研究業績集

2014年

• Azuma K, Shinzaki S, Asazawa H, Kuroki E, Kawamoto S, Kamada Y, Hayakawa K, Miyoshi E. (2014) Twin studies on the influence of genetic factors on serum agalactosyl immunoglobulin G level. Biomedical Reports 2: 213-216
• Onuki K, Sugiyama H, Ishige K, Kawamoto T, Ota T, Ariizumi S, Yamato M, Kadota S, Takeuchi K, Ishikawa A, Onodera M, Onizawa K, Yamamoto M, Miyoshi E, Shoda J. (2014) Expression of N-acetylglucosaminyltransferase V in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder. J Gastroenterol. 49(4), 702-714.
• Tomita Y, Azuma K, Nonaka Y, Kamada Y, Tomoeda M, Kishida M, Tanemura M, Miyoshi E. (2014) Pancreatic Fatty Degeneration and Fibrosis as Predisposing Factors for Development of Pancreatic Ductal Adenocarcinoma. Pancreas 43(7), 1032-41.
• Fujita K, Shimomura M, Umemura M, Nakata W, Sato M, Nagahara A, Nakai Y, Takamatsu S, Miyoshi E, Nonomura N. (2014) Serum fucosylated haptoglobin as a novel prognostic biomarker predicting a high Gleason score of prostate cancer. The Prostate 74(10), 1052-58.
• Azuma K, Serada S, Takamatsu S, Terao N, Takeishi S, Kamada Y, Naka T, Miyoshi E. (2014) Identification of sialylated glycoproteins in doxorubicin-treated hepatoma cells with glycoproteomic analyses. Journal of Proteome Research 13(11), 4869-77.
• Ohkura T, Fujioka Y, Nakanishi R, Shiochi H, Sumi K, Yamamoto N, Matsuzawa K, Izawa S, Ohlura H, Ueta E, Kato M, Miyoshi E, Taniguchi S, Yamamoto K. (2014) Low level galectin-3 concentrations are associated with insulin resistance in patients with type 2 diabetes mellitus. Diabetology & Metabolic syndrome Sep 27;6(1):106
• Furukawa K, Kawamoto K, Eguchi H, Tanemura M, Tomimaru Y, Akita H, hama N, Wada H, Kobayashi S, Nonaka Y, Takamatsu S, Shinzaki S, Kumada T, Satomura S, Ito T, Serada S, Naka T, Mori M, Doki Y, Miyoshi E, Nagano N. (2014) Clinico-pathological significance of leucine-Rich alpha-2-glycoprotein-1 in sera of patients with pancreatic cancer. Pancreas 44(1), 93-98.

2013年

• Kamada Y, Kinoshita N, Tsuchiya Y, Kobayashi K, Fujii H, Terao N, Kamihagi K, Koyama K, Yamada S, Daigo Y, Nakamura N, Taniguchi N, Miyoshi E. (2013) Reevaluation of a lectin antibody ELISA kit for measuring fucosylated haptoglobin in various conditions. Clin. Chim. Acta 417, 48-53.
• Shinzaki S, Kuroki E, Iijima H, Tatsunaka N, Ishii M, Fujii H, Kamada Y, Kobayashi T, Shibukawa N, Inoue T, Tsujii M, Takeishi S, Mizushima T, Ogata A, Naka T, Plevy S, Takehara T, Miyoshi E. (2013) Lectin-based immunoassay for aberrant IgG glycosylation as the biomarker for Crohn's disease. Inflamm Bowel Dis. 19(2), 321-331.
• Tanaka K, Moriwaki K, Yokoi S, Koyama K, Miyoshi E, Fukase K. (2013) Whole-body imaging of tumor cells by azaelectrocyclization: Visualization of metastasis dependence on glycan structure. Bioorg Med Chem. 21(5), 1074-1077.
• Kimura M, Masui Y, Shirai Y, Honda C, Moriwaki K, Imai T, Takagi U, Kiru T, Kiso T, Murakami H, Nakano H, Kitahata S, Miyoshi E, Tanimoto T. (2013) Preparation of Branched Cyclomaltoheptaose with 3-O-α-L-Fucopyranosyl-α- D-mannopyranose and Changes in Fucosylation of HCT116 Cells Treated with the Fucose-Modified Cyclomaltoheptaose. Carbohydrate Res. 374, 49-58.
• Onuki K, Sugiyama H, Ishige K, Kawamoto T, Ota T, Ariizumi S, Yamato M, Kadota S, Takeuchi K, Ishikawa A, Onodera M, Onizawa K, Yamamoto M, Miyoshi E, Shoda J. (2013) Expression of N-acetylglucosaminyltransferase V in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder. J Gastroenterol. 2013 Apr 17 in press.
• Kamada Y, Fujii H, Fujii H, Sawai Y, Doi Y, Uozumi N, Mizutani K, Akita M, Sato M, Kida S, Kinoshita N, Maruyama N, Yakushijin T, Miyazaki M, Ezaki H, Hiramatsu N, Yoshida Y, Kiso S, Imai Y, Kawada N, Takehara T, Miyoshi E. (2013) Serum Mac-2 binding protein levels as a novel diagnostic biomarker for prediction of disease severity and nonalcoholic steatohepatitis. Proteomics CA, 7, 648-656.
• Kamada Y, Akita M, Takeda Y, Yamada S, Fujii H, Sawai Y, Doi Y, Asazawa H, Nakayama K, Mizutani K, Fujii H, Yakushijin T, Miyazaki M, Ezaki H, Hiramatsu N, Yoshida Y, Kiso S, Imai Y, Kawada N, Takehara T, Miyoshi E. (2013) Serum fucosylated haptoglobin as a novel diagnostic biomarker for predicting hepatocyte ballooning and nonalcoholic steatohepatitis. PLOS ONE 8(6), e66328.
• Nakayama K, Moriwaki K, Imai K, Shinzaki S, Kamada Y, Murata K, Miyoshi E. (2013) Mutation of GDP-mannose-4,6-dehydratase in colorectal cancer. PLOS ONE 8(7), e70298.

2012年

• Korekana H, Hasagawa T, Matsumoto A, Kinoshita N, Miyoshi E, Taniguchi N. (2012) Development of an antibody lectin enzyme immunoassay for fucosylated alpha-fetoprotein. Biochim Biophys Acta. 1820(9), 1405-1411.
• Inoue T, Iijima H, Tajiri M, Shinzaki S, Shiraishi E, Hiyama S, Mukai A, Nakajima S, Yasui T, Iwatani H, Nishida T, Mizushima T, Isaka Y, Kanto T, Tsujii M, Miyoshi E, Wada Y, Takehara T. (2012) Deficiency of N-acetylgalactosamine in O-linked oligosaccharides of IgA is a novel biologic marker for inflammatory bowel diseases. IBD Journal 18(9), 1723-34.
• Kamada Y, Mori K, Matsumoto H, Kiso S, Yoshida Y, Shinzaki S, Hiramatsu N, Ishii M, Moriwaki K, Kawada N, Takehara T, Miyoshi E, (2012) N-Acetylglucosaminyltransferase V regulates TGF-? response in hepatic stellate cells and the progression of steatohepatitis. Glycobiology 22(6), 778-787.
• Shinzaki S, Iijima H, Fujii H, Kuroki E, Tatsunaka N, Inoue T, Nakajima S, Egawa S, Kanto T, Tsujii M, Morii E, Takeishi S, Asano M, Takehara T, Hayashi N, Miyoshi E. (2012) Altered oligosaccharide structures contribute to ameliorate murine colitis defective in beta 1,4 galactosyltransferase I. Gastroenterology 142 (5), 1172-82.
• Nakagawa T, Moriwaki K, Terao N, Nakagawa T, Miyamoto Y, Miyoshi E. (2012) Analysis of polarized secretion of fucosylated alpha-fetoprotein in HepG2 cells. J. Proteome Res. 11(5), 2798-2806.
• Kimura A, Terao M, Kato A, Hanafusa T, Murota H, Katayama I, Miyoshi E. (2012) Upregulation of N-acetylglucosaminyltransferase-V by heparin-binding EGF-like growth factor induces keratinocyte proliferation and epidermal hyperplasia. Experimental Dermatology 21(7), 515-519.
• Mehta AS, Norton P, Liang H, Comunale MA, Wang M, Rodemich-Betesh L, Koszycki A, Noda K, Miyoshi E, Block T. (2012) Increased levels of tetra-antennary N-linked glycan but not core fucosylation are associated with hepatocellular carcinoma tissue. Cancer Epidemiol Biomarkers Prev. 21(5), 925-933.
• Kobayashi Y, Tateno H, Dohra H, Moriwaki K, Miyoshi E, Hirabayashi J, Kawagishi H. (2012) A novel core fucose-specific lectin from the mushroom Pholiota squarrosa. J Biol Chem. 287(41), 33973-82.

2011年

• Nakajima S, Iijima H, Shinzaki S, Egawa S, Inoue T, Mukai A, Hayashi Y, Kondo J, Akasaka T, Nishida T, Kanto T, Morii E, Mizushima T, Miyoshi E, Tsujii M, Hayashi N. (2011) Functional Analysis of Agalactosyl IgG in Inflammatory Bowel Disease Patients: Association with Lectin Complement Pathway and Phagocytic Activity. IBD journal 17(4), 927-936.
• Moriwaki K, Okudo K, Haraguchi N, Takeishi S, Sawaki H, Narimatsu H, Tanemura M, Ishii H, Mori M, Miyoshi E. (2011) Combination use of anti-CD133 antibody and SSA lectin can effectively enrich the cells with high tumorigenicity. Cancer Science 102(6), 1164-70.
• Kawamoto S, Moriwaki K, Nakagawa T, Terao M, Shinzaki S, Yamane-Ohnuki N, Satoh M, Metha A, Block T, Miyoshi E. (2011) Overexpression of α1.6-fucosyltransferase in hepatoma enhances expression of Golgi phosphoprotein 2 in a fucosylation-independent manner. International Journal of Oncology 39(1), 203-208.
• Mukai　T, Hagimori M, Arimitsu K, Katoh T, Ukon M, Kajimoto T, Kimura H, Magata Y, Miyoshi E, Taniguchi N, Node M, Saji H. (2011) Synthesis and evaluation of a radioiodinated trisaccharide derivative as a synthetic substrate for a sensitive N-acetylglucosaminyltransferase V radioassay. Bioorganic & Medicinal Chemistry 19(14), 4312-4321.
• Terao M, Ishikawa A, Nakahara S, Kimura A, Kato A, Moriwaki K, Kamada Y, Murota H, Taniguchi N, Katayama I, Miyoshi E. (2011) Enhanced epithelial-mesenchymal transition-like phenotype in N-acetylglucosaminyl transferase V transgenic mouse skin promotes wound healing. J. Biol. Chem. 286 (32), 28303-28311.
• Takeda Y, Shinzaki S, Okudo K, Moriwaki K, Murata K, Miyoshi E. (2011) Fucosylated haptoglobin is a novel type of cancer biomarker linked to the prognosis after an operation in colorectal cancer. Cancer 118(12), 3036-43.
• Terao M, Murota H, Kimura A, Kato A, Ishikawa A, Igawa K, Miyoshi E, Katayama I. (2011) 11β-hydroxysteroid dehydrogenase-1 is a novel regulator of skin homeostasis and a candidate target for promoting tissue repair. PLoS One 6(9) :e25039.
• Uchida Y, Hasegawa J, Chinnapen D, Inoue T, Okazaki S, Kato R, Wakatsuki S, Misaki R, Koike M, Uchiyama Y, Iemura S, Natsume T, Kuwahara R, Nakagawa T, Nishikawa K, Mukai K, Miyoshi E, Taniguchi N, Sheff D, Lencer W, Taguchi T, Arai H. (2011) Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes. Proc. Natl. Acad. Sci. 108(38), 15846-15851.
• Moriwaki K, Shinzaki S, Miyoshi E. (2011) GMDS deficiency renders colon cancer cells resistant to TRAIL receptor- and CD95-mediated apoptosis by inhibiting complex II formation. J. Biol. Chem. 286(50), 43123-43133.

2010年

• Miyagawa S, Takeishi S, Yamamoto A, Ikeda K, Matsunari H, Yamada M, Okabe M, Miyoshi E, Fukuzawa M, Nagashima H. (2010) Survey of glycoantigens in cells from α1-3 galactosyltransferase knockout pig using a lectin microarray. Xenotransplantation 17(1), 61-70.
• Matsumoto H, Shinzaki S, Narisada M, Kawamoto S, Kuwamoto K, Moriwaki K, kanke F, Satomura S, Kumada T, Miyoshi E. (2010) Clinical application of a lectin-antibody ELISA to measure fucosylated haptoglobin in sera of patients with pancreatic cancer. Clin Chem and Labo Med. 48(4), 505-512.
• Nakajima K, Kitazume S, Angata T, Fujinawa R, Ohtsubo K, Miyoshi E, Taniguchi N. (2010) Simultaneous determination of nucleotide sugars with ion-pair reversed-phase HPLC. Glycobiology 20(7), 865-871.
• Deguchi T, Tanemura M, Miyoshi E, Nagan H, Machida T, Ohmura Y, Kobayashi S, Marubashi S, Eguchi H, Takeda Y, Ito T, Mori M, Doki Y, Sawa Y. (2010) Increased immunogenicity of tumor-associated antigen, MUC1, engineered to express α-gal epitopes: A novel approach to immunotherapy in pancreatic cancer. Cancer Res. 70(13), 5259-5269.
• Kuwamoto K, Takeda Y, Shirai A, Nakagawa T, Takeishi S, Ihara S, Miyamoto Y, Shinzaki S, Ko JH, Miyoshi E. (2010) Identification of various types of α2-HS glycoprotein in sera of patients with pancreatic cancer: A possible implication for the resistance to protease treatment. Molecular Medicine 3(4), 651-656.
• Yokoe S, Asahi M, Takeda T, Otsu K, Taniguchi N, Miyoshi E,w Suzuki K. (2010) Inhibition of phospholamban phosphorylation by O-GlcNAcylation: Implications for diabetic cardiomyopathy. Glycobiology 20(10), 1217-1226
• Nakagawa T, Takeishi S, Kameyama A, Yagi H, Yoshioka T, Moriwaki K, Masuda T, Matusmoto H, Kato K, Narimatsu H, Miyoshi E. (2010) Glycomic analyses of glycoproteins in bile and serum during rat hepatocarcinogenesis. Journal of Proteome Research 9(10), 4888-4896.
• Misaki R, Morimatsu M, Uemura T, Waguri S, Miyoshi E, Taniguchi N, Matsuda M, Taguchi T. (2010) Palmitoylated ras proteins traffic through recycling endosomes to the plasma membrane during exocytosis. J. Cell Biol 191(1), 23-29.
• Moriwaki K, Narisada M, Imai T, Shinzaki S, Miyoshi E. (2010) The effect of epigenetic regulation of fucosylation on TRAIL-induced apoptosis. Glycoconjugate J. 27(7-9), 649-659.
• Uozumi N, Gao CX, Yoshioka T, Nakano M, Moriwaki K, Nakagawa T, Tanabe M, Miyoshi E. (2010) Identification of a novel type of CA19-9 carrier molecules in human bile and sera of cancer patients: An implication of the involvement in non-secretory exocytosis. Journal of Proteome Research 9(12), 6345-6353.