研究業績集

2020年

• Morishita K, Maki Y, Takamatsu S, Ito N, Koda S, Motooka K, Kamada Y, Kajihara Y,Miyoshi E. (2020) Identification of the epitope of 10-7G glycan antibody to recognize cancer-associated haptoglobin by phenotype. Analytical Biochemistry, 593, 113588
• Kamada Y, Yamamoto A, Fujiyoshi A, Koseki M, Morishita K, Asuka T, Takamatsu S, Sakata Y, Takehara T, Taniguchi N, Miyoshi E (2020) Loss of core fucosylation reduces low-density lipoprotein receptor expression in hepatocytes by inducing PCSK9 production. BBRC 527(3), 682-88.
• Iwaki A, Sobajima T, Moriwaki K, Taniguchi M, Yoshimura S, Kunii M, Kamada Y,Miyoshi E, Harada A. (2020) Loss of Rab6a in the small intestine causes lipid accumulation and epithelial cell death from lactation. FASEB J. in press.
• Iwatani S, Shinzaki S, Amano T, Otake Y, Tani M, Yoshihara T, Tsujii Y, Hayashi Y, Inoue T, Okuzaki D, Mizushima T, Miyoshi E, Iijima H, Takehara T. (2020) Oligosaccharide-dependent anti-inflammatory role of galectin-1 for macrophages in ulcerative colitis. J Gastroenterol Hepatol. 2020 May 18. doi: 10.1111/jgh.15097.
• Kamada Y, Morishita K, Koseki M, Nishida M, Asuka T, Naito Y, Yamada M, Takamatsu S, Sakata Y, Takehara T, Miyoshi E. (2020) Serum Mac-2 Binding Protein Levels Associate with Metabolic Parameters and Predict Liver Fibrosis Progression in Subjects with Fatty Liver Disease: A 7-Year Longitudinal Study. Nutrients 12(6), 1770.
• Zhao T, Masuda T, Miyoshi E, Takai M. (2020) High Dye-Loaded and Thin-Shell Fluorescent Polymeric Nanoparticles for Enhanced FRET Imaging of Protein-Specific Sialylation on the Cell Surface. Anal. Biochem. 92(19), 13271-13280.
• Nagaoka S, Yamada D, Eguchi H, Yokota Y, Iwagami Y, Asaoka T, Noda T, Kawamoto K, Goto K, Kobayashi S, Miyoshi E, Doki Y, Mori M. (2020) The blockade of interleukin 33 released by hepatectomy would be a promising treatment option for cholangiocarcinoma. Cancer Science 112(1), 347-358.

2019年

• Nonomura Y, Sawamura S, Hanazawa K, Nishikaze T, Sekiya S, Higuchi T, Nin F, Uetsuka S, Inohara H, Okuda S,Miyoshi E, Horii A, Takahashi S, Natsuka S, Hibino H. (2019) Characterization of N-glycans in the epithelial-like tissue of rat cochlea. Sci Reports 9(1):1551.
• Fujii M, Ohno Y, Yamada M, Kamada Y, Miyoshi E. (2019) Impact of fatty pancreas and lifestyle on the development of subclinical chronic pancreatitis in healthy people undergoing a medical checkup. Environ Health Prev Med. 24(1):10.
• Sianturi J, Manabe Y, Li HS , Chiu LT, Chang TC, Tokunaga K, Kabayama K, Tanemura T, Takamatsu S, Miyoshi E, Hung SC, Fukase K. (2019) Development of -Gal Antibody Conjugates for Increasing Immune Response by Recruiting Natural Antibodies. Angewandte Chemie 58(14), 4526-4530.
• Fukui H, Hori M, Fukuda Y, Onishi H, Nakamoto A, Ota T, Ogawa K, Ninomiya K, Tatsumi M, Osuga K, Yamada D, Eguchi H, Miyoshi E, Tomiyama N. (2019) Evaluation of fatty pancreas by proton density fat fraction using 3-T magnetic resonance imaging and its association with pancreatic cancer. European Journal of Radiology 118, 25-31.
• Egashira Y, Suganuma M, Kataoka Y, Higa Y, Ide N, Morishita K, Kamada Y, Gu J, Fukagawa K, Miyoshi E. (2019) Establishment and characterization of a fucosylated α-fetoprotein-specific monoclonal antibody: a potential application for clinical research. Sci Rep. 26; 9(1):12359.
• Fujihira H, Masahara-Negishi Y, Akimoto Y, Hirayama H, Lee HC, Story BA, Mueller WF, Jakob P, Clauder-Munster S, Steinmetz LM, Radhakrishnan SK, Kawakami H, Kamada Y, Miyoshi E, Yokomizo T, Suzuki T. (2020) Liver-specific deletion of Ngly1 causes abnormal nuclear morphology and lipid metabolism under food stress. BBA-Molecular Basis of Disease 1866(3) 165599.
• Manabe Y, Marchetti R, Takakura Y, Nagasaki M, Nihei W, Takebe T, Tanaka K, Kabayama K, Chiodo F, Hanashima S, Kamada Y, Miyoshi E, Dulal HP, Yamaguchi Y, Adachi Y, Ohno N, Tanaka H, Silipo A, Fukase K, Molinaro A. (2019) The core fucose on an IgG antibody is an endogenous ligand of Dectin-1. Angewandte Chemie 58 (51), 18697-18702.

2018年

• Nishino K, Koda S, Kataoka N, Takamatsu S, Nakano M, Ikeda S, Kamamatsu Y, Morishita K, Moriwaki K, Eguchi H, Eiko Y, Kikkawa F, Tomita Y, Kamada Y,Miyoshi E. (2018) Establishment of an antibody specific for cancer-associated haptoglobin: A possible implication of clinical investigation. Oncotarget 9(16), 12732-44.
• Sobajima T, Yoshimura S, Maeda T, Miyata H, Miyoshi E, Harada A. (2018) The Rab11-binding protein RELCH/KIAA1468 controls intracellular cholesterol distribution. J. Cell Biology 217(5), 1777-1796.
• Morishita K, Ito N, Koda S, Maeda M, Nakayama K, Yoshida K, Takamatsu S, Yamada M, Eguchi H, Kamada Y, Miyoshi E. (2018) Haptoglobin phenotype is a critical factor in the use of fucosylated haptoglobin for pancreatic cancer diagnosis. Clin. Chim. Acta.487,84-89.
• Maekawa T, Fukaya R, Takamatsu S, Itoyama S, Fukuoka T, Yamada M, Hata T, Nagaoka S, Kawamoto K, Eguchi H, Murata K, Kumada T, Ito T, Tanemura M, Fujimoto K, Tomita Y, Tobe T, Kamada Y, Miyoshi E. (2018) Possible involvement of Enterococcus infection in the pathogenesis of chronic pancreatitis and cancer. Biochem Biophys Res. Commun.506, 962-969.
• Nakayama K, Wakamatsu K, Fujii H, Shinzaki S, Takamatsu S, Kitazume S, Kamada Y, Takehara T, Taniguchi N, Miyoshi E. (2018) Core fucose is essential glycosylation for CD14-dependent Toll-like receptor 4 and Toll-like receptor 2 signaling in macrophages. J Biochem. 165(3):227-237.

2017年

• Manabe Y, Kasahara S, Takakura Y, Yang X, Takamatsu S, Kamada Y, Miyoshi E, Yoshidome D, Fukase K. (2017) Development of α1,6-fucosyltransferase inhibitors through the diversity-oriented syntheses of GDP-fucose mimics using the coupling between alkyne and sulfonyl azide, Bioorganic & Medicinal Chemistry
• Kusama K, Okamoto Y, Saito K, Kasahara T, Murata T, Ueno Y, Kobayashi Y, Kamada Y,Miyoshi E. (2017) Reevaluation of Pholiota squarrosa lectin-reactive haptoglobin as a pancreatic cancer biomarker using an improved ELISA system. Glycoconjugate J, 34(4), 537-54.
• Betesh L, Comunale MA, Wang M, Liang H, Hafner J, Karabudak A, Giama NH, Moser CD, Miyoshi E, Roberts LR, Block TM, Mehta A. (2107) Identification of fucosylated Fetuin-A as a potential biomarker for cholangiocarcinoma. Proteomics Clin Appl. 2017 May 31. doi: 10.1002/prca.201600141
• Shinzaki S, Iijima H, Fujii H, Kamada Y, Naka T, Takehara T, Miyoshi E. A novel pathogenesis of inflammatory bowel disease from the perspective of glyco-immunology. J. Biochem. 2017 Mar 7. doi: 10.1093/jb/mvx010.
• Iijima J, Kobayashi S, Kitazume S, Kizuka Y, Fujinawa R, Korekane H, Shibata T, Saitoh SI, Akashi-Takamura S, Miyake K, Miyoshi E, Taniguchi N. (2017) Core fucose is critical for CD14-dependent Toll-like receptor 4 signaling. Glycobiology 27(11), 1006-1015.
• Hata T, Kawamoto K, Eguchi H, Kamada Y, Takamatsu S, Maekawa T, Nagaoka S, Yamada D, Iwagami Y, Asaoka T, Noda T, Wada H, Gotoh K, Masamune A, Miyoshi E, Mori M, Doki Y. (2017) Fatty Acid-Mediated Stromal Reprogramming of Pancreatic Stellate Cells Induces Inflammation and Fibrosis That Fuels Pancreatic Cancer. Pancreas. 46(10), 1259-1266.
• Furukawa K, Tanemura M, Miyoshi E, Eguchi H, Nagano H, Matsunami K, Nagaoka S, Yamada D, Asaoka T, Noda T, Wada H, Kawamoto K, Goto K, Taniyama K, Mori M, Doki Y. (2017) A practical approach to pancreatic cancer immunotherapy using resected tumor lysate vaccines processed to express α-gal epitopes. PLoS One. 2017 Oct 27;12(10):e0184901. doi: 10.1371/journal.pone.0184901.

2016年

• Takahashi S, Suigiyama T, Shimomura M, Kamada Y, Fujita K, Nonomura N, Miyoshi E, Nakano M. (2016) Site-specific and linkage analyses of fucosylated N-glycans on haptoglobin in sera of patients with various types of cancer: possible implication for the differential diagnosis of cancer. Glycoconjugate J. 33(3):471-82.
• Ueda M, Kamada Y, Takamatsu S, Shimomura M, Maekawa T, Sobajima T, Fujii H, Nakayama K, Nishino K, Yamada M, Kobayashi Y, Kumada T, Ito T, Eguchi H, Nagano H, Miyoshi E.(2016) Specific increase in serum core-fucosylated haptoglobin in patients with chronic pancreatitis. Pancreatology 2016 Jan 21. pii: S1424-3903(16)00009-0. doi: 10.1016/j.pan.2016.01.004.
• Fujii H, Shinzaki S, Iijima H, Wakamatsu K, Iwamoto C, Sobajima T, Kuwahara R, Hiyama S, Hayashi Y, Takamatsu S, Uozumi N, Kamada Y, Tsujii M, Taniguchi N, Takehara T, Miyoshi E. (2016) Core Fucosylation on T cells, Required for Activation of T-cell Receptor Signaling and Induction of Colitis in Mice, is Increased in Patients with Inflammatory Bowel Disease. Gastroenterology 2016 Mar 7. pii: S0016-5085(16)00297-3. doi: 10.1053/j.gastro.2016.03.002.
• Tawara S, Tatsumi T, Iio S, Kobayashi I, Shigekawa M, Hikita H, Sakamori R, Hiramatsu N, Miyoshi E, Takehara T. (2016) Evaluation of Fucosylated Haptoglobin and Mac-2 Binding Protein as Serum Biomarkers to Estimate Liver Fibrosis in Patients with Chronic Hepatitis C. PLoS One. 2016 Mar 22;11(3):e0151828. doi: 10.1371/journal.pone.0151828. eCollection 2016.
• Hasegawa K, Tanaka S, Fujiki F, Morimoto S, Nakano K, Kinoshita H, Okumura A, Fujioka Y, Urakawa R, Nakajima H, Tatsumi N, Nakata J, Takashima S, Nishida S, Tsuboi A, Oka Y, Oji Y, Miyoshi E, Hirata T, Kumanogoh A, Sugiyama H, Hosen N. (2016) Glycosylation Status of CD43 Protein Is Associated with Resistance of Leukemia Cells to CTL-Mediated Cytolysis. PLoS One. 2016 Mar 24;11(3):e0152326. doi: 10.1371/journal.pone.0152326. eCollection 2016.
• Kamada Y, Hashimoto R, Yamamori H, Yasuda Y, Takehara T, Fujita Y, Hashimoto K, Miyoshi E. (2016) Impact of plasma transaminase levels on the peripheral blood glutamate levels and memory functions in healthy subjects. BBA Clin. 5, 101-107.
• Seino J, Fujihira H, Nakakita SI, Masahara-Negishi Y, Miyoshi E, Hirabayashi J, Suzuki T. (2016) Occurrence of free sialyl oligosaccharides related to N-glycans (sialyl FNGs) in animal sera. Glycobiology. 2016 Apr 21.
• Maekawa T, Kamada Y, Ebisutani Y, Ueda M, Hata T, Kawamoto K, Takamatsu S, Mizutani K, Shimomura M, Sobajima T, Fujii H, Nakayama K, Nishino K, Yamada M, Kumada T, Ito T, Eguchi H, Nagano H, Miyoshi E. (2016) Serum Mac-2 binding protein is a novel biomarker for chronic pancreatitis. World J Gastroenterol. 2016 May 7;22(17):4403-10. doi: 10.748/wjg.v22.i17.4403.
• Takamatsu S, Shimomura M, Kamada Y, Maeda H, Sobajima T, Hikita H, Iijima M, Okamoto Y, Misaki R, Fujiyama K, Nakamori S, Kanai Y, Takehara T, Ueda K, Kuroda S, Miyoshi E. (2016) Core fucosylation plays a pivotal role in hepatitis B pseudo virus infection: a possible implication fro HBV glyco-therapy. Glycobiology in press.
• Sawanobori A, Moriwaki K, Takamatsu S, Kamada Y, Miyoshi E. (2016) A glycoproteomic approach to identify novel glycomarkers for cancer stem cells. Proteomics 2016 Mar 7. doi: 10.1002/pmic.201500472 (Review)
• Fujita M, Hayashi T, Matsuzaki K, Nakata W, Kawashima A, Ujike T, Nagahara A, Tsuchiya M, Masuda M, Kobayashi Y, Nojima S, Uemura M, Morii E, Miyoshi E, Nonomura N. (2016) Decreased fucosykated PSA as a urinary marker for high-Gleason prostate cancer. Oncotarget doi: 10.18632/oncotarget.10987.
• Carvalho S, Oliveira T, Bartels MF, Miyoshi E, Pierce M, Taniguchi N, Carneiro F, Seruca R, Reis CA, Strahl S, Pinho SS. (2016) O-mannosylation and N-glycosylation: two coordinated mechanisms regulating the tumour suppressor functions of E-cadherin in cancer. Oncotarget doi: 10.18632/oncotarget.11245.
• Iwata A, Kamada Y, Ebisutani Y, Yamamoto A, Ueda Y, Arai H, Fujii H, Takamatsu S, Maruyama N, Maeda M, Takehara T,Miyoshi E. (2016) Establishment of mouse Mac-2 binding protein enzyme-linked immunosorbent assay and its application for mouse chronic liver disease models. Hepatology Res. 47(9), 902-909
• Kamada Y, Kida S, Hirano KI, Yamaguchi S, Suzuki A, Hashimoto C, Kimura A, Sato M, Fujii H, Sobajima T, Yamamoto A, Ebisutani Y, Takamatsu S, Shinzaki S, Yoshida Y, Yamada M, Nagasaka H, Takehara T,Miyoshi E. (2016) Hepatic aberrant glycosylation by N-acetylglucosaminyltransferase V accelerates HDL assembly. Am J Physiol Gastrointest Liver Physiol. 2016 Nov 1;311(5):G859-G868.

2015年

• Asazawa H, Kamada Y, Takeda Y, Takamatsu S, Shinzaki S, Kim Y, Nezu R, Kuzushita N, Mita E, Kato M, Miyoshi E. (2015) Serum fucosylated haptoglobin in chronic liver diseases as a potential biomarker of hepatocellular carcinoma development. Clin Chem Lab Med. 53(1), 93-98
• Sato M, Kamada Y, Takeda Y, Kida S, Ohara Y, Fujii H, Akita M, Mizutani K, Yoshida Y, Yamada M, Hogaku K, Takehara T, Miyoshi E. (2015) Fetuin A negatively correlates with liver and vascular fibrosis in nonalcoholic fatty liver disease subjects. Liver International 35(3), 925-935.
• Kamada Y, Sato M, Kida S, Akita M, Mizutani K, Fujii H, Sobajima T, Yoshida Y, Shinzaki S, Takamatsu S, Takehara T, Miyoshi E. (2015) N-Acetylglucosaminyltransferase V exacerbates concanavalin A-induced hepatitis in mice. Molecular Medicine Reports 115(5), 3573-84
• Tanida T, Tanemura M, Miysoshi E , Nagano H, Furukawa K, Nonaka Y, Akita H, Hama N, Wada H, Kawamoto K, Kobayashi S, Eguchi H, Mori M, Doki Y. (2015) Pancreatic cancer immunotherapy using a tumor lysate vaccine, engineered to express α-gal epitopes, targets pancreatic cancer stem cells. Int. J. Oncology 46(1), 78-90.
• Honma R, Kinoshita I, Miyoshi E, Tomaru U, Matsuno Y, Shimizu Y, Takeuchi S, Kobayashi Y, Kaga K, Taniguchi N, Akita DH. (2015) Expression of fucosyltransferase 8 is associated with an unfavorable clinical outcome in non-small cell lung cancers. Oncology 88(5), 298-308
• Sobajima T, Yoshimura S, Iwano T, Kunii M, Watanabe M, Atik N, Mushiake S, Morii E, Koyama Y, Miyoshi E, Harada A (2014). Rab11a is required for apical protein localisation in the intestine. Biol Open. 4(1), 86-94
• Wang Y, Fukuda T, Isaji T, Lu J, Gu W, Lee HH, Ohkubo Y, Kamada Y, Taniguchi N, Miyoshi E, Gu J. (2015) Loss of 1,6-fucosyltransferase suppressed liver regeneration: implication of core fucose in the regulation of growth factor receptor-mediated cellular signaling. Scientific Reports 5, 8264 | DOI: 10.1038/srep08264
• Kamada Y, Miyoshi E. (2015) Value of Fetuin-A as a Predictor of Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease. Author's reply. Liver Int. 2015 Mar 24. doi: 10.1111/liv.12833.
• Terao N, Takamatsu S, Minehira T, Sobajina T, Nakayama K, Kamada Y, Miyoshi E. (2015) Fucosylation is common type of glycosylation in pancreatic cancer stem cell-like phenotypes. World J Gastroenterology 21 (13), 3876-3887.
• Kato A, Yutani M, Terao M, Kimura A, Itoi S, Murota H, Miyoshi E, Katayama I. (2015) Oligosaccharide modification by N-acetylglucosaminyltransferase-V in macrophages are involved in pathogenesis of bleomycin-induced scleroderma. Exp Dermatol. 24 (8), 585-590.
• Kamada Y, Ebisutani Y, Kida S, Mizutani K, Akita M, Yamamoto A, Fujii H, Sobajima T, Terao N, Takamatsu S, Yoshida Y, Takehara T, Miyoshi E.(2016) Ectopic expression of N-acetylglucosaminyl transferase V (GnT-V) accelerates hepatic triglyceride synthesis. Hepatology Res. 46 (3), E118-129.
• Matsuda A, Kuno A, Nakagawa T, Ikehara Y, Irimura T, Yamamoto M, Nakanuma Y, Miyoshi E, Nakamori S, Nakanishi H, Viwatthanasittiphong C, Srivatanakul P, Miwa M, Shoda J, Narimatsu H. (2015) Lectin microarray-based sero-biomarker verification targeting aberrant O-linked glycosylation on Mucin 1. Anal. Biochem. 87 (14), 7274-7281.
• Carvalho S, Catarino TA, Dias AM, Kato M, Almeida A, Hessling B, Figueiredo J, G?rtner F, Sanches JM, Ruppert T, Miyoshi E, Pierce M, Carneiro F, Kolarich D, Seruca R, Yamaguchi Y, Taniguchi N, Reis CA, Pinho SS. (2015) Preventing E-cadherin aberrant N-glycosylation at Asn-554 improves its critical function in gastric cancer. Oncogene. 35 (13), 1619-1631.
• Kamada Y, Ono M, Hyogo H, Fujii H, Sumida Y, Mori K, Tanaka S, Yamada M, Akita M, Mizutani K, Fujii H, Yamamoto A, Takamatsu S, Yoshida Y, Ito Y, Kawada N, Chayama K, Saibara T, Takehara T, Miyoshi E.(2015) A novel noninvasive diagnostic method for nonalcoholic steatohepatitis using two glycobiomarkers. Hepatology. 62 (5), 1433-1443
• Shinzaki S, Ishii M, Fujii H, Iijima H, Wakamatsu K, Kawai S, Shiraishi E, Hiyama S, Inoue T, Hayashi Y, Kuwahara R, Takamatsu S, Kamada Y, Morii E, Tsujii M, Takehara T, Miyoshi E. (2015) N-Acetylglucosaminyltransferase V (GnT-V) exacerbates murine colitis with macrophage dysfunction and enhances colitic tumorigenesis. J Gastroenterology 51 (4), 357-69.
• Tanaka-Okamoto M, Yabu, M, Mukai M, Takahashi H, Fujiwara Y, Ohue, M, Kamada Y, Miyoshi E, Miyamoto, Y. (2015) Elevation of CA19-9 related novel marker, Core 1 Sialyl Lewis A, in sera of adenocarcinoma patients verified by a SRM based method. J. Proteome Res. 15 (1), 152-165.
• Miyoshi E, Shinzaki S, Fujii H, Iijima H, Kamada Y, Takehara T. (2015) Role of aberrant IgG glycosylation in the pathogenesis of inflammatory bowel disease. Proteomics Clin Appl. 2015 Oct 2. doi: 10.1002/prca.201500089. (Review)
• Tanemura M, Miyoshi E, Nagano H, Eguchi H, Matsunami K, Taniyama K, Hatanaka N, Akamatsu H, Mori M, Doki Y. (2015) Cancer immunotherapy for pancreatic cancer utilizing α-gal epitope/natural anti-Gal antibody reaction. World J Gastroenterol. Oct 28;21(40), 11396-410. (Review)