研究業績集

2009年

• Yamamoto E, Ino K, Miyoshi E, Inamori K, Abe A, Sumigama S, Iwase A, Kajiyama K, Shibata K, Nawa A, and Kikkawa F. (2009) N-acetylglucosaminyltransferase V regulates extravillous trophoblast invasion through glycosylation of α5β1 integrin. Endocrinology, 150(2), 990-999.
• Kitazume S, Oka R, Ogawa K, Futakawa S, Hagiwara Y, Takigawa H, Kato M, Kasahara A, Miyoshi E, Taniguchi N, Hashimoto Y. (2009) Molecular insights into β-galactoside α2,6-sialyltransferase secretion in vivo. Glycobiology, 19(5), 479-487.
• Osumi D, Takahashi M, Miyoshi E, Yokoe S, Lee SH, Noda K, Nakamori S, Gu J, Ikeda Y, Kuroki Y, Sengoku K, Ishikawa M, Taniguchi N. (2009) Core fucosylation of E-cadherin enhances cell-cell adhesion in human colon carcinoma, WiDr cells. Cancer Science 100(5), 888-895.
• Wang XC, Fukuda T, Li W, Gao CX, Kondo A, Matsumoto A, Miyoshi E, Taniguchi N, Gu J. (2009) Requirement of Fut8 for the expression of vascular endothelial growth factor receptor-2: a new mechanism for the emphysema-like changes observed in Fut8-deficient mice. J. Biochemistry, 145(5), 643-651.
• Sasaki N, Moriwaki K, Uozumi N, Noda K, Taiguchi N, Kameyama A, Narimatsu H, Takeishi S, Yamada M, Koyama N, Miyoshi E. (2009) E4-PHA-reactive oligosaccharides are a novel marker for hepatic progenitor cells. Glycoconjugate J. 26(9) 1213-23.
• Moriwaki K, Noda K, Furukawa Y, Oshima K, Uchiyama A, Nakagawa T, Taniguchi N, Daigo Y, Nakamura Y, Hayashi N, Miyoshi E. (2009) Deficiency of GMD leads to escape from NK cell-mediated tumor surveillance through modulation of TRAIL signaling. Gastroenterology 137(1), 188-198.
• Takahashi N, Yamamoto E, Ino K, Miyoshi E, Nagasawa T, Kajiyama H, Shibata K, Nawa A, Kikkawa F. (2009) High expression of N-acetylglucosaminyltransferase-V in mucinous tumors of the ovary. Oncology Reports 22(5), 1027-1032.

2008年

• Nakano M, Nakagawa T, Ito T, Kitada T, Hijioka T, Kasahara A, Tajiri M, Wada Y, Taniguchi N, Miyoshi E. (2008) Site-specific analysis of N-glycans on haptoglobin in sera of patients with pancreatic cancer; a novel approach for the development of tumor markers. Int. J Cancer 122(10), 2301-2309.
• Hayashi Y, Tsuji S, Tsujii M, Nishida T, Ishii S, Iijima H, Nakamura T, Eguchi H, Miyoshi E, Hayashi N, Kawano S. (2008) Topical Transplantation of Mesenchymal Stem Cells Accelerates Gastric Ulcer Healing in Rats. Am J Physiol Gastrointest Liver Physiol. 294(3), G778-86.
• Takahashi T, Naka T, Fujimoto M, Serada S, Horino J, Terabe F, Hirota S, Miyoshi E, Hirai T, Nakajima K, Nishitani A, Souma Y, Sawa Y, Nishida T. (2008) Aberrant expression of glycosylation in juvenile gastrointestinal stromal tumors. Proteomics Clin. Appl.2, 1246-1254.
• Nakagawa T, Miyoshi E, Yakushijin T, Ikura H, Hiramatsu N, Hayashi N, Taniguchi N, Kondo A. (2008) Structural and enzymatic bases of N-glycans of alpha-fetoprotein L2 and L3 from hepatoma cell lines and hepatocellular carcinoma patients. J. Proteome Research 7(6), 2222-2233.
• Hayashi Y, Tsuji S, Tsujii M, Nishida T, Ishii S, Iijima H, Nakamura T, Eguchi H, Miyoshi E, Hayashi N, Kawano S. (2008) Topical implantation of mesenchymal stem cells has beneficial effects on healing of experimental colitis in rats. J Pharmacol Exp Ther. 326(2), 523-31.
• Kasuya T, Jung J, Kadoya H, Matsuzaki T, Tatematsu K, Okajima T, Miyoshi E, Tanizawa K, Kuroda S. (2008) In Vivo Delivery of Bionanocapsules displaying phaseolus vulgaris agglutinin-L(4) isolectin to malignant tumors overexpressing N-acetylglucosaminyltransferase V. Human Gene Therapy (19), 887-895.
• Kim YS, Son OL, Lee JY, Kim SH, Oh S, Lee YS, Kim CH, Yoo JS, Lee JH, Miyoshi E, Taniguchi N, Hanash SM, Yoo HS, Ko JH. (2008) Lectin precipitation using phytohemagglutinin-L(4) coupled to avidin-agarose for serological biomarker discovery in colorectal cancer. Proteomics 8(16), 3229-3235.
• Inohara H, Segawa T, Miyauchi A, Yoshii T, Nakahara S, Raz Avraham, Maeda M. Miyoshi E, Kinoshita N, Yoshida H, Furukawa M, Takenaka Y, Takemura Y, Ito Y, Taniguchi N. (2008) Cytoplasmic and Serum galectin3 in diagnosis of thyroid malignancies. Biochem Biophys Res Commun. 376(3), 605-610.
• Narisada M, Kawamoto S, Kuwamoto K, Moriwaki K, Nakagawa T, Matsumoto H, Asahi M, Koyama N, Miyoshi E. (2008) Identification of an inducible factor secreted by pancreatic cancer cell lines that stimulates the production of fucosylated haptoglobin in hepatoma cells. Biochem Biophys Res Commun. 377 (3), 792-796.
• Tian H, Miyoshi E, Kawaguchi N, Shaker M, Ito Y, Taniguchi N, Tsujimoto M, Matsuura N. (2008) The implication of N-acetylglucosaminyltransferase V expression in gastric cancer. Pathobiology 75(5), 288-894.

2007年

• Yokoe S, Takahashi M, Asahi M, Lee S H, Li W, Osumi D, Miyoshi E, Taniguchi N. (2007) The Asn418-linked N-glycan of ErbB3 plays a crucial role in preventing spontaneous heterodimerization and tumor promotion. Cancer Res. 67(5), 1935-1942.
• Wada Y, Azadi P, Costello C, Dell A, Dwek RA, Geyer H, Geyer R, Kakehi K, Karlsson N, Kato K, Kawasaki N, Khoo KH, Kim S, Kondo A, Lattova E, Mechref Y, Miyoshi E, Nakamura K, Narimatsu H, Novotny M, Packer N, Perreault H, Peter-Katalini J, Pohlentz G, Reinhold V, Rudd M, Suzuki A,Taniguchi N. (2007) Comparison of the Methods for Profiling Glycoprotein Glycans: HUPO HGPI (Human Proteome Organisation Human Disease Glycomics/Proteome Initiative) Multi-institutional Study. Glycobiology 17(4), 411-422.
• Sasamura T, Ishikawa HO, Sasaki N, Higashi S, Kanai M, Nakao S, Ayukawa T, Aigaki T, Noda K, Miyoshi E, Taniguchi N, Matsuno K. (2007) The O-fucosyltransferase O-fut1 is an extracellular component that is essential for the constitutive endocytic trafficking of Notch in Drosophila. Development 134(7) 1347-1356.
• Li W, Takahashi M, Shibukawa Y, Yokoe S, Gu J, Miyoshi E, Honke K, Ikeda Y, Taniguchi N. (2007) Introduction of bisecting GlcNAc in N-glycans of adenylyl cyclase III enhances its activity.　 Glycobiology 17(6), 655-62.
• Matsumura K, Higashida K, Ishida H, Hata Y, Yamamoto K, Shigeta M, Mizuno-Horikawa Y, Wang X, Miyoshi E, Gu J, Taniguchi N. (2007) Carbohydrate-binding specificity of a fucose-specific lectin from aspergillus oryzae: A novel probe for core fucose. J. Biol. Chem 282(21), 15700-8.
• Kyan A, Kamimura N, Hagisawa S, Hatakeyama S, Koie T, Yoneyama T, Arai Y, Nakagawa H, Nishimura S, Miyoshi E, Hashimoto Y, Ohyama C. (2008) Positive expressions of N-acetylglucosaminyltransferase-V (GnT-V) and β1-6 branching N-linked oligosaccharides in human testicular germ cells diminish during malignant transformation and progression. Int. J. Oncology 32(1), 129-34.
• Handerson T, Berger A, Harigopol M, Rimm D, Nishigori C, Ueda M, Miyoshi E, Taniguchi N, Pawelek J. (2007) Melanophages reside in hypermelanotic, aberrantly glycosylated tumor areas and predict improved outcome in primary cutaneous malignant melanoma. J. Cutaneous Pathology 34(9), 679-686.
• Moriwaki K, Noda K, Nakagawa T, Asahi M, Yoshihara H, Taniguchi N, Hayashi N, Miyoshi E. (2007) A high expression of GDP-fucose transporter in hepatocellular carcinoma is a key factor for increases in fucosylation. Glycobiology 17(12), 1311-20.
• Sugimoto I, Futakawa S, Oka R, Ogawa K, Marth J D, Miyoshi E, Taniguchi N, Hashimoto Y, Kitazume S. (2007) ST6GalI Cleavage by BACE 1 enhances the sialylation of soluble glycoproteins: a novel regulatory mechanism for α2,6-sialylation. J. Biol. Chem. 282(48), 34896-903.
• Li W, Ishihara K, Yokota T, Nakagawa T, Koyama N, Mizuno-Horikawa Y, Wang X, Miyoshi E, Taniguchi N, Kondo A. (2007) Reduced α4β1integrin / VCAM-1 interactions lead to impaired pre-B cell repopulation in alpha 1,6-fucosyltransferase deficient mice. Glycobiology 18(1), 114-24.
• Yamamoto E, Ino K, Miyoshi E, Shibata K, Takahashi N, Kajiyama H, Nawa A, Nomura S, Nagasaka T, Kikkawa F. (2007) Expression of N-acetylglucosaminyltransferase V in endometrial cancer correlates with poor prognosis. British Journal of Cancer 97(11), 1538-44.
• Kim YS, Hwang SY, Kang HY, Sohn H, Oh S, Kim JY, Yoo JS, Kim YH, Kim CH, Jeon JH, Lee JM, Kang HA, Miyoshi E, Taniguchi N, Yoo HS, Ko JH. (2008) Functional proteomic study reveals that N-acetylglucosaminyl transferase V reinforces the invasive/metastatic potential of colon cancer through aberrant glycosylation on TIMP-1. Mol Cell Proteomics 7(1), 1-14.
• Kitada T, Murakami T, Kuzushita N, Minamitani K, Nakajo K, Osuga K, Miyoshi E, Nakamura H, Kishino B, Tamura S, Hayashi N. (2008) Effectiveness of Real-time virtual sonography-guided radiofrequency ablation treatment for patients with hepatocellualr carcinoma. Hepatol. Res 38(6), 565-571.
• Shinzaki S, Iijima H, Nakagawa T, Egawa S, Nakajima S, Ishii S, Irie T, Kakiuchi Y, Nishida T, Yasumaru M, Kanto T, Tsujii M, Tsuji S, Mizushima T, Yoshihara H, Kondo A, Miyoshi E, Hayashi N. (2008) IgG oligosaccharide alterations are novel diagnostic marker for disease activity and the clinical course of inflammatory bowel disease. Am. J. Gastroenterology 103(5), 1173-1181.
• Yamanaka K, Ito Y, Okuyama N, Noda K, Matsumoto H, Yoshida H, Miyauchi A, Capurro M, Filmus J, Miyoshi E. (2007) Immunohistochemical study of glypican3 in thyroid cancer. Oncology 73(5-6), 389-394.