the neural activity induced by the electrical subthalamic stimulation using Ca2+ imaging.
IEEJ Trans. EIS 131: 42-49, 2011. [J-STAGE]

Osanai M, Tanaka S, Takeno Y, Takimoto S, Yagi T.
Spatiotemporal Properties of the Action Potential Propagation in the Mouse Visual Cortical Slice Analyzed by Calcium Imaging.
PLoS ONE 5: e13738, 2010. [PLoS ONE]

Miura T, Minakuti S, Kato M, Goto M, Chiba S, Kimura T, Sato K, Osanai M, Machida Y, Mori I.
SSP Measurement of MDCT : The Flaw of Slant Wire Method and Improvement by Cross Wire Method.
Bull. Sch. Health Sci. Tohoku Univ. 19: 95-106, 2010.

Chimoto Y, Nakata E, Komamura K, Nagasawa Y, Watanabe S, Saito H, Mori I, Tamura H, Machida Y, Ishibashi T, Chida K, Shidahara M, Osanai M, et al.
The Combination of S-1 and Oxaliplatin Enhance the Antitumor Activity in vivo and in vitro in a Human Ovarian Cancer Model.
Bull. Sch. Health Sci. Tohoku Univ. 19: 107-115, 2010.

Takane Y, Sato A, Fujiwara R, Mishina M, Odagiri H, Nanbu T, Kodama H, Abe Y, Yanagawa I, Ishibashi T, Takai Y, Saitou H, Mori I, Tamura G, Mahcida Y, Chida K, Osanai M, et al.
A phantom study of comparison of cardiac SPECT analysis.
Bull. Sch. Health Sci. Tohoku Univ. 18: 83-92, 2009.

Ishiki T, Tanaka S, Osanai M, Doi S, Kumagai S, Yagi T.
Bifurcation-Based Model Construction of a Pyramidal Cell of the Primary Visual Cortex.
Int. J. Innov. Comp. Inf. Control 5: 831-845, 2009. [IJICIC]

Ishiki T, Tanaka S, Osanai M, Doi S, Kumagai S, Yagi T.
Global bifurcation analysis of a pyramidal cell model of the primary visual cortex: towards a construction of physiologically plausible model.
Lecture Notes in Computer Science 4984: 7-17, 2008. [Springer]

Osanai M, Yaguchi Y, Yamada N, Oboshi F, Yagi T.
Spontaneous calcium changes in striatal cells.
IEEJ Trans. EIS 128: 1050-1057, 2008. [J-STAGE]

Osanai M, Sakaehara H, Sawai H, Song W-J, Yagi T.
Optical recording of retinal and visual cortical responses evoked by electrical stimulation on the retina.
IEEJ Trans. EIS 127 (10): 1595-1602, 2007. [J-STAGE]

Osanai M, Kitagawa T, Yagi T.
Evaluation of effects of electrical stimulation on the retinal ganglion cells for the retinal prosthesis.
Trans. Jpn. Soc. Med. Biol. Eng. 45 (1): 63-69, 2007.

Osanai M, Yamada N, Yagi T.
Long lasting spontaneous calcium transients in the striatal cells.
Neurosci. Lett. 402: 81-85, 2006. [PubMed]

Osanai M, Saegusa H, Kazuno A, Nagayama S, Hu Q, Zong S, Murakoshi T, Tanabe T.
Altered cerebellar function in mice lacking CaV2.3 Ca2+ channel.
Biochem. Biophys. Res. Commun. 344: 920-5, 2006. [PubMed]

Fang X, Sakaguchi H, Fujikado T, Osanai M, Ikuno Y, Kamei M, Ohji M, Yagi T, Tano Y.
Electrophysiological and histological studies of chronically implanted intrapapillary microelectrodes in rabbit eyes.
Graefes. Arch. Clin. Exp. Ophthalmol. 244: 364-375, 2006. [PubMed]

Fang X, Sakaguchi H, Fujikado T, Osanai M, Kanda H, Ikuno Y, Kamei M, Ohji M, Gan D, Choi J, Yagi T, Tano Y.
Direct stimulation of optic nerve by electrodes implanted in optic disc of rabbit eyes.
Graefes. Arch. Clin. Exp. Ophthalmol. 243: 49-56, 2005. [PubMed]

Sakaguchi H, Fujikado T, Kanda H, Osanai M, Fang X, Nakauchi K, Ikuno Y, Kamei M, Ohji M, Yagi T, Tano Y.
Electrical stimulation with a needle-type electrode inserted into the optic nerve in rabbit eyes.
Jpn. J. Ophthalmol. 48: 552-557, 2004. [PubMed]

Sakaguchi H, Fujikado T, Fang X, Kanda H, Osanai M, Nakauchi K, Ikuno Y, Kamei M, Yagi T, Nishimura S, Ohji M, Yagi T, Tano Y.
Transretinal electrical stimulation with a suprachoroidal multichannel electrode in rabit eyes.
Jpn. J. Ophthalmol. 48: 256-261, 2004. [PubMed]

Sakata Y, Saegusa H, Zong S, Osanai M, Murakoshi T, Shimizu Y, Noda T, Aso T, Tanabe T.
CaV2.3 (α1E) Ca2+ channel participates in the control of sperm function.
FEBS Lett. 516: 229-233, 2002. [PubMed]

Toriyama H, Wang L, Saegusa H, Zong S, Osanai M, Murakoshi T, Noda T, Ohno K, Tanabe T.
Role of CaV2.3 (α1E) Ca2+ channel in ischemic neuronal injury.
Neuroreport 13: 261-265, 2002. [PubMed]

Suzuki S, Osanai M, Mitsumoto N, Akita T, Narita K, Kijima H, Kuba K.
Ca2+-dependent Ca2+ clearance via mitochondrial uptake and plasmalemmal extrusion in frog motor nerve terminals.
J. Neurophysiol. 87: 1816-1823, 2002. [PubMed]

Sakata Y, Saegusa H, Zong S, Osanai M, Murakoshi T, Shimizu Y, Noda T, Aso T, Tanabe T.
Analysis of Ca2+ currents in spermatocytes from mice lacking CaV2.3 (α1E) Ca2+ channel.
Biochem. Biophys. Res. Commun. 288: 1032-1036, 2001. [PubMed]

Suzuki S, Osanai M, Murase M, Suzuki N, Ito K, Shirasaki T, Narita K, Ohnuma K, Kuba K, Kijima H.
Ca2+ dynamics at the frog motor nerve terminal.
Pflügers Arch. 440: 351-365, 2000. [PubMed]

Saegusa H, Kurihara T, Zong S, Minowa O, Kazuno A, Han W, Matsuda Y, Yamanaka H, Osanai M, Noda T, Tanabe T.
Altered pain responses in mice lacking a1E subunit of the voltage-dependent Ca2+ channel.
Proc. Natl. Acad. Sci. U S A 97: 6132-6137, 2000. [PubMed]

Toru S, Murakoshi T, Ishikawa K, Saegusa H, Fujigasaki H, Uchihara T, Nagayama S, Osanai M, Mizusawa H, Tanabe T.
Spinocerebellar ataxia type 6 mutation alters P-type calcium channel function.
J. Biol. Chem. 275: 10893-10898, 2000. [PubMed]

Narita K, Akita T, Osanai M, Shirasaki T, Kijima H, Kuba K.
A Ca2+-induced Ca2+ release mechanism involved in asynchronous exocytosis at frog motor nerve terminals.
J. Gen. Physiol. 112: 593-609, 1998. [PubMed]

Osanai M, Tsuji A, Suzuki N, Kijima H.
Presynaptic effects of a trinitrobenzene analogue at the frog neuromuscular junction.
J. Neurophysiol. 76: 1735-1743, 1996. [PubMed]

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[Book chapters]
虫明 元, 田中 徹, 片山 統裕, 小山内 実.
第 3 章 生理機能の解析 4 多機能生理計測プラットフォーム.
マウス&ラットモデル作製・解析プロフェッショナル, 先端モデル動物支援プラットフォーム (AdAMS) 編, 羊土社, 202-220, 2021.

Osanai M, Miwa H, Tamura A, Kikuta S, Iguchi Y, Yanagawa Y, Kobayashi K, Katayama N, Tanaka T, Mushiake H.
Multimodal Functional Analysis Platform: 1. Ultrathin Fluorescence Endoscope Imaging System Enables Flexible Functional Brain Imaging. Optogenetics (Yawo, H., Kandori, H., Koizumi, A., Kageyama, R. Eds.), Springer, Singapore, Advances in Experimental Medicine and Biology 1293: 471-479, 2021.

Tanaka T, Katayama N, Sakamoto K, Osanai M, Mushiake H.
Multimodal Functional Analysis Platform: 2. Development of Si Opto-Electro Multifunctional Neural Probe with Multiple Optical Waveguides and Embedded Optical Fiber for Optogenetics.
Optogenetics (Yawo, H., Kandori, H., Koizumi, A., Kageyama, R. Eds.), Springer, Singapore, Advances in Experimental Medicine and Biology 1293: 481-491, 2021.

Katayama N, Nakao M, Tanaka T, Osanai M, Mushiake H.
Multimodal Functional Analysis Platform: 3. Spherical Treadmill System for Small Animals.
Optogenetics (Yawo, H., Kandori, H., Koizumi, A., Kageyama, R. Eds.), Springer, Singapore, Advances in Experimental Medicine and Biology 1293: 493-500, 2021.

Mushiake H, Ohshiro T, Osawa SI, Hosaka R, Katayama N, Tanaka T, Yawo H, Osanai M.
Multimodal Functional Analysis Platform: 4. Optogenetics-Induced Oscillatory Activation to Explore Neural Circuits.
Optogenetics (Yawo, H., Kandori, H., Koizumi, A., Kageyama, R. Eds.), Springer, Singapore, Advances in Experimental Medicine and Biology 1293: 501-509, 2021.

小山内 実.
大脳における細胞内カルシウム振動と神経・認知機能, 認知機能とカルシウム―基礎と臨床― (小川純人 編), 医薬ジャーナル社, pp. 36-46, 2015.

小山内 実.
バイオイメージング, 臨床医工学・情報学スキルアップシリーズ 1 臨床医工学スキルアップ講座 (春名 正光 ら 編), 大阪大学出版会, pp. 81-102, 2010.

Osanai M, Takada M, Fujiwara T, Akagawa K, Yamaguchi K.
Analysis of the regulatory mechanisms of synaptic exocytosis using an autapse of cultured rat hippocampal neuron.
Neural Development (Uyemura K, Kawamura K, Yazaki T, Eds.), pp 481-485. Springer-Verlag Tokyo, 1999.

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[Reviews]
Osanai M, Hikishima K, Onoe H.
Editorial: Manganese-Enhanced MRI: A New Avenue of Functional and Structural Imaging in Neuroscience.
Frontiers in Neural Circuits 16: 918500, 2022.

小山内 実.
マルチスケールカルシウムイメージング技術.
日本材料科学会誌 材料の科学と工学 59(2): 38-41, 2022.

菊田 里美, 笠原 二郎, 小山内 実.
定量的マンガン造影MRI を用いた疾患モデル動物の神経活動計測.
日本放射線技術学会雑誌 75(8): 799-804, 2019.

小山内 実, 菊田 里美.
パーキンソン病の Visual View 「MRI によるパーキンソン病重症度の可視化」.
Frontiers in Parkinson Disease 10: 30-34, 2017.

小山内 実.
大脳における細胞内カルシウム振動と神経・認知機能.
CLINICAL CALCIUM 25(2): 49-57, 2015.

虫明 元, 大城 朝一, 九鬼 敏伸, 菊地 琴美, 小山内 実.
神経回路の振動計測と光遺伝学的操作による状態遷移.
生体の科学 64: 41-46, 2013.

小山内 実.
神経回路におけるカルシウム動態の光学イメージング計測.
東北大学医学部保健学科紀要 19: 1-12, 2010.

田野保雄, 瓶井資弘, 生野恭司, 辻川元一, 坂口裕和, 西田健太郎, 方肖雲, 杜兆江, 謝平, 不二門尚, 日下俊次, 森本壮, 中内一揚, 別所建一郎, 下條裕史, 大川賀孝, 北口善之, 福田淳, 澤井元, 三好智満, 八木哲也, 小山内実, 宋文杰, 三宅養三, 近藤峰生, 子安俊行, 坂井隆夫, 栗本幸英, 平形明人, 大路正人, Quiroz-Mercado Hugo, Ustariz-Gonzalez Orlando, Cecilia-Gonzalez Carmen, 太田淳, 徳田崇, 小澤素生, 古野間邦彦, 鐘堂健三, 大澤孝治, 中谷正義, 米澤栄二, 寺澤靖雄, 齊藤徹, 神田寛行, 上原昭宏, 篠原祥二, 吉田雅和, 田代洋行, 吉峰俊樹, 平田雅之, 齊藤洋一, 谷直樹, 黒田麻紗子, Delbeke Jea.
人工視覚システムの臨床応用を目指して.
日本眼科学会雑誌 113(3): 315-343, 2009.

小山内 実, 田邊 勉.
電位依存性カルシウムチャネルの分子薬理学.
Clinical Calcium 10(3): 116-122, 2000.

小山内 実, 鈴木 慎一, 鈴木 直哉, 木島 博正, 久場 健司.
シナプス前末端内のカルシウム濃度の可視化とその時間変化測定.
生物物理 37: 223-224, 1997.

小山内 実, 成田 和彦, 鈴木 直哉, 木島 博正, 久場 健司.
シナプス前終末のカルシウム動態と伝達物質放出.
細胞工学 16(1): 40-47, 1997.

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