研究業績集

2023年

• Prohaptoglobin is a possible prognostic biomarker for colorectal cancer Morishita K, Kondo J, Sakon D, Hayashibara A, Tamura I, Shimizu K, Takamatsu S, Murata K, Kamada Y, Miyoshi E. Biochem Biophys Res Commun. 2023 Jun 9;672:72-80. doi: 10.1016/j.bbrc.2023.06.017. Online ahead of print.
• The specific core fucose-binding lectin Pholiota squarrosa lectin (PhoSL) inhibits hepatitis B virus infection in vitro. Ouchida T, Maeda H, Akamatsu Y, Maeda M, Takamatsu S, Kondo J, Misaki R, Kamada Y, Ueda M, Ueda K, Miyoshi E.Sci Rep. 2023 Apr 15;13(1):6175. doi: 10.1038/s41598-023-28572-6.
• Vesicular Integral-Membrane Protein 36 Is Involved in the Selective Secretion of Fucosylated Proteins into Bile Duct-like Structures in HepG2 Cells. Muranaka M, Takamatsu S, Ouchida T, Kanazawa Y, Kondo J, Nakagawa T, Egashira Y, Fukagawa K, Gu J, Okamoto T, Kamada Y, Miyoshi E. Int J Mol Sci. 2023 Apr 11;24(8):7037. doi: 10.3390/ijms24087037.
• Twin research shows glycan changes are more susceptible to environmental factors than their carrier glycoproteins. Asuka T, Kamada Y, Morishita K, Fukuoka T, Takamatsu S, Kondo J, Watanabe M, Sakai N, Hayakawa K, Miyoshi E.; Osaka Twin Research Group. Glycoconj J. 2023 Apr;40(2):191-198. doi: 10.1007/s10719-023-10099-7. Epub 2023 Feb 14.
• Establishment of a novel 70K Mac-2 binding protein antibody through screening of fucosylation-related antibodies. Masuda M, Asuka T, Terao N, Nishino S, Ikeda S, Takamatsu S, Kondo J, Miyoshi E.J Biochem. 2023 Feb 10:mvad015. doi: 10.1093/jb/mvad015. Online ahead of print.
• Hepatocyte differentiation from mouse liver ductal organoids by transducing 4 liver-specific transcription factors. Tomofuji K, *Kondo J, Onuma K, Coppo R, Horie H, Oyama K, Miyoshi E, Fukumitsu K, Ishii T, Hatano E, Inoue M. Hepatol Commun. 2023 Apr 14;7(5):e0134. doi: 10.1097/HC9.0000000000000134. eCollection 2023 May 1. *corresponding author
• EHBP1L1, an apicobasal polarity regulator, is critical for nuclear polarization during enucleation of erythroblasts. Wu J, Moriwaki K, Asuka T, Nakai R, Kanda S, Taniguchi M, Sugiyama T, Yoshimura SI, Kunii M, Nagasawa T, Hosen N, Miyoshi E, Harada A. Blood Adv. 2023 Apr 12:bloodadvances.2022008930. doi: 10.1182/bloodadvances.2022008930. Online ahead of print.
• CKAP4 is a potential exosomal biomarker and therapeutic target for lung cancer. Nagoya A, Sada R, Kimura H, Yamamoto H, Morishita K, Miyoshi E, Morii E, Shintani Y, Kikuchi A. Transl Lung Cancer Res. 2023 Mar 31;12(3):408-426. doi: 10.21037/tlcr-22-571. Epub 2023 Mar 17.
• Diagnostic accuracy of enhanced liver fibrosis test for nonalcoholic steatohepatitis-related fibrosis: Multicenter study. Seko Y, Takahashi H, Toyoda H, Hayashi H, Yamaguchi K, Iwaki M, Yoneda M, Arai T, Shima T, Fujii H, Morishita A, Kawata K, Tomita K, Kawanaka M, Yoshida Y, Ikegami T, Notsumata K, Oeda S, Kamada Y, Sumida Y, Fukushima H, Miyoshi E, Aishima S, Okanoue T, Nakajima A, Itoh Y; Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG-NAFLD). Hepatol Res. 2023 Apr;53(4):312-321. doi: 10.1111/hepr.13871. Epub 2023 Jan 10.
• Core Fucosylation Is Required for the Secretion of and the Enzymatic Activity of SOD3 in Nonsmall-Cell Lung Cancer Cells. Ohkawa Y, Kitano M, Maeda K, Nakano M, Kanto N, Kizuka Y, Seike M, Azuma A, Yamaguchi Y, Ookawara T, Miyoshi E, Taniguchi N. Antioxid Redox Signal. 2023 Mar 6. doi: 10.1089/ars.2022.0010. Online ahead of print.
• Tracking the growth fate of single cells and isolating slow-growing cells in human colorectal cancer organoids. Coppo R, Kondo J, Onuma K, Inoue M. STAR Protoc. 2023 Jun 28;4(3):102395. doi: 10.1016/j.xpro.2023.102395. Online ahead of print.
• Inhibition of the bone morphogenetic protein pathway suppresses tumor growth through downregulation of epidermal growth factor receptor in MEK/ERK-dependent colorectal cancer. Shimizu S, *Kondo J, Onuma K, Coppo R, Ota K, Kamada M, Harada Y, Tanaka Y, Nakazawa MA, Tamada Y, Okuno Y, Kawada K, Obama K, Coffey RJ, Fujiwara Y, Inoue M. Cancer Science 2023 Jun 25. doi: 10.1111/cas.15882. Online ahead of print. *corresponding author
• Ex vivo chemosensitivity assay using primary ovarian cancer organoids for predicting clinical response and screening effective drugs. Ito Y, Kondo J, Masuda M, Matsuzaki S, Onuma K, Kanda M, Watanabe Y, Sakaguchi H, Yoshino K, Ueda Y, Kamiura S, Kimura T, Inoue M. Hum Cell. Hum Cell. 2023 Mar;36(2):752-761. doi: 10.1007/s13577-022-00827-w. Epub 2022 Dec 7.
• Distinct but interchangeable subpopulations of colorectal cancer cells with different growth fates and drug sensitivity. Coppo R, Kondo J, Iida K, Okada M, Onuma K, Tanaka Y, Kamada M, Ohue M, Kawada K, Obama K, Inoue M. iScience 2023 Jan 13;26(2):105962. doi: 10.1016/j.isci.2023.105962. eCollection 2023 Feb 17.

2022年

• Transcription factor SP1 regulates haptoglobin fucosylation via induction of GDP-fucose transporter 1 in the hepatoma cell line HepG2. Kondo J, Sakata N*, Morishita K, Hayashibara A, Sakon D, Takamatsu S, Asakura N, Suzuki T, Miyoshi E. Biochem Biophys Rep. 2022 Oct 25;32:101372. doi: 10.1016/j.bbrep.2022.101372. eCollection 2022 Dec. *co-first author
• Lewis glycosphingolipids as critical determinants of TRAIL sensitivity in cancer cells Fukuoka T, Moriwaki K, Takamatsu S, Kondo J, Tanaka-Okamoto M, Tomioka A, Semba M, Komazawa-Sakon S, Kamada Y, Kaji H, Miyamoto Y, Inoue M, Bessho K, Miyoshi Y, Ozono K, Nakano H, Miyoshi E. Oncogene. Sep;41(38):4385-4396. doi: 10.1038/s41388-022-02434-3. Epub 2022 Aug 15.
• The scaffold-dependent function of RIPK1 in dendritic cells promotes injury-induced colitis. Moriwaki K, Park C, Koyama K, Balaji S, Kita K, Yagi R, Komazawa-Sakon S, Semba M, Asuka T, Nakano H, Kamada Y, Miyoshi E, Chan FKM. Mucosal Immunol. 2022 Jan;15(1):84-95. doi: 10.1038/s41385-021-00446-y.
• Simultaneous analysis of serum α2,3-linked sialylation and core-type fucosylation of prostate-specific antigen for the detection of high-grade prostate cancer. Hatano K, Yoneyama T, Hatakeyama S, Tomiyama E, Tsuchiya M, Nishimoto M, Yoshimura K, Miyoshi E, Uemura H, Ohyama C, Nonomura N, Fujita K. Br J Cancer. 2022 Mar;126(5):764-770. doi: 10.1038/s41416-021-01637-x.
• Enterococcus spp. have higher fitness for survival, in a pH-dependent manner, in pancreatic juice among duodenal bacterial flora. Itoyama S, Noda E, Takamatsu S, Kondo J, Kawaguchi R, Shimosaka M, Fukuoka T, Motooka D, Nakamura S, Tanemura M, Mitsufuji S, Iwagami Y, Akita H, Tobe T, Kamada Y, Eguchi H, Miyoshi E. JGH Open. 2022 Jan 5;6(1):85-90. doi: 10.1002/jgh3.12703.
• TNF receptor-related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF-κB-inducing kinase-mediated hepatocyte transdifferentiation Shiode Y, Kodama T, Shigeno S, Murai K, Tanaka S, Newberg JY, Kondo J, Kobayashi S, Yamada R, Hikita H, Sakamori R, Suemizu H, Tatsumi T, Eguchi H, Jenkins NA, Copeland NG, Takehara T.Hepatology. 2022 Jan 7. doi: 10.1002/hep.32317. Online ahead of print.
• ASURAT: Functional annotation-driven unsupervised clustering of single-cell transcriptomes Iida K, Kondo J, Wibisana JN, Inoue M, Okada M. Bioinformatics. 2022 Aug 4:btac541. doi: 10.1093/bioinformatics/btac541. Online ahead of print.
• Polarity switching of ovarian cancer cell clusters via SRC family kinase is involved in the peritoneal dissemination Kawata M, Kondo J, Onuma K, Ito Y, Yokoi T, Hamanishi J, Mandai M, Kimura T, Inoue M.Cancer Sci. 2022 Jul 18. doi: 10.1111/cas.15493.
• Constitutive Activation of the Tumor Suppressor p53 in Hepatocytes Paradoxically Promotes Non-Cell Autonomous Liver Carcinogenesis Makino Y, Hikita H, Fukumoto K, Sung JH, Sakano Y, Murai K, Sakane S, Kodama T, Sakamori R, Kondo J, Kobayashi S, Tatsumi T, Takehara T. Cancer Res. 2022 Aug 16;82(16):2860-2873. doi: 10.1158/0008-5472.CAN-21-4390.
• Liver ductal organoids reconstruct intrahepatic biliary trees in decellularized liver grafts Tomofuji K, Fukumitsu K, Kondo J, Horie H, Makino K, Wakama S, Ito T, Oshima Y, Ogiso S, Ishii T, Inoue M, Hatano E.Biomaterials. 2022 Jun 1;287:121614. doi: 10.1016/j.biomaterials.2022.121614.
• Ex vivo chemosensitivity assay using primary ovarian cancer organoids for predicting clinical response and screening effective drugs Ito Y, Kondo J, Masuda M, Matsuzaki S, Onuma K, Kanda M, Watanabe Y, Sakaguchi H, Yoshino K, Ueda Y, Kamiura S, Kimura T, Inoue M. Hum Cell. 2023 Mar;36(2):752-761. doi: 10.1007/s13577-022-00827-w. Epub 2022 Dec 7.

2021年

• Challenges in the Application of Glyco-Technology to Hepatitis B Virus Therapy and Diagnosis. Ouchida T, Takamatsu S, Maeda M, Asuka T, Morita C, Kondo J, Ueda K, Miyoshi E. Viruses. 2021 Sep 17;13(9):1860. doi: 10.3390/v13091860.
• Sweet modification and regulation of death receptor signalling pathway. Moriwaki K, Chan FKM, Miyoshi E. J Biochem. 2021 Sep 7;169(6):643-652. doi: 10.1093/jb/mvab034.
• Branched-chain amino acids protect the liver from cirrhotic injury via suppression of activation of lipopolysaccharide-binding protein, toll-like receptor 4, and signal transducer and activator of transcription 3, as well as Enterococcus faecalis translocation. Eguchi A, Iwasa M, Tamai Y, Tempaku M, Takamatsu S, Miyoshi E, Hasegawa H, Kobayashi Y, Takei Y. Nutrition. 2021 Jun;86:111194. doi: 10.1016/j.nut.2021.111194.
• Rifaximin ameliorates intestinal inflammation in cirrhotic patients with hepatic encephalopathy. Tamai Y, Iwasa M, Eguchi A, Shigefuku R, Kamada Y, Miyoshi E, Takei Y. JGH Open. 2021 Jun 23;5(7):827-830. doi: 10.1002/jgh3.12596.
• Identification of fucosylated haptoglobin-producing cells in pancreatic cancer tissue and its molecular mechanism. Ito N, Yamada M, Morishita K, Nojima S, Motooka K, Sakata N, Asuka T, Otsu R, Takamatsu S, Kamada Y, Mori S, Akita H, Eguchi H, Morii E, Miyoshi E. Glycoconj J. 2021 Feb;38(1):45-54. doi: 10.1007/s10719-020-09970-8.
• Detection of fucosylated haptoglobin using the 10-7G antibody as a biomarker for evaluating endoscopic remission in ulcerative colitis. Motooka K, Morishita K, Ito N, Shinzaki S, Tashiro T, Nojima S, Shimizu K, Date M, Sakata N, Yamada M, Takamatsu S, Kamada Y, Iijima H, Mizushima T, Morii E, Takehara T, Miyoshi E. World J Gastroenterol. 2021 Jan 14;27(2):162-175. doi: 10.3748/wjg.v27.i2.162.
• Rab11-mediated post-Golgi transport of the sialyltransferase ST3GAL4 suggests a new mechanism for regulating glycosylation. Kitano M, Kizuka Y, Sobajima T, Nakano M, Nakajima K, Misaki R, Itoyama S, Harada Y, Harada A, Miyoshi E, Taniguchi N. J Biol Chem. 2021 Jan-Jun;296:100354. doi: 10.1016/j.jbc.2021.100354.
• Serum core-type fucosylated prostate-specific antigen index for the detection of high-risk prostate cancer. Fujita K, Hatano K, Tomiyama E, Hayashi Y, Matsushita M, Tsuchiya M, Yoshikawa T, Date M, Miyoshi E, Nonomura N. Int J Cancer. 2021 Jun 15;148(12):3111-3118. doi: 10.1002/ijc.33517.