著書・原著・その他論文

著書(書籍、教科書など)

  • 岡本成史.「4.感染性疾患、壊死性筋膜炎」.今日の整形外科治療指針第8版、土屋弘行、紺野愼一、田中康仁、田中栄、岩崎倫政、松田秀一 編、医学書院、pp. 143-144, 2021.

  • 岡本成史.第3章第3節 寝たきり高齢者における皮膚常在細菌叢と褥瘡.進化する皮膚科学,NTS, pp. 89-97, 2021.

  • 岡本成史.「第6章 褥瘡後感染症・日和見感染症」ヒト常在菌叢と生理機能・全身疾患、 シーエムシー出版, pp.315-325,2020.

  • 岡本成史. 第Ⅳ部 これからのワクチン 29. これからのワクチン開発の方向性、ワクチンー基礎から臨床までー  中山哲夫編、朝倉書店, pp. 238-249, 2018.

  • 岡本成史.Ⅰ感染症の基礎 感染症の制御 3. ワクチン. メディカルサイエンス微生物検査学<第二版>太田敏子、岡崎充宏、金森政人、古畑勝則、松村充、山本容正編、近代出版、pp. 78-81, 2016.

  • 杉谷加代、千田靖子、岡本成史.Ⅳ感染症の検体検査 消化器感染症. メディカルサイエンス微生物検査学<第二版>太田敏子、岡崎充宏、金森政人、古畑勝則、松村充、山本容正編、近代出版、pp. 334-342, 2016.

研究論文(原著、総説・英文雑誌)

  • Miyajima Y, Karashima S, Mizoguchi R, Kawakami M, Ogura K, Ogai K, Koshida A, Ikagawa Y, Ami Y, Zhu Q, Tsujiguchi H, Hara A, Kurihara S, Arakawa H, Nakamura H, Tamai I, Nambo H, Okamoto S. Prediction and causal inference of hyperuricemia using gut microbiota. Scientific Reports, 14(1): 9901, 2024. doi: 10.1038/s41598-024-60427-6

  • Suzuki F, Okamoto S, Nakai S, Miyagi S, Tsujiguchi H, Hara A, Nguyen TTT, Shimizu Y, Hayashi K, Suzuki K, Kasahara T, Nakamura M, Takazawa C, Ogawa A, Shibata A, Kannon T, Tajima A, Tsuboi H, Ogino N, Konoshita T, Takamura T, Sato K, Nakamura H. Association between animal protein intake, oral frailty and calf circumference in middle-aged and older adults: a cross-sectional analysis from the Shika study. BMJ Open, 14(2): e078129, 2024. doi: 10.1136/bmjopen-2023-078129

  • Ogai K, Nana BC, Lloyd YM, Arios JP, Jiyarom B, Awanakam H, Esemu LF, Hori A, Matsuoka A, Nainu F, Megnekou R, Leke RGF, Ekali GL, Okamoto S, Kuraishi T. Skin microbiome profile in people living with HIV/AIDS in Cameroon. Frontiers in Cellular and Infection Microbiology, 13: 1211899, 2023. doi: 10.3389/fcimb.2023.1211899

  • Koshida A, Karashima S, Ogura K, Miyajima Y, Ogai K, Mizoguchi R, Ikagawa Y, Hara S, Mizushima I, Fujii H, Kawano M, Tsujiguchi H, Hara A, Nakamura H, Okamoto S. Impact of gut microbiome on serum IgG4 levels in the general population: Shika-machi super preventive health examination results. Frontiers in Cellular and Infection Microbiology, 13: 1272398, 2023. doi: 10.3389/fcimb.2023.1272398

  • Furugaito M, Arai Y, Uzawa Y, Kamisako T, Ogura K, Okamoto S, Kikuchi K. Antimicrobial Susceptibility to 27 Drugs and the Molecular Mechanisms of Macrolide, Tetracycline, and Quinolone Resistance in Gemella sp. Antibiotics (Basel), 12(10): 1538, 2023. doi:DOI:10.3390/antibiotics12101538

  • Nana BC, Esemu LF, Besong ME, Atchombat DHN, Ogai K, Sobgui TMP, Nana CMM, Seumko'o RMN, Awanakan H, Ekali GL, Leke RGF, Okamoto S, Ndhlovu LC, Megnekou R. Soluble biomarkers of HIV-1-related systemic immune activation are associated with high plasma levels of growth factors implicated in the pathogenesis of Kaposi sarcoma in adults. Frontiers in Immunology, 14: 1216480, 2023. doi: 10.3389/fimmu.2023.1216480

  • Furuya H, Ogura K, Takemoto N, Watanabe S, Yamazaki A, Ogai K, Sugama J, Okamoto S. A multilocus sequence typing method of Staphylococcus aureus DNAs in a sample from human skin. Microbiology and Immunology, 67(19)438-446, 2023. doi: 10.1111/1348-0421.13094

  • Mizoguchi R, Karashima S, Miyajima Y, Ogura K, Kometani M, Aono D, Konishi S, Demura M, Tsujiguchi H, Hara A, Nakamura H, Yoneda T, Okamoto S, Satou K. Impact of gut microbiome on the renin-aldosterone system: Shika-machi Super Preventive Health Examination results. Hypertension Research, , 46(10): 2280-2292, 2023. doi: 10.1038/s41440-023-01334-7.

  • Yamazaki A, Ogura K, Minami K, Ogai K, Horiguchi T, Okamoto S, Mukai K. Oral microbiome changes associated with the menstrual cycle in healthy young adult females. Frontiers in Cellular and Infection Microbiology, 12: 1119602, 2023. doi: 10.3389/fcimb.2023.1119602.

  • Muranaka Y, Matsue M, Mizutani A, Kobayashi M, Sato K, Kondo A, Nishiyama Y, Ohata S, Nishi K, Yamazaki K, Nishii R, Shikano N, Okamoto S, Kawai K. Evaluation of L-Alanine Metabolism in Bacteria and Whole-Body Distribution with Bacterial Infection Model Mice. International Journal of Molecular Science, 24(5): 4775, 2023. doi: 10.3390/ijms24054775.

  • Ogura K, Endo M, Hase T, Negami H, Tsuchiya K, Nishiuchi T, Suzuki T, Ogai K, Sanada H, Okamoto S, Sugama J. Potential biomarker proteins for aspiration pneumonia detected by shotgun proteomics using buccal mucosa samples: a cross-sectional case-control study. Clinical Proteomics, 20(1): 9, 2023. doi: 10.1186/s12014-023-09398-w.

  • Nakai S, Suzuki F, Okamoto S, Miyagi S, Tsujiguchi H, Hara A, Nguyen TTT, Shimizu Y, Hayashi K, Suzuki K, Kasahara T, Nakamura M, Takazawa C, Kannon T, Tajima A, Tsuboi H, Ogino N, Konoshita T, Takamura T, Nakamura H. Association between Bone Mineral Density and Oral Frailty on Renal Function: Findings from the Shika Study. Healthcare (Basel), 11(3): 314, 2023. doi: 10.3390/healthcare11030314.

  • Sugiyama Y, Mori Y, Nara M, Kotani Y, Nagai E, Kawada H, Kitamura M, Hirano R, Shimokawa H, Nakagawa A, Minami H, Gotoh A, Sakanaka M, Iida N, Koyanagi T, Katayama T, Okamoto S, Kurihara S. Gut bacterial aromatic amine production: aromatic amino acid decarboxylase and its effects on peripheral serotonin production. Gut Microbes. 14(1): 2128605, 2022. doi: 10.1080/19490976.2022.2128605.

  • Miyajima Y, Karashima S, Ogai K, Taniguchi K, Ogura K, Kawakami M, Nambo H, Kometani M, Aono D, Demura M, Yoneda T, Tsujiguchi H, Hara A, Nakamura H, Okamoto S. Impact of gut microbiome on dyslipidemia in japanese adults: Assessment of the Shika-machi super preventive health examination results for causal inference. Frontiers in Cellular and Infection Microbiology, 12: 908997, 2022. doi: 10.3389/fcimb.2022.908997.

  • Muranaka Y, Mizutani A, Kobayashi M, Nakamoto K, Matsue M, Takagi F, Okazaki K, Nishi K, Yamazaki K, Nishii R, Shikano N, Okamoto S, Maki H, Kawai K. 123 I-BMIPP, a Radiopharmaceutical for Myocardial Fatty Acid Metabolism Scintigraphy, Could Be Utilized in Bacterial Infection Imaging. Pharmaceutics, 14(5): 1008, 2022. doi: 10.3390/pharmaceutics14051008.

  • Ogura K, Furuya H, Takahashi N, Shibata K, Endo M, Watanabe S, Cui L, Miyoshi-Akiyama T, Okamoto S, Ogai K, Sugama J. Interspecies Regulation between Staphylococcus caprae and Staphylococcus aureus Colonized on Healed Skin after Injury. Frontiers in Microbiology, 13: 818398, 2022. doi: 10.3389/fmicb.2022.818398.

  • Muranaka Y, Mizutani A, Kobayashi M, Nakamoto K, Matsue M, Nishi K, Yamazaki K, Nishii R, Shikano N, Okamoto S, Kawai K. Comparison of L- and D-Amino Acids for Bacterial Imaging in Lung Infection Mouse Model. International Journal of Molecular Sciences 23(5):2467, 2022. doi: 10.3390/ijms23052467.

  • Ogai K, Nana BC, Lloyd YM, Arios JP, Jiyarom B, Awanakam H, Esemu LF, Hori A, Matsuoka A, Nainu F, Megnekou R, Leke RGF, Ekali GL, Okamoto S, Kuraishi T. Skin microbiome profile of healthy Cameroonians and Japanese. Scientific Reports, 12: 1364, 2022. doi: 10.1038/s41598-022-05244-5.  

  • Okamoto S, Ogai K, Mukai K, Sugama J. Association of Skin Microbiome with the Onset and Recurrence of Pressure Injury in Bedridden Elderly People. Microorganisms, 9(8): 1603, 2021. doi: 10.3390/microorganisms9081603

  • Sumitomo T, Nakata M, Nagase S, Takahara Y, Honda-Ogawa M, Mori Y, Akamatsu Y, Yamaguchi M, Okamoto S, Kawabata S. GP96 drives exacerbation of secondary bacterial pneumonia following influenza A virus infection. mBio, 12(3): e326920, 2021. doi:10.1128/mBio.03269-20.

  • Suzuki F, Okamoto S, Miyagi S, Tsujiguchi H, Akinori Hara A, Nguyen TTT, Shimizu Y, Hayashi K, Suzuki K, Nakai S, Miyagi M, Kannon T, Tajima A, Tsuboi H, Konoshita T, Nakamura H. Relationship between Decreased Mineral Intake Due to Oral Frailty and Bone Mineral Density: Findings from Shika Study. Nutrients, 13(4): 1193, 2021. doi: 10.3390/NU13041193

  • Ogai K, Shibata K, Takahashi N, Ogura K, Okamoto S, Sugama J. Amplicon-based skin microbiome profiles collected by tape stripping with different adhesive film dressings: a comparative study. BMC Microbiology, 21(1): 54, 2021. doi: 10.1186/s12866-021-02122-4

  • Ishihara H, Ogura K, Nguyen VA, Miyohi-Akiyama T, Okamoto S, Takemoto N. Comparative genome analysis of three Group A Streptococcus dysgalactiae subsp. equisimilis strains isolated in Japan. Journal of Medical Microbiology, 70(3), 2021. doi: 10.1099/jmm.0.001322

  • Ogai K, Ogura K, Ohgi N, Park S, Aoki M, Urai T, Nagase S, Okamoto S, Sugama J. Stability of Skin Microbiome at Sacral Regions of Healthy Young Adults, Ambulatory Older Adults, and Bedridden Older Patients After 2 Years. Biological Research for Nursing, 23(1): 82-90, 2021. doi: 10.1177/1099800420941151

  • Shibata K, Ogai K, Ogura K, Urai T, Aoki M, Arisandi D, Takahashi N, Okamoto S, Sanada H, Sugama J. Skin Physiology and its Microbiome as Factors Associated with the Recurrence of Pressure Injuries. Biological Research for Nursing, 23(1): 75-81, 2021. doi: 10.1177/1099800420941100

  • Nguyen VA, Ogura K, Matsue M, Takemoto N, Mukai K, Nakajima Y, Hoang TL, Iwata Y, Sakai N, Wada T, Hashimoto W, Okamoto S, Ichimura H. Novel Hyaluronate Lyase Involved in Pathogenicity of Streptococcus dysgalactiae subsp. equisimilis. Frontiers in Microbiology, 11:552418, 2020. doi: 10.3389/fmicb.2020.552418

  • Nagase S, Karashima S, Tsujiguchi H, Tsuboi H, Miyagi S, Komeyama M, Aono D, Higashitani T, Demura M, Sakakibara H, Yoshida A, Hara A, Nakamura H, Takeda Y, Nambo H, Yoneda T, Okamoto S. Impact of Gut Microbiome on Hypertensive Patients with Low-Salt Intake: Shika Study Results. Frontiers in Medicine, 7:475, 2020. doi:10.3389/fmed.2020.00475

  • Nagase S, Ogai K, Urai T, Shibata K, Matsubara E, Murai K, Matsue M, Mori Y, Aoki M, Arisandi D, Sugama J, Okamoto S. Distinct Skin Microbiome and Skin Physiological Functions Between Bedridden Older Patients and Healthy People: A Single-Center Study in Japan. Frontiers in Medicine 7:101, 2020. doi: 10.3389/fmed.2020.00101

  • Arisandi D, Ogai K, Urai T, Aoki M, Minematsu T, Okamoto S, Sanada H, Nakatani T, Suga ma J. Exploring the Risk Factors for the Development of Recurrent Pressure Ulcer in Elderly Patients: A Prospective Observational Study. Journal of Wound Care 29 {S4): S14-S24, 2020. doi: 10.12968/jowc.2020.29.Sup4.S1

  • Matsue M, Ogura K, Sugiyama H, Miyoshi-Akiyama T,Takemori-Sakai Y, Iwata Y, Wada T, Okamoto S. Pathogenicity characterization of prevalent-type Streptococcus dysgalactiae subsp. equisimilis strains. Frontiers in Microbiology 11: 97, 2020. doi: 10.3389/fmicb.2020.00097

  • Ishihara H, Ogura K, Miyohi-Akiyama T, Nakamura M, Kaya H, Okamoto S. Prevalence and Genomic Characterization of Group A Streptococcus dysgalactiae subsp. equisimilis Isolated From Patients With Invasive Infections in Toyama Prefecture, Japan. Microbiology and Immunology 64(2): 113-122, 2020.

  • Nagase S, Kotani Y, Nakamura M, Matsuoka A, Okamoto S. Relationship between oral conditions and the gut microbiome in healthy adults in Ishikawa prefecture, Japan.
    Journal of Wellness and Health Care 43(2): 1-10, 2020.

  • Hase T, Miura Y, Nakagami G, Okamoto S, Sanada H, Sugama J. Food bolus-forming ability predicts incidence of aspiration pneumonia in nursing home older adults: a prospective observational study.
    Journal of Oral Rehabilitation 47(1): 53-60, 2020. 

  • Matsue M, Mori Y, Nagase S, Sugiyama Y, Hirano R, Ogai K, Ogura K, Kurihira S, Okamoto S. Measuring the antimicrobial activity of lauric acid against various bacteria in human gut microbiota by using a new method.
    Cell Transplantation 28(12): 1528-1541, 2019.

  • Benderli NC, Ogai K, Lloyd YM, Arios JP, Jiyarom B, Awanakam AH, Esemu LF, Hori A, Megnekou, R, Leke RGF, Kuraishi T, Okamoto S, Ekali GL. Feasibility of microbial sample collection on the skin from people in Yaounde, Cameroon. Drug Discoveries and Thereupics 13(6): 360-3364, 2019.

  • Ogai K, Nagase S, Mukai K, Iuchi T, Mori Y, Matsue M, Sugitani K, Sugama J, Okamoto S. A Comparison of Techniques for Collecting Skin Microbiome Samples: Swabbing versus Tape-Stripping
    Frontiers in Microbiology 9: 2362, 2018.

  • Okamoto S, Nagase S. Pathogenic mechanisms of invasive group A Streptococcus (GAS) infections by influenza virus-GAS superinfection.
    Microbiology and Immunology 62(3):141-149, 2018.

  • Nagase S, Matsue M, Mori Y, Honda-Ogawa M, Sugitani K, Sumitomo T, Nakata M, Kawabata S, Okamoto S. Comparison of antimicrobial spectrum and mechanisms of organic virgin coconut oil and lauric acid against bacteria
    Journal of Wellness and Health Care 41(1):87-95, 2017.

  • Yamada H, Nagase S, Takahashi K, Sakoda Y, Kida H, Okamoto S. Toll-like receptor 9 ligand D-type oligodeoxynucleotide D35 as a broad inhibitor for influenza A virus replication that is associated with suppression of neuraminidase activity
    Antiviral Research 129:81-92, 2016.

  • Yamada H, Nagao C, Haredy AM, Mori Y, Mizuguchi K, Yamanishi K, Okamoto S. Dextran sulfate-resistant A/Puerto Rico/8/34 influenza virus is associated withthe emergence of specific mutations in the neuraminidase glycoprotein
    Antiviral Research 111(2):69-77, 2014.

  • Haredy AM, Yamada H, Sakoda Y, Okamatsu M, Yamamoto N, Omasa T, Ohtake H, Mori Y, Kida H, Okamoto S, Okuno Y, Yamanishi K. Neuraminidase gene homology contributes to the protective activity of influenza vaccines prepared from the influenza library.
    Journal of General Virology 95(11):2365-2371, 2014.

  • Haredy AM, Takenaka N, Yamada H, Sakoda Y, Okamatsu M, Yamamoto N, Omasa T, Ohtake H, Mori Y, Kida H, Yamanishi K, Okamoto S.An MDCK cell culture-derived formalin-inactivated influenza virus whole-virion vaccine from an influenza virus library confers cross-protective immunity by intranasal administration in mice.
    Clinical and Vaccine Immunology 20(7):998-1007, 2013.

  • Yamada H, Moriishi E, Haredy AM, Takenaka N, Mori Y, Yamanishi K, Okamoto S. Influenza virus neuraminidase contributes to the dextran sulfate-dependent suppressive replication of some influenza A virus strains.
    Antiviral Research 96(3):344-352, 2012.

  • Tanimoto T, Haredy AM, Takenaka N, Tamura S, Okuno Y, Mori Y, Yamanishi K. Okamoto S. Comparison of the cross-reactive anti-influenza neutralizing activity of polymeric and monomeric IgA monoclonal antibodies.
    Viral Immunology 25(5):433-439, 2012.

  • Tang H, Moriishi E, Okamoto S, Okuno Y, Iso H, Asada H, Yamanishi K, Mori Y, for the Shozu Herpes Zoster (SHEZ) Study group. A community-based survey of varicella-zoster virus-specific immune responses in the elderly.
    Journal of Clinical Virology 55(1): 46-50, 2012.

  • Kawai T, Saito M, Nishikomori R, Yasumi T, Izawa K, Murakami T, Okamoto S, Mori Y, Nakagawa N, Imai K, Nonoyama S, Wada T, Yachie A, Ohmori K, Nakahata T, Heike T. Multiple reversions of an IL2RG mutation restore T cell function in an X-linked severe combined immunodeficiency patient.
    Journal of Clinical Immunology 32(4): 690-697, 2012.

  • Okamoto S, Matsuoka S, Takenaka N, Haredy AM, Tanimoto T, Gomi Y, Ishikawa T, Akagi T, Akashi M, Okuno Y, Mori Y, Yamanishi K. Intranasal immunization with a formalin-inactivated human influenza A virus whole-virion vaccine alone and intranasal immunization with a split-virion vaccine with mucosal adjuvants show similar levels of cross-protection. Clinical and Vaccine Immunology 19(7): 979-990, 2012.

  • Okamoto S, Yoshii H, Matsuura M, Kojima A, Ishikawa T, Akagi T, Akashi M, Takahashi M, Yamanishi K, Mori Y. Poly-γ-glutamic acid nanoparticles and aluminum adjuvant used as an adjuvant with a single dose of Japanese encephalitis virus-like particles provides effective protection from Japanese encephalitis virus.
    Clinical and Vaccine Immunology 19(1): 17-22, 2012.

  • Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsunoda S, Tsutsumi Y. Systematic characterization of mucosal and systemic immune responses elicited by interleukins as mucosal vaccine adjuvant against influenza virus.
    Journal of Virology 84(24): 12703-12712, 2010.

  • Somboonthum P, Koshizuka T, Okamoto S, Matsuura M, Gomi Y, Takahashi M, Yamanishi K, Mori Y. Rapid and efficient introduction of a foreign gene into bacterial artificial chromosome-cloned varicella vaccine by Tn7-mediated site-specific transposition.
    Virology 402(1): 215-221, 2010.

  • Okamoto S, Hata A, Sadaoka K, Yamanishi K, Mori Y. Comparison of varicella-zoster virus-specific immunity of patients with diabetes mellitus and healthy individuals.
    The Journal of Infectious Diseases 200(10): 1606-1610, 2009.

  • Okamoto S,Matsuura M,Akagi T, Akashi M, Tanimoto T, Ishikawa T, Takahashi M, Yamanishi K, Mori Y. Poly(gamma-glutamic acid) nano-particles combined with mucosal influenza virus hemagglutinin vaccine protects against influenza virus infection in mice.
    Vaccine 27(42): 5896-5905, 2009.

  • Okamoto S, Terao Y, Hasuike K, Hamada S, Kawabata S. A novel streptococcal leucine zipper protein (Lzp) binds to human immunoglobulins.
    Biochemical and Biophysical Research Communications 377(4): 1128-1134, 2008.

  • Sadaoka K, Okamoto S, Gomi Y, Tanimoto T, Yoshikawa T, Asano Y, Yamanishi K, Mori Y. Measurement of varicella-zoster virus (VZV)-specific cell-mediated immunity — Comparison of VZV-skin test and interferon-γ ELISPOT assay.
    The Journal of Infectious Diseases 198(9): 1327-1333, 2008.

  • Kunitomo E, Terao Y, Okamoto S, Rikimaru T, Hamada S, Kawabata S. Molecular and biological characterization of histidine triad protein in group A streptococci.
    Microbes and Infection 10(4): 414-423, 2008.

  • Okamoto S, Terao Y, Tamura Y, Hamada S, Kawabata S. Streptococcal immunoglobulin-binding protein Sib35 exerts stimulatory and mitogenic effects toward mouse B lymphocytes.
    FEMS Microbiology Letters 281(1): 73-81, 2008.

  • Okamoto S, Yoshii H, Ishikawa T, Akagi T, Akashi M, Takahashi M, Yamanishi K, Mori Y. Single dose of inactivated Japanese encephalitis vaccine with poly (γ-glutamic acid) nanoparticles provides effective protection from Japanese encephalitis virus.
    Vaccine 26(5): 589-594, 2008.

  • Somboonthum P, Yoshii H, Okamoto S, Koike M, Gomi Y, Uchiyama Y, Takahashi M, Yamanishi K, Mori Y. Generation of a recombinant Oka varicella vaccine expressing a mumps virus hemagglutinin-neuraminidase protein as a polyvalent live vaccine.
    Vaccine 25(52): 8741-8755, 2007.

  • Okamoto S, Yoshii H, Akagi T, Akashi M, Ishikawa T, Okuno Y, Takahashi M, Yamanishi K, Mori Y. Influenza hemagglutinin vaccine with poly (γ-glutamic acid) nanoparticles enhances the protection against influenza virus infection through both humoral and cell-mediated immunity.
    Vaccine 25(49): 8270-8278, 2007.

  • Okamoto S, Terao Y, Kaminishi H, Hamada S, Kawabata S. Inflammatory immune responses by water-insoluble α-glucans.
    Journal of Dental Research 86(3): 242-248, 2007.

  • Terao Y, Okamoto S, Kataoka K, Hamada S, Kawabata S. Protective immunity against Streptococcus pyogenes challenge in mice following immunization with fibronectin-binding protein.
    The Journal of Infectious Diseases 192(12): 2081-2091, 2005.

  • Okamoto S, Tamura Y, Terao Y, Hamada S, Kawabata S. Systemic immunization with streptococcal immunoglobulin-binding protein Sib35 induces protective immunity against group A Streptococcus challenge in mice.
    Vaccine 23(40): 4852-4859, 2005.

  • Okamoto S, Kawabata S, Terao Y, Fujitaka H, Okuno Y, Hamada S. The Streptococcus pyogenes capsule is required for adhesion of bacteria to virus-infected alveolar epithelial cells and lethal bacterial-viral superinfection.
    Infection and Immunity 72(10): 6068-6075, 2004.

  • Tamura F, Nakagawa R, Akuta T, Okamoto S, Hamada S, Maeda H, Kawabata S, Akaike T. Proapoptotic effect of proteolytic activation of matrix metalloproteinases by Streptococcus pyogenes thiol proteinase/Streptococcus pyrogenic exotixin B.
    Infection and Immunity 72(8): 4836-4847, 2004.

  • Okamoto S, Kawabata S, Fujitaka H, Uehira T, Okuno Y, Hamada S. Vaccination with formalin-inactivated influenza vaccine protects mice against lethal influenza-Streptococcus pyogenes superinfection.
    Vaccine 22(21-22): 2887-2893, 2004.

  • Okamoto S, Kawabata S, Nakagawa I, Okuno Y, Goto T, Sano K, Hamada S. Influenza A virus-infected hosts boost an invasive type of Streptococcus pyogenes infection in mice.
    Journal of Virology 77(7): 4104-4112, 2003.

  • Liu ZX, Ajipa O, Okamoto S, Govindarajan S, Dennert G. Extracellular nicotinamide adenine dinucleotide induces T cell apoptosis in vivo and in vitro.
    The Journal of Immunology 167(9): 4942-4947, 2001.

  • Okamoto S, Kawabata S, Nakagawa I, Hamada S. Administration of superantigens protects mice from lethal Listeria monocytogenes infection by enhancing cytotoxic T cells.
    Infection and Immunity 69(11): 6633-6642, 2001.

  • Liu ZX, Govindarajan S, Okamoto S, Dennert G. Fas-mediated apoptosis causes elimination of virus-specific cytotoxic T cells in the virus-infected liver.
    The Journal of Immunology 166(5): 3035-3041, 2001.

  • Liu ZX, Govindarajan S, Okamoto S, Dennert G. NK cells cause liver injury and facilitate the induction of T cell-mediated immunity to a viral liver infection.
    The Journal of Immunology 164(12): 6480-6486, 2000.

  • Liu ZX, Govindarajan S, Okamoto S, Dennert G. Fas- and tumor necrosis factor receptor 1-dependent but not perforin-dependent pathways cause injury in livers infected with an adenovirus construct in mice.
    Hepatology 31(3): 665-673, 2000.

  • Okamoto S, Azhipa O, Yu Y, Russo E, Dennert G. Expression of ADP-ribosyltransferase on normal T lymphocytes and effects of nicotinamide adenine dinucleotide on their function.
    The Journal of Immunology 160(9): 4190-4198, 1998.

  • Rikiishi H, Okamoto S, Sugawara S, Tamura K, Liu ZX, Kumagai K. Superantigenicity of helper T-cell mitogen (SPM-2) isolated from culture supernatants of Streptococcus pyogenes.
    Immunology 91(3): 406-413, 1997.

  • Yu Y, Okamoto S, Nemoto E, Dennert G. Molecular cloning of a functional murine arginine-specific mono ADP ribosyltransferase and its expression in lymphoid cells.
    DNA and Cell Biology 16(2): 235-244, 1997.

  • Nemoto E, Rikiishi H, Sugawara S, Okamoto S, Tamura K, Maruyama Y, Kumagai K. Isolation of a new superantigen with potent mitogenic activity to murine T cells from Streptococcus pyogenes.
    FEMS Immunology and Medical Microbiology 15(2-3): 81-91, 1996.

  • Ohteki T, Okamoto S, Nakamura M, Nemoto E, Kumagai E. Elevated production of interleukin 6 by hepatic MNC correlates with ICAM-1 expression on the hepatic sinusoidal endothelial cells in autoimmune MRL/lpr mice.
    Immunology Letters 36(2):145-152, 1993.

その他論文(英文プロシーディング、日本語総説ならびに解説など)

  • 岡本成史.ワクチン作製の基本と新技術.臨床検査 66(8): 911-917, 2022.

  • 岡本成史,大貝和裕.褥瘡とマイクロバイオーム.Monthly Book Derma 313: 54-60, 2021.

  • 岡本成史.寝たきり高齢者における皮膚細菌叢の構成変化と皮膚傷害への影響. 地域ケアリング,22: 56-59, 2020.

  • 岡本成史.ココナッツオイルの抗菌作用の範囲とその作用機序 食と健康 13: 88-98, 2020.

  • 岡本成史.寝たきり高齢者における皮膚常在細菌叢の特徴と褥瘡後感染症発症ととの関連性―マイクロバイオーム解析からみえたこと― 地域ケアリング 21(11): 93-98, 2019.

  • 北西昌代,白石大祐,白石晃一郎,岡本成史.ホワイトニングによって治療モチベーションの変化とセルフケアへの行動変容が起こった1例 北西昌代,白石大祐,白石晃一郎,岡本成史 The Journal of Cosmetic Oral Care 17(1): 7-13, 2018.

  • 岡本成史,大貝和裕,須釜淳子.寝たきり高齢者における皮膚常在細菌叢構成の変化.BIO Clinica 32(13):1300-1307, 2017.

  • 岡本成史.次世代インフルエンザワクチンの開発に向けて-これからのインフルエンザワクチンに必要な性状とその研究状況-.
    小児科臨床 67(4):600-606, 2014.

  • 岡本 成史. 「粘膜免疫による交叉防御」と「ワクチン用種ウイルス」に焦点を当てた次世代インフルエンザワクチン研究.
    薬学雑誌 133(3):313-321, 2013.

  • 岡本 成史,川端 重忠. A群レンサ球菌―インフルエンザウイルスとの複合感染による重症化―.
    炎症と免疫18(6):657-660,2010.

  • 岡本 成史, 森 康子. 帯状疱疹ワクチンに向けた取り組み.
    臨床と微生物36(6):69-73,2009.

  • 森 康子,岡本 成史. 水痘生ワクチンを用いた組換えウイルスの作製と組換え多価生ワクチンとしての応用.
    Medical Science Digest 34(9):436-439,2008.

  • 岡本 成史, 森 康子. 新しい多価ワクチンの作製法,水痘弱毒生ワクチンのベクターとしての応用.
    化学と生物 46(1):12–16,2008.

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    Interface Oral Health Science 2007, Watanabe M and Okuno O (Eds), Springer Japan, Tokyo, pp243-247, 2007.

  • Okamoto S,Kawabata S,Nakagawa I,Okuno Y,Goto T,Sano K,Hamada S.A model of invasive type of Streptococcus pyogenes infection after intranasal infection in influenza A virus.
    International Congress Series 1263. Option for the control of Influenza V, Kawaoka Y (Ed), Elsevier, Amsterdam, pp733-736, 2004.

  • 岡本 成史, 浜田 茂幸, 川端 重忠. 肺上皮におけるインフルエンザウイルスとレンサ球菌並行感染による重症化メカニズムの解明.
    感染・炎症・免疫33(4):322-324,2003.

  • 岡本 成史,浜田 茂幸. 文献と臨床の橋わたし−細菌感染症におけるスーパー抗原の役割─両刃の剣.
    The Nippon Dental Review (月刊日本歯科評論) 62(3):179–181,2002.

  • 菅原 俊二,岡本 成史,熊谷 勝男. スーパー抗原の感染における免疫学的役割.
    Annual Review免疫1995,200–207, 1995.

  • 岡本 成史. A群溶レン菌培養液中に検出されるVβ8+ T細胞活性化スーパー抗原 (sCAP)の分離とその生物学的性状.
    東北大学歯学雑誌 14(1):13-26, 1995.

  • 岡本 成史,恩田 時男,菅原 俊二,根本 英二,力石 秀実,田村 啓二,熊谷 勝男.溶連菌由来のスーパー抗原により活性化されるT細胞の新しい生物学的意義.
    Progress of antiviral research in Japan, pp. 81-91, 1993.